Clinical trials: Randomized Controlled Trial (RCT)
Neurotic Disorders
Effectiveness of Online Systematic Brief Psychodynamic Psychotherapy for Neurotic Disorders: Randomized Controlled Trial
Objective: To evaluate the effectiveness of online systematic brief psychodynamic psychotherapy (SBPP) via HIPAA compliant web conferencing on adults with neurotic disorders. Design: Randomized controlled trial. Single blind.
- Trial name
- NCT02257996
- Testing
- Online Systematic Brief Psychodynamic Psychotherapy
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo
Post-traumatic Stress Disorder
Effectiveness of a Brief Intensive Trauma Treatment for Adolescents With (s)PTSD: a Multi-center RCT
The primary objective of this study is to examine the effectiveness of a Brief Intensive Trauma Treatment (BITT) for adolescents with (s)PTSD.
- Trial name
- NCT06143982
- Testing
- Brief Intensive Trauma Treatment
- Where
- 3 sites in Bonaire, Saint Eustatius and Saba , Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hypercholesterolemia
RCT for the Chinese Medicine in Treating Hypercholesterolemia
This is a randomized, double-blind, placebo-controlled clinical trial. Eligible subjects will randomized into a treatment group or placebo group.
- Trial name
- NCT06700408
- Testing
- Dachaihu Decoction combined Erzhiwan with variation
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Low Back Pain, Muscle Weakness
NASM OPT for Gluteal Enhancement in Non-Athletic Women: An RCT
This RCT evaluates a 12-week NASM OPT program targeting gluteal muscle strength, hip aesthetics (shape, lift, circumference), and low back pain in 120 non-athletic women.
- Conditions
- Low Back Pain, Muscle Weakness, Body Image Disturbance
- Trial name
- GlutealEnhan (NCT06977958)
- Testing
- NASM OPT Group, General Exercise Group
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Cystic Fibrosis
Streamlined Treatment of Pulmonary Exacerbations in Pediatrics
The STOP PEDS RCT is a multicenter, parallel, open label randomized controlled trial evaluating the long-term (one year) and short-term safety and efficacy of two antibiotic treatment strategies for the management of outpatient…
- Trial name
- STOP PEDS RCT (NCT06654752)
- Testing
- Immediate Oral Antibiotics, Tailored Treatment: Oral Antibiotics only if Additional Treatment needed
- Where
- 33 sites in United States, Canada
- Volunteers
- 430 people
- Sponsor
- University of Washington, the Collaborative Health Studies Coordinating Center
Behavior Disorders
Teachers and Parents as Partners During Middle School RCT
There are two aims of this study (a) to examine the effect of Teachers and Parents as Partners on student, parent, and teacher outcomes in middle school and (b) identify barriers and facilitators to implementing Teachers and…
- Trial name
- NCT03614026
- Testing
- Teachers and Parents as Partners
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pancreatic Masses
RCT Comparing Accuracy Among Franseen, Forward-bevel Westcott, and Fork-tip EUS-FNB Needle in Diagnosis of Solid Pancreatic Lesions
Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) is a well-established technique for pancreatic tissue acquisition, offering a high diagnostic accuracy ranging from 78% to 95%, along with a favorable safety profile.
- Trial name
- NCT07032974
- Testing
- Franseen, Forward-bevel, Fork-tip
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Mahidol University
Obesity, Pregnancy
A Clinical Care Pathway for Obese Pregnant Women: A Pilot Cluster RCT
Clinics will be randomized to the use of the care pathway for obese pregnant women or standard care. Women who are (1) up to 20 weeks + 6 days gestation into their pregnancy, (2) are carrying one baby (not twins) that is healthy…
- Trial name
- NCT02534051
- Testing
- Clinical Care Pathway
- Where
- Canada
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- McMaster University
HIV Infections
RCT of Russian IDU Peer Network HIV Prevention Intervention - 1
The purpose of this study is to conduct a randomized controlled trial to assess the efficacy of a peer-educator intervention focused on injection drug users and their drug and sexual networks.
- Trial name
- NCT00218673
- Testing
- Peer mentor intervention
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Infertility, Female, IVF
RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle
Although the endometrium has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- NCT04686357
- Testing
- EMMA/ALICE
- Volunteers
- 1,018 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Adjustment Impairment, Accident
SelFIT: Internet-based Treatment for Adjustment Problems After an Accident
In this study, people who suffer from adjustment problems after having experienced an accident will be randomized to one of two study groups.
- Conditions
- Adjustment Impairment, Accident, Adjustment Disorders, Mental Disorder
- Trial name
- SelFIT (NCT03785912)
- Testing
- Internet-based self-help
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University of Bern
Posttraumatic Stress Disorder, Tonic Immobility Response
Development and Evaluation of a Tonic Immobility Focused Psychoeducational Intervention
A randomized controlled trial is planned to evaluate a brief, web-based intervention intended to educate about tonic immobility (TI) within a sample of those who experienced TI in the context of a traumatic event.
- Trial name
- TIP (NCT05113277)
- Testing
- Tonic Immobility Psychoeducation (TIP), Health Education Training (HET)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Florida State University
Gout, Obesity
Orlistat and Weight Management for Uric Acid Control in Obese Gout: A RCT
A total of 120 obese gout patients were included in a 24-week double-blind randomized controlled design. The intervention group received orlistat 120 mg tid + UTL + individualized diet-exercise-behavioral reinforcement weight…
- Trial name
- OWMUAC (NCT07326839)
- Testing
- Orlistat 120 mg, Allopurinol 100 up to 600mg/day, Febuxostat 40mg Tab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- XueMei Guo
PTSD
Safety Study of Riluzole to Treat Post-traumatic Stress Disorder (PTSD)
The purpose of this study is to determine whether Riluzole is effective in the augmentation treatment of post-traumatic stress disorder (PTSD) that is experienced by Active Duty military service members and Operation Enduring…
- Trial name
- NCT02155829
- Testing
- Riluzole
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Uniformed Services University of the Health Sciences
Adolescent Idiopathic Scoliosis
Effectiveness of Acceptance and Commitment Therapy Versus Active Controls in Improving Psychological Functions of Parents and Children With Adolescent Idiopathic Scoliosis: A Randomized Controlled Trial
Systematic reviews revealed that Acceptance and Commitment Therapy (ACT) for parents had medium-to-large effect sizes in improving parental depression/anxiety (d > 0.50), dysfunctional parenting styles (ds = 0.61-0.77), and…
- Trial name
- NCT05919459
- Testing
- 5-week online synchronous ACT intervention, asynchronous online AIS education
- Where
- Hong Kong
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Fibromyalgia Syndrome
Yishen Shujin Decoction for Fibromyalgia Syndrome
This 24-week prospective study (12-week intervention + 12-week follow-up) is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the therapeutic effects of YishenShujin Decoction, a clinically…
- Trial name
- NCT07555691
- Testing
- YishenShujin Decoction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Juan Jiao
Depressive Symptoms, Quality of Life
Different Levels of Guidance in iCBT for Depression (RCT)
The study examines the effectiveness of a internet-based self-help-program called Selfapy for individuals who are experiencing mental stress.
- Conditions
- Depressive Symptoms, Quality of Life, Self Esteem
- Trial name
- NCT04551794
- Testing
- Selfapy with therapeutic guidance, Selfapy with additional peer support
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cognitive Decline, Cognitive Impairment, Mild
Effects of Multimodal Training of Combined Cognitive and/or Physical Training on Cognition and Fitness of Older Adults
The elderly population worldwide is expected to increase exponentially. There will be a higher percentage of older adults suffering cognitive decline in the coming decades.
- Trial name
- MTCCP (NCT04727450)
- Testing
- Cognitive training, physical training, Combination of cognitive and physical training (CCPT)-BIGMAP
- Where
- Hong Kong
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Radiotherapy Side Effect, Locoregional Recurrence
RCT Comparing 2 Radiotherapy HypoFractionation Schedules In Breast Cancer Patients
This is a prospective randomized Phase III trial to assess efficiency of two post mastectomy hypofractionation schedules (40 Gy /15 fx / 3 weeks, 5 days per week VS 28.5 Gy delivered in 5 once-weekly fractions of 5.7 Gy each…
- Trial name
- Breastcancer (NCT04550910)
- Testing
- Hypofractionation Schedules for Breast Cancer patients after mastecomy
- Where
- Egypt
- Volunteers
- 166 people
- Sponsor
- National Cancer Institute, Egypt
Suicide Attempt
RCT of Post-Suicide Attempt Case Management (ACTION-J)
This study will determine the effectiveness of continuous follow-up care by case manager in preventing further suicide attempts
- Trial name
- ACTION-J (NCT00736918)
- Testing
- Case management, Enhanced usual care
- Where
- 18 sites in Japan
- Volunteers
- 914 people
- Sponsor
- Japan Foundation for Neuroscience and Mental Health