Clinical trials: Randomized Clinical Trial
Healthy
Study To Evaluate the Safety, Tolerability, and Pharmacokinetics After Subcutaneous Administration of C1K in Healthy Subjects
A dose-block randomized, double-blind, placebo-controlled, single and multiple ascending dose, first-in-human, phase 1 first in human clinical trial to evaluate the safety, tolerability, and pharmacokinetics after subcutaneous…
- Trial name
- NCT05701644
- Testing
- C1K 150mg, C1K 300mg, C1K 600mg
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ensol Bioscience
Caries
Effect of CPP-ACP With/Without Fl on White Spot Lesion,Salivary pH and fl Release in High Caries Risk Patients
Effect of CPP-ACP pastes with/without Fluoride on White spot lesion progression, salivary pH and fluoride release in high caries risk Patients, over 3 month period using VistaCam, Digital pH meter and Selective ion electrode.
- Trial name
- NCT03656432
- Testing
- CPP-ACP paste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Labor Induction, Cervical Ripening
Trial of Foley Catheter With and Without Extra-Amniotic Saline Infusion for Labor Induction
The purpose of this study is to compare the efficacy of a transcervical Foley catheter with and without extra-amniotic saline infusion (EASI) for priming the cervix for labor.
- Trial name
- FOLEYEASI (NCT00442663)
- Testing
- Transcervical Foley Catheter, Transcervical Foley Catheter with an EASI
- Where
- 4 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Covid19
An Effectiveness Study of the Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine
This is a stepped-wedge cluster randomized trial to assess effectiveness of Sinovac's Adsorbed COVID-19 (Inactivated) vaccine. Residents in the urban area of a municipality are eligible to participate.
- Trial name
- ProjetoS (NCT04747821)
- Testing
- Adsorbed COVID-19 (Inactivated) Vaccine
- Where
- Brazil
- Volunteers
- 27,711 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Extraction of Third Molar Teeth
Perioperative Acupuncture for Impacted Mandibular Third Molar Extractions
This is a double-blinded, randomized, controlled study on the effect of perioperative acupuncture on pain after third molar extraction.
- Trial name
- NCT02498184
- Testing
- acupuncture
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Class I Dental Caries
CLINICAL COMPARISON OF DIFFERENT GLASS IONOMER-BASED RESTORATIVES AND A BULK-FILL RESIN COMPOSITE IN CLASS I CAVITIES: A 48-MONTH RANDOMIZED SPLIT-MOUTH CONTROLLED TRIAL
The aim of this study is to compare the clinical performances of high-viscosity glass ionomer (GI), glass carbomer (GC), zirconia-reinforced GI (ZIR), and bulk-fill (BF) composite resin restorations.For this purpose, two…
- Trial name
- NCT05559333
- Testing
- class I restoration placement
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Stress, Anxiety
Perceived Stress and Anxiety Levels of Nurses
This study was conducted to determine the effect of web-based progressive relaxation exercises applied to nurses working in a pandemic hospital on perceived stress and anxiety.
- Trial name
- stress (NCT05087433)
- Testing
- Progressive Relaxation Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ayşe Aydınlı
Primigravida Women, Music Therapy
Effect of Music and Warm Foot Bath Therapy on Pregnancy-Related Anxiety, Blood Pressure and Quality of Life
Study Title: The Effects of Music Therapy and Warm Foot Bath on Pregnancy-Related Stress, Blood Pressure, and Quality of Life in Low-Risk Primigravida Women Brief Summary: This randomized controlled trial investigates the impact…
- Conditions
- Primigravida Women, Music Therapy, Blood Pressure Monitoring, Quality of Life
- Trial name
- NCT07064733
- Testing
- Music Therapy, warm water foot bath therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Falls
Action Seniors! Exercise to Prevent Falls
This study will be a randomized controlled trial to determine the efficacy of the Otago Exercise Program (OEP) on falls among seniors with a history of falls.
- Trial name
- NCT01029171
- Testing
- Home-based balance and strength retraining exercise program., control; usual care
- Where
- Canada
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Hypertension
Community Hypertension Assessment Trial (CHAT)
The Community Hypertension Assessment Trial (CHAT) is an investigation of the effect of community pharmacy based blood pressure (BP) monitoring sessions led by peer health educators, with feedback to family physicians, on the…
- Trial name
- NCT00217334
- Testing
- Volunteer-led pharmacy sessions with feedback to physicians
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Bronchogenic Carcinoma
Randomized Trial of Fluticasone in Bronchial Premalignancy
The purpose of this study is to assess the efficacy of fluticasone on the development of lung cancer in smokers
- Trial name
- NCT00407264
- Testing
- Fluticasone propionate
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Human Papillomavirus Infection
Randomized Trial of Alternative Quadrivalent Human Papilloma Virus (HPV) Vaccination Schedules in a University Setting
This is a randomized, open label trial of HPV (human papilloma virus) vaccine, comparing an on-time administration of the third dose with delayed administration of the third dose.
- Trial name
- NCT00572832
- Testing
- Quadrivalent human papillomavirus vaccine on-time administration, Quadrivalent human papillomavirus vaccine delayed administration
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Male Adults
Bioequivalence Between Single Administration of ASC-01 (Aripiprazole/Sertraline Combination Drug) and Concomitant Single Administration of Aripiprazole and Sertraline, and Food Effect on Pharmacokinetics of ASC-01 in Healthy Male Adults
To investigate the bioequivalence of aripiprazole between administration of one ASC-01 tablet (aripiprazole 3 mg/sertraline 100 mg combination drug) and concomitant administration of one aripiprazole 3-mg tablet and two…
- Trial name
- NCT03342963
- Testing
- ASC-01, Aripiprazole and sertraline
- Where
- Japan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Postpartum Hemorrhage
Active Versus Expectant Management of the Third Stage of Labor
The purpose of this study is to determine if giving oxytocin immediately after delivery causes less bleeding, transfusion needs and hastens delivery of placenta.
- Trial name
- NCT00473707
- Testing
- Active management of the third stage of labor, Expectant management of the third stage of labor, Oxytocin and gentle cord traction with fundal massage
- Where
- United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Chronic Periodontitis
Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects
A clinical and radiographic evaluation of 2 regenerative techniques, bioresorbable membrane and bone allograft for management of periodontal intrabony defects.
- Trial name
- NCT02679209
- Testing
- Demineralized bone matrix in putty form, Amnion chorion membrane
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Language Disorders
China Obstetrics and Gynecology Journal Club
The purpose of this study is to determine if an intensive journal club based on articles and materials provided on the journal Obstetrics and Gynecology Website improves written and spoken comprehension of medical English in a…
- Trial name
- COG-JOCS (NCT01844609)
- Testing
- Self Study Journal Club, Intensive Journal Club
- Where
- 2 sites in United States, China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Post Operative Pain, Apical Periodontitis
Post-operative Pain After Different Irrigation and Disinfection Methods in Single-rooted Teeth
This randomized clinical trial aimed to evaluate post-operative pain (PP) in single-rooted teeth with asymptomatic apical periodontitis following final irrigation with sonic activation systems (EDDY and EndoActivator), with and…
- Conditions
- Post Operative Pain, Apical Periodontitis, Asymptomatic Infections
- Trial name
- NCT07170098
- Testing
- EDDY sonic irrigation system, EndoActivator (EA) sonic irrigation system, 980-nm diode laser
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Biruni University
Meningitis, Meningococcal
Study Evaluating the Safety, Immunogenicity and Tolerability of Meningococcal Group B Vaccine in Healthy Adults
To determine the safety \& immunogenicity of a potential vaccine against meningococcal B disease
- Trial name
- NCT00297687
- Testing
- MnB rLP2086
- Where
- 3 sites in Australia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Healthy
The Impact of Local Anesthetic Dilution on Possible Blinding for Nerve Blocks
This study aims to determine the appropriate dosage of a placebo anesthetic to enable future placebo-controlled studies that can more accurately examine the effects of nerve blocks.
- Trial name
- NCT06668116
- Testing
- Ropivacaine 0,1%
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
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