Clinical trials: Randomized Controlled Study
Lymphoma, High-Grade
R-BL-M-04 Versus R-(DA)-EPOCH and Autologous Stem Cells Transplantation in Patients With High-Grade B-cell Lymphoma Double-hit (HGBL DH) and High-Grade B-cell Lymphoma Not Otherwise Specified (HGBL NOS)
Purpose: to evaluate an efficacy of chemotherapy regimens R-DA-EPOCH-21 and R-BL-04 with and without autologous hematopoietic stem cells transplantation (auto-SCT) in newly diagnosed patients with High-Grade B-cell Lymphoma…
- Trial name
- NCT03479918
- Testing
- R-DA-EPOCH-21, R-BL-M-04, R-DA-EPOCH-21 + auto-SCT
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Elena N.Parovichnikova
COPD
Therapeutic Effect of PBF-680 in Patients With COPD
The purpose of the study is to investigate the effect of PBF-680 on the chronic inflammation and the lung function of patients with COPD on top of the standard medication.
- Trial name
- Respire (NCT05262218)
- Testing
- PBF-680 10mg
- Where
- 7 sites in Spain
- Volunteers
- 174 people
- Sponsor
- Palobiofarma SL
Head and Neck Cancer
Internet-based Support for Informal Caregivers of Patients With Head and Neck Cancer - Carer eSupport
The aim of this randomized controlled trial is to investigate the effects of internet-based support (Carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer.
- Trial name
- NCT06307418
- Testing
- Carer eSupport
- Where
- 4 sites in Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Maternal Distress, Prenatal Stress
Laughter Yoga's Impact on Traumatic Childbirth Preparation
This study will be conducted as a single-center, parallel-group, randomized controlled intervention trial to determine the effects of birth preparation training supported by laughter yoga on the perception of traumatic birth…
- Conditions
- Maternal Distress, Prenatal Stress, Pregnancy Related
- Trial name
- NCT06663397
- Testing
- Laughter Yoga, Standard Childbirth Preparation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ankara University
Non-small Cell Lung Cancer (NSCLC)
A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with…
- Trial name
- SKYSCRAPER-06 (NCT04619797)
- Testing
- Tiragolumab, Atezolizumab, Pemetrexed
- Where
- 127 sites in United States, Belgium and 19 more
- Volunteers
- 542 people
- Sponsor
- Hoffmann-La Roche
Osteoarthritis
A Study for Moderate Osteoarthritis of the Knee
This is a study to determine whether Flexsure is Safe, Tolerable and Effective in relieving symptoms of Moderate Osteoarthritis of the Knee.
- Trial name
- Flexsure (NCT01478997)
- Testing
- Flexsure Capsules
- Where
- 2 sites in India
- Volunteers
- 76 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Acne Vulgaris
Double-blind Placebo-controlled Trial of Generic Clindamycin/Benzoyl Peroxide Gel Versus Onexton Gel in Acne Vulgaris
Actavis has developed a generic formulation of clindamycin 1.2% and benzoyl peroxide 3.75% gel. This study is designed to evaluate the safety and efficacy of this formulation in subjects with Acne Vulgaris
- Trial name
- NCT02616614
- Testing
- Onexton, Clindamycin/benzoyl peroxide gel
- Where
- 17 sites in United States
- Volunteers
- 862 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Pain, Postoperative
Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty
Lipoabdominoplasty and liposuction are one of the most common plastic surgeries. The management of postoperative pain is complex.
- Trial name
- KEMPLA (NCT02450214)
- Testing
- Saline, Ketamine, Ketamine + magnesium
- Where
- Chile
- Volunteers
- 63 people
- Sponsor
- University of Chile
Pulmonary Disease, Chronic Obstructive, COPD
Indacaterol Delivered Via a Single Dose Dry Powder Inhaler (SDDPI) in Chronic Obstructive Pulmonary Disease (COPD)
The study is designed to obtain safety and efficacy data on three dose levels of indacaterol when delivered via an SDDPI in patients with COPD.
- Conditions
- Pulmonary Disease, Chronic Obstructive, COPD, Lung Diseases, Obstructive
- Trial name
- NCT00396604
- Testing
- indacaterol maleate
- Where
- Belgium
- Volunteers
- 51 people
- Sponsor
- Novartis
Pancreatic Cancer
Gemcitabine and Capecitabine With or Without T-ChOS as Adjuvant Therapy for Patients With Resected Pancreatic Cancer
This is a single center, randomized, double-blind, placebo-controlled phase II trial that will compare the efficacy of T-ChOS in combination with gemcitabine to gemcitabine alone as adjuvant treatment for 6 months in patients…
- Trial name
- CHIPAC (NCT02767752)
- Testing
- T-ChOS, Gemcitabine, Capecitabine
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Herlev Hospital
Uterine Fibroids
Study of Proellex in Pre-menopausal Women With Symptomatic Uterine Fibroids
Two (2) dose levels of Proellex or placebo will be administered once-daily for up to 91 days. Following screening and a pre-treatment endometrial biopsy, subjects will be followed monthly for the three month treatment phase.
- Trial name
- NCT00882258
- Testing
- 12.5 mg Proellex, 25 mg Proellex
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- Repros Therapeutics Inc.
Total Knee Arthroplasty
IPACK Block in Total Knee Arthroplasty
100 patients ASA I-III, undergoing total knee arthroplasty under spinal anesthesia, will be randomly assigned into one of two groups, namely group A (n=50), where an adductor canal block and an IPACK block will be performed…
- Trial name
- NCT03692858
- Testing
- Adductor Canal Block plus IPACK Block, Adductor Canal Block
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Asklepieion Voulas General Hospital
Obesity
A Study to Assess Safety, Tolerability, and Pharmacokinetics of MEDI0382 in Non-diabetic Obese Participants
This is a Phase 1, randomized, blinded, placebo-controlled study in up to approximately 51 non-diabetic obese participants with a body mass index (BMI) ≥ 35 kg/m^2.
- Trial name
- NCT03625778
- Testing
- MEDI0382
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- MedImmune LLC
Coronavirus Infections
The Efficacy of Lopinavir Plus Ritonavir and Arbidol Against Novel Coronavirus Infection
The study explores the efficacy of lopinavir plus ritonavir and arbidol in treating with novel coronavirus infection. As a result this study would provide evidence for the clinical usage of these drugs in the future .
- Trial name
- ELACOI (NCT04252885)
- Testing
- Lopinavir and Ritonavir Tablets, Arbidol
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Guangzhou 8th People's Hospital
COVID-19
The Phase 2 Study to Evaluate the Safety and Efficacy of Clevudine in Patients With Moderate COVID-19
The purpose of this clinical trial is to assess the safety and efficacy of Clevudine 120 mg versus placebo once daily administration with standard of care therapy for 14 days (maximum up to 21 days) in patients with moderate…
- Trial name
- NCT04347915
- Testing
- Clevudine
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Bukwang Pharmaceutical
Allergic Rhinitis
Efficacy and Safety of Xinyi Powder in Patients With Allergic Rhinitis and the Lung Deficiency and Cold Syndrome
By observing the improvement of Xinyi Powder powder and simulated agent on the symptoms, symptom and sign scores, nasal symptom VAS scores, and quality of life of patients with allergic rhinitis due to lung deficiency and cold…
- Trial name
- NCT07899515
- Testing
- Xinyi Powder
- Where
- 2 sites in China
- Volunteers
- 228 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Glaucoma, Ocular Hypertension
Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension
This purpose of this study is to access the efficacy, tolerability and safety of RKI983 (0.05% and 0.10%) ophthalmic solution bid versus once daily latanoprost 0.005%, in patients with POAG or ocular hypertension.
- Trial name
- NCT00846989
- Testing
- RKI983A, Latanoprost
- Where
- 29 sites in United States
- Volunteers
- 276 people
- Sponsor
- Novartis Pharmaceuticals
PCOS (Polycystic Ovary Syndrome)
Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS
The goal of this clinical trial (prospective randomized controlled trial) is to compare whether myo-inositol alone or in combination with metformin can improve conception rates, treatment compliance, and side-effect profiles in…
- Trial name
- NCT07323589
- Testing
- Myoinositol, Metformin 1500 mg daily
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- PAEC general hospital
Patient Comfort, Anxiety
Family Support Weaning from Mechanical Ventilation in Cardiovascular Surgery
Mechanical ventilation support is used to ensure airway clarity in patients after surgery.If patients are not informed about mechanical ventilation treatment in the pre -operation period, panic, anxiety and comfort may be…
- Conditions
- Patient Comfort, Anxiety, Patient Satisfaction
- Trial name
- NCT05820789
- Testing
- Family support
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kastamonu University
Small Cell Lung Cancer
Phase 3 Clinical Study of Chiauranib Capsule in Patients With Small-cell Lung Cancer
Chiauranib , which simultaneously targets against VEGFR/Aurora B/CSF-1R, several key kinases involved in tumor angiogenesis, tumor cell mitosis, and chronic inflammatory microenvironment.
- Trial name
- NCT04830813
- Testing
- Chiauranib
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Chipscreen Biosciences, Ltd.