Clinical trials: Randomized Controlled Trial (RCT)
Hypertension, Overweight or Obesity
Education to Decrease in Sodium Intake Evaluated With 24 Hour Urinary Sodium Excretion (RCT)
WHO identifies as an important risk factor and potentially modifiable to high sodium intake (>2g/day 5g salt/day). Also, an insufficient consumption of potassium ( 3.5 g/day).Therefore, the results of this research could be the…
- Conditions
- Hypertension, Overweight or Obesity, Diabetes Mellitus, Type 2
- Trial name
- RCT (NCT04894344)
- Testing
- Education group
- Where
- Mexico
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Colon Cancer Screening
A Study of Using Social Networks to Encourage Three Peers to Complete Screening for Colorectal Cancer
The Black community has higher rates of colorectal cancer and lower rates of colorectal cancer screenings than whites. Getting screened through FIT testing may help catch colorectal cancer earlier, when it is easier to treat.
- Trial name
- NCT05793593
- Testing
- FITx3 intervention and CRC education, Colorectal Cancer (CRC) education alone
- Where
- 7 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Alveolar Bone Atrophy
Efficacy in Alveolar Bone Regeneration With Autologous MSCs and Biomaterial in Comparison to Autologous Bone Grafting
A randomized controlled clinical multi center trial to assess the efficacy of a combination of autologous mesenchymal stem cells and biomaterial in jaw bone regeneration prior to dental implant placement in comparison to standard…
- Trial name
- Maxibone (NCT04297813)
- Testing
- Advanced medicinal Therapy (MSC combined with biomaterial), Autologous bone graft
- Where
- 6 sites in Denmark, France and 2 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Chronic Pain, Mild Cognitive Impairment
Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT
The goal of this clinical trial is to pilot a randomized controlled trial comparing an adaptation of mindfulness-based cognitive therapy to the health enhancement program for chronic pain and early cognitive decline.
- Trial name
- NCT07785648
- Testing
- Feeling of Being, Health Enhancement Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hyperemesis Gravidarum, Nausea Gravidarum
Validating the Effect og Ondansetron and Mirtazapine in Treating Hyperemesis Gravidarum
The aim is to investigate the efficacy of mirtazapine and ondansetron as treatment for hyperemesis gravidarum(HG). The setup is a double-blind multicenter trial where patients suffering from HG will be randomized to treatment…
- Conditions
- Hyperemesis Gravidarum, Nausea Gravidarum, Vomiting of Pregnancy
- Trial name
- VOMIT (NCT03785691)
- Testing
- Mirtazapine, Ondansetron
- Where
- 7 sites in Denmark
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Anxiety, Psychological Flexibility
Comparative Effects of Four Brief Breathwork and Mindfulness Interventions on Anxiety and Psychological Flexibility: A 4-Arm RCT
This four-arm, single-blind randomized controlled trial examines the effects of four brief daily 5-minute practices over 28 days on psychological flexibility and physiological variables in Spanish-speaking adults.
- Conditions
- Anxiety, Psychological Flexibility, Stress
- Trial name
- BREATH-4 (NCT07621042)
- Testing
- Box Breathing, Cyclic Sighing, Mindfulness AH Exhalation
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Valencian International University (VIU)
Sense of Coherence
Effect of Music Breathing for Promoting Sense of Coherence in Young People: RCT
The goal of this experimental study is to test the effects of Music Breathing (MB) in promoting a sense of coherence among young people.
- Trial name
- NCT05655234
- Testing
- Music Breathing, Control condition
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Tung Wah College
Pain, Postoperative, Total Knee Arthroplasty
Duloxetine RCT on Postop TKA Outcomes
The aim of this study is to determine if duloxetine is associated with differences in post-operative pain, patient-reported outcome measures, and opioid consumption in patients undergoing primary total knee arthroplasty compared…
- Trial name
- NCT05086393
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Stimulant Use Disorder
Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment
This project will evaluate the ability of Mirtazapine (MZP), a pharmacologically unique medication with a growing body of evidence to support its efficacy and safety for the treatment of methamphetamine (MA) use among medication…
- Trial name
- MIRROM (NCT06323837)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington State University
Yoga-Based Recovery Course, Control
ED Recovery Course Online RCT
The purpose of this study is to examine whether the Eat Breathe Thrive (EBT) Yoga for Eating Disorder Recovery online course is effective in supporting eating disorder recovery.
- Trial name
- NCT04557566
- Testing
- EBT yoga-based eating disorder course
- Where
- United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Non-Small Cell Lung Carcinoma, Compliance Behavior
Patient Navigation for Lung Cancer Screening in an Urban Safety-Net System
The study proposes to evaluate a patient navigation intervention among a sample of 446 individuals referred for CT-based lung cancer screening in an urban safety-net setting.
- Conditions
- Non-Small Cell Lung Carcinoma, Compliance Behavior, Prevention Harmful Effects
- Trial name
- NCT02758054
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Periodontal Pocket
Non-surgical Step 3 Periodontal Treatment With/Without Adjunctive Protocol - Pilot RCT.
Study conducted in patients recruited at private praxis setting after completed step 2 periodontal therapy. Residual pockets ≥4mm with positive bleeding or such >5mm randomly allocated to either conventional subgingival…
- Trial name
- NCT06438354
- Testing
- subgingival instrumentation plus Perisolv / hyaDent BG, subgingival instrumentation
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Spectrum of Altitude-associated Neurologic Forms of Altitude
NSAID RCT for Prevention of Altitude Sickness
The proposed study is a prospective, randomized, double-blind, placebo-controlled clinical trial evaluating ibuprofen and placebo for the prevention of neurological forms of altitude illness [including high altitude headache…
- Trial name
- NCT01606527
- Testing
- Ibuprofen 600mg orally three times daily
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Naval Health Research Center
Caregiver Burden, Self Efficacy
An Online Ecoaching RCT Intervention for Carers: Enhancing Wellbeing and Resilience Through Self-Help Strategies
The goal of this three-armed, double-blind randomized controlled trial (RCT) is to compare the effectiveness of an online self-help eCoaching intervention designed for caregivers.
- Conditions
- Caregiver Burden, Self Efficacy, Quality of Life, Anxiety Depression
- Trial name
- NCT06604481
- Testing
- eCoaching for Caregivers of Older Adults, eCoaching (need specific) for Caregivers of Older Adults, Control Intervention for Caregivers of Older Adults
- Where
- Hong Kong
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Vaccine Hesitancy, Vaccine Acceptance
Development and Evaluation of a Digital Educational Intervention to Improve Vaccine Confidence and Communication Among Registered Nurses: Protocol for a Randomized Controlled Trial (VaxNurse-RCT).
Nurses play an important role in providing vaccine information and supporting informed vaccination decisions. This study will evaluate a digital educational intervention designed for registered nurses in Quebec.
- Trial name
- VaxNurse-RCT (NCT07859579)
- Testing
- Digital educational intervention
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Muscular Sarcoidosis
Effect of Schisandra Chinensis Extract on Musculoskeletal Biomakers in Relatively Sarcopenic Adults: a RCT
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the SCE on muscle strength, muscle mass, and muscle function in healthy adults for 12 weeks.
- Trial name
- NCT03402308
- Testing
- Schisandra chinensis extract
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Breast Feeding
RCT of Evening Primrose Oil for the Treatment of Breastfeeding Pain
Breastfeeding related mastalgia is a common post-partum complaint. We propose a double-blind, randomized, placebo-controlled trial that investigates the use of Evening Primrose Oil in the treatment of breastfeeding related…
- Trial name
- NCT03876899
- Testing
- Evening Primrose Oil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Substance Addiction
Maternal Acupuncture for Substance Abuse
To determine the efficacy of daily maternal acupuncture treatments in reducing the frequency and severity of neonatal abstinence syndrome among infants born to substance-using women..
- Trial name
- NCT00225316
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Effectiveness of Microscope During Apical Surgery in Endodontic Treated Teeth.
RCT: Effectiveness of a Microscope During Dental Root Apical Surgery
An endodontic treatment is the standard therapy for teeth with periapical periodontitis. The overall success rate for this treatment is high; 97% of the treated teeth are retained in the oral cavity after 8 years (Salehrabi \&…
- Trial name
- NCT01759069
- Testing
- Surgical treatment with microscope
- Where
- Netherlands
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)