Clinical trials: Randomized Clinical Trial
Child, Anesthesia Morbidity
A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
Sevoflurane with its rapid induction and emergence, hemodynamic stability, and nonirritating airway properties, has acquired widespread acceptance in children.
- Conditions
- Child, Anesthesia Morbidity, Delirium on Emergence
- Trial name
- NCT01680471
- Testing
- Midazolam 0.03mg/kg, Midazolam 0.05mg/kg
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Korea University Anam Hospital
Functional Dyspepsia
Transcutaneous Auricular Vagus Nerve Stimulation Treatment on Functional Dyspepsia
Objective: To observe the effect of the treatment of transcutaneous auricular vagus nerve stimulation (taVNS) for the functional dyspepsia (FD). Methods: We accrued 94 patients at Beijing TongRen Hospital.
- Trial name
- NCT04706871
- Testing
- taVNS, tnVNS
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Tongren Hospital
Rabies
Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.
This is an exploratory trial to evaluate the effect of antimalarial drugs on the immune response generated by rabies vaccine when administered for post-exposure prophylaxis.
- Trial name
- MALRAB (NCT02564471)
- Testing
- Chloroquine, Atovaquone and Proguanil, Doxycycline
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Posttraumatic Stress Symptoms
The Effect of Guided Narrative Technique on Child Post-traumatic Stress Symptoms Related to Teachers' Improper Criticism
Teachers' improper criticism may lead to posttraumatic stress symptoms (PTSS) in children. This cluster randomized controlled trial examined the effect of guided narrative technique (GNT) on child PTSS caused by teachers'…
- Trial name
- NCT05416671
- Testing
- guided narrative technique-writing
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Peking University
Pain, Postoperative, Rebound Pain
Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery
Shoulder surgery often causes severe pain after the operation. To control this pain, doctors commonly perform a nerve block (interscalene brachial plexus block), which numbs the shoulder area.
- Conditions
- Pain, Postoperative, Rebound Pain, Shoulder Injuries, Rotator Cuff Injuries
- Trial name
- NCT07699744
- Testing
- Dexamethasone (IV), Single-shot interscalene brachial plexus block, Continuous interscalene brachial plexus block
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Seoul National University Hospital
Hypertrophic Cardiomyopathy
Mitral Valve Management During Septal Myectomy
Objective of the study: to evaluate whether alfieri technique improves clinical and hemodynamic results compared to transaortic mitral valve secondary cord cutting in patients scheduled to septal myectomy for severely symptomatic…
- Trial name
- MVMSM (NCT03906734)
- Testing
- Septal myectomy, alfieri stich, Subvalvular intervention
- Where
- Russia
- Volunteers
- 48 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Prolonged Disorders of Consciousness
Speaking Valve Trial vs. Capping Trial for Tracheostomy Decannulation in Prolonged Disorders of Consciousness
To assess whether the speaking valve trial, when employed as an indicator for extubation during the removal of tracheostomy tubes in patients with chronic consciousness disorder, provides superior benefits and heightened…
- Trial name
- SPEAK-CAP (NCT07173634)
- Testing
- Speaking Valve Trial, Capping Trial
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Hongying Jiang, MD
Alarm Fatigue in Intensive Care Unit Nurses, Psychological Well-Being in Intensive Care Unit Nurses
Effects of Relaxation, Mindfulness, and Breathing Therapy on Alarm Fatigue and Psychological Well-being in Intensive Care Nurses
The goal of this clinical trial is to compare the effects of the Benson Relaxation Technique, mindfulness-based stress reduction meditation, and breathing therapy on reducing alarm fatigue and improving psychological well-being…
- Trial name
- NCT07124364
- Testing
- Benson Relaxation Technique, Mindfulness-Based Stress Reduction Meditation, Breathing Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Hacer Eroglu
Dental Pain, Anesthesia, Local
Self-Reported Pain in Children Submitted to Single Infiltration of Articaine During Primary Molar Extraction
The aim of this study is to analyze the effectiveness of articaine in controlling self-reported pain compared with conventional lidocaine anesthesia in children requiring extraction of deciduous maxillary molars.
- Trial name
- NCT05443009
- Testing
- Lidocaine, Articaine
- Where
- 4 sites in Brazil
- Volunteers
- 76 people
- Sponsor
- Universidade Federal de Santa Catarina
Type 2 Diabetes Mellitus
Study of Multiple Doses of Saxagliptin (BMS-477118)
To evaluate the positive efficacy trend among doses of saxagliptin (BMS-477118) in subjects with Type 2 diabetes mellitus by assessing the change from baseline in HbA1c following 12 weeks of double-blind treatment.
- Trial name
- NCT00950599
- Testing
- Saxagliptin
- Volunteers
- 423 people
- Sponsor
- AstraZeneca
Intensive Care Unit, Critical Care
Effects of Nonpharmacological Interventions in Sleep Quality, Anxiety, and Delirium for Patients of Adult Intensive Care Units
This study will investigate the effect of nonpharmacological intervention in sleep quality, anxiety and delirium among adult ICU patients.
- Conditions
- Intensive Care Unit, Critical Care, Sleep Quality, Anxiety
- Trial name
- Sleep (NCT06774599)
- Testing
- music combined with lavender essential oil group
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital
Menopause, Hot Flashes
Randomized Evaluation of Natural Extract for Menopausal Wellness (RENEW)
This study will evaluate whether an 8-week course of a standardized herbal extract containing Shatavari and natural bio-enhancer ingredients can reduce menopausal symptoms in post-menopausal women.
- Trial name
- RENEW (NCT07834463)
- Testing
- Shatavari (Asparagus racemosus) Extract
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- India Glycols Ltd
Hernia, Inguinal, Laparoscopic Surgery
Progrip Versus ProFlor: Two Fixation Free Devices for Laparoscopic Inguinal Hernia Repair
there are currently two methods for fixation free laparoscopic inguinal hernia repair specifically based on the intrinsic properties of the device used.
- Trial name
- ProPro (NCT06556498)
- Testing
- Proflor group, Progrip group
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Palermo
Staphylococcal Infections
A Trial to Evaluate the Loading Dose Required to Achieve Therapeutic Serum Teicoplanin Concentration Timely
The purpose of this study is to determine whether the standard dosage of teicoplanin is adequate to produce timely the trough level > 10 mg/L, which is considered to be effective in the treatment of methicillin-resistant…
- Trial name
- NCT00368498
- Testing
- teicoplanin
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Ridge Augmentation
Autogenous Bone Ring Versus Split Bone Block for Management of Posterior Atrophic Mandible
Teeth loss in the posterior mandible initiates residual ridge resorption especially in vertical direction, this causes difficulty in implant placement so ridge augmentation must be done either simultaneous with implant placement…
- Trial name
- NCT07140887
- Testing
- Bone Ring, Split Bone block
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Alexandria University
Blood Pressure
A Randomized, Placebo-Controlled, Double-Blind, Double Dummy Trial To Determine The Relative Effect Of Pm101 Versus Placebo And Amiodarone IV On Blood Pressure In Subjects With Stable Congestive Heart Failure
The primary objective of this trial is to compare the relative hemodynamic effect of a novel intravenous formulation of amiodarone (PM101), administered as an immediate IV bolus push, with placebo and with the currentlyl…
- Trial name
- NCT00739193
- Testing
- amiodarone
- Sponsor
- Prism Pharmaceuticals
Hypertrophic Obstructive Cardiomyopathy
Mobilization of Endothelial Progenitor Cells and Aspirin
Aspirin at doses used during acute myocardial infarction may inhibit the mobilization of endothelial progenitor cells (EPCs).
- Trial name
- TROPHIC 3 (NCT02674958)
- Testing
- Aspirin
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Symptomatic Irreversible Pulpitis and Post Operative Pain
Laser-Assisted vs Conventional Total Pulpotomy in Symptomatic Irreversible Pulpitis
his randomized controlled clinical trial will compare laser-assisted total pulpotomy with conventional total pulpotomy in permanent molar teeth diagnosed with symptomatic irreversible pulpitis.
- Trial name
- LASERPULP (NCT07850258)
- Testing
- Conventional Total Pulpotomy, Laser-Assisted Total Pulpotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- meliksahgunduz
Behavioral and Psychiatric Symptoms of Dementia
Use of a Diary to Assess and Monitor Behavioral and Psychological Symptoms of Dementia ( BPSDiary )
The goal of this randomized clinical trial is to compare the efficacy of the use of a diary to record behavioral and psychological symptoms of dementia (BPSD) in persons with dementia.
- Trial name
- BPSDiary (NCT05977855)
- Testing
- BPSDiary
- Where
- 9 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Lung Biopsy
Novel Use of Extrapleural Autologous Blood Injection in CT-guided Percutaneous Lung Biopsy
The purpose of this study is to evaluate the rate of iatrogenic pneumothorax and the need for intervention with extrapleural autologous blood injection (EPABI) along with intraparenchymal autologous blood patch injection (IABPI)…
- Trial name
- NCT04415255
- Testing
- EABPI plus IABPI, IABPI-alone
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Namik Kemal University