Clinical trials: Randomized Clinical Trial
Inflammation, Smoking Cessation
Screening and Multiple Intervention on Lung Epidemics
This prospective randomized pilot trial will evaluate a multiple intervention program of prevention in lifelong smokers aiming at reduction of chronic inflammation status through treatment with low-dose acetylsalicylic acid…
- Conditions
- Inflammation, Smoking Cessation, Diet Modification, Physical Activity
- Trial name
- SMILE (NCT03654105)
- Testing
- Cytisine, Acetylsalicylic acid, Diet Modification and Physical Activity Increase
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Lactation Suppressed
Lactation Inhibition, the Efficiency of Vitamin B6 Versus Cabergoline
Some mothers may seek lactation suppression on personal, social, or medical grounds. To reduce congestion symptoms and shorten the duration of milk production lactation suppression can be done pharmacologic or non-pharmacologic.
- Trial name
- NCT05024422
- Testing
- Cabergoline, Pyridoxine
- Where
- Israel
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Composite Resins, Dental Caries Class II
Bulk-Fill Composite Restorations: Clinical Evaluation
This randomized controlled clinical study aims to evaluate the clinical performance of five different bulk-fill composite materials representing distinct technological approaches according to the World Dental Federation (FDI)…
- Trial name
- NCT07518537
- Testing
- Thermoviscous bulk-fill composite restoration, Sonic-activated bulk-fill composite restoration, Flowable bulk-fill composite restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Sleep Quality, Older Adults (65 Years and Older)
Effect of Health Promotion Model-Based Oculomotor Exercise Program on Sleep Quality in Older Adults
The goal of this clinical trial is to investigate the effect of a Health Promotion Model-based oculomotor exercise program on sleep quality among older adults living in a nursing home.
- Trial name
- NCT07261124
- Testing
- Oculomotor Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Soft Tissue Augmentation
The Use of a Porcine Collagen Matrix for the Prevention of Buccal Bone Wall Resorption During Implant Placement in the Aesthetic Zone.
Aim: To provide a comparative assessment of the clinical and radiographic effect of porcine collagen matrix when placed buccally at the time of single implant placement in the aesthetic zone vs autogenous connective tissue graft…
- Trial name
- NCT06622759
- Testing
- CTG, Collagen Matrix, Control group
- Where
- Greece
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Ebolavirus Disease
VSV-ZEBOV Geneva Vaccine Trial
The hemorrhagic fever resulting from Ebola infection is frequently fatal; the current Ebola outbreak, still in its ascendant phase, has a mortality rate over 50%. There is no proven therapy or prevention available at this time.
- Trial name
- VSV-ZEBOV (NCT02287480)
- Testing
- VSV-ZEBOV
- Where
- Switzerland
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Contraceptive Behavior, Self Administration
Impact of Self-Care Family Planning Services on Health and Development in South Sudan (Family Planning Impact Lab)
Since 2019, the International Rescue Committee (IRC) has led family planning programming under the Women's Integrated Sexual Health (WISH) program, funded by the United Kingdom's Foreign, Commonwealth, and Development Office.
- Trial name
- FPIL (NCT07888296)
- Testing
- Self-Managed Contraceptive Care, Standard Family Planning Services (WISH-2)
- Where
- South Sudan
- Volunteers
- 2,736 people, healthy volunteers welcome
- Sponsor
- Guttmacher Institute
Pain
Impact of Liposomal Bupivacaine Administered Following Placement of a Transobturator Suburethral Sling
Liposomal bupivacaine or placebo will be administered at the end of a transobturator midurethral sling to determine if there is a difference in a patient's perceived postoperative pain.
- Trial name
- NCT02591888
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Tension-Type Headache, Cervicogenic Headache
The Classification and Treatment of Myofascial Headache: a Cross-sectional Study and Randomized Controlled Trial.
This project comprises two studies; a cross-sectional study and a randomized controlled trial. 1. The goal of the cross-sectional study is to compare multiple outcome parameters in different headache types: tension type (TTH)…
- Conditions
- Tension-Type Headache, Cervicogenic Headache, Myofascial Headache
- Trial name
- COMPHAS_RCT (NCT06100588)
- Testing
- Dry Needling, Manual therapy
- Where
- Belgium
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University Ghent
Procedural Pain Relief, Virtual Reality
AI-Generated Video Distraction Via Virtual Reality for Fear and Pain During Pediatric Circumcision
This randomized controlled trial evaluated the effect of artificial intelligence-generated video distraction delivered via virtual reality on procedural fear and pain in children undergoing circumcision.
- Conditions
- Procedural Pain Relief, Virtual Reality, Fear, Child
- Trial name
- NCT07824427
- Testing
- AI-Generated Video Distraction via Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Progesterone, Luteal Phase Support
Patient's Preferences About Subcutaneous or Vaginal Progesterone Administration for Luteal Phase Support
Luteal phase support in "in vitro fertilization" (IVF) cycles has been shown to improve pregnancy rates and became a standard of treatment, and progesterone is the first choice considering its safety profile and effectiveness.
- Conditions
- Progesterone, Luteal Phase Support, In Vitro Fertilization
- Trial name
- PROPER-1 (NCT03734770)
- Testing
- Subcutaneous Progesterone, Vaginal progesterone
- Where
- Italy
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Edentulous Mouth
Retention of Computer Aided Design and Computer Aided Manufacturing Titanium Versus Co/Cr Single Dentures.
Steps in short: Undergoing the conventional steps of maxillary single denture construction till the step of framework construction that will be designed and constructed using CAD/CAM after optical scanning of the master cast ( 2…
- Trial name
- NCT03675594
- Testing
- CAD/CAM titanium denture base, CAD/CAM cobalt/chromium denture bases
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Newborn Morbidity, Simulation Training
Educational Strategy in Exchange Transfusion
Abstract Background: Exchange transfusion is a highly complex procedure that requires high levels of expertise. Paediatricians trainees do not have adequate training because opportunities to perform this procedure in practice are…
- Conditions
- Newborn Morbidity, Simulation Training, Telemedicine, Assessment, Self
- Trial name
- INTEXUS (NCT04070066)
- Testing
- Digital didactic environment, • Simulated scenario
- Where
- Colombia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de la Sabana
Vaccines, Pneumococcal
Study to Evaluate a 13-valent Pneumococcal Conjugate Vaccine in Infants.
The purpose of this study is to assess the safety, tolerability and immunogenicity of a 13-valent pneumococcal conjugate (13vPnC) vaccine compared to Prevenar (7vPnC), when given concomitantly with routine pediatric vaccinations…
- Trial name
- NCT00368966
- Testing
- 13-valent Pneumococcal Conjugate Vaccine, 7-valent Pneumococcal Conjugate Vaccine
- Where
- 41 sites in Spain
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
HIV Infections
Safety and Effectiveness of HIV-1 DNA Plasmid Vaccine and HIV-1 Recombinant Adenoviral Vector Vaccine in HIV-Uninfected, Circumcised Men and Male-to-Female (MTF) Transgender Persons Who Have Sex With Men
The purpose of this study is to determine the safety and efficacy of a VRC DNA/rAd5 vaccine regimen in healthy, circumcised men and male-to-female (MTF) transgender persons who have sex with men.
- Trial name
- NCT00865566
- Testing
- DNA plasmid vaccine, Recombinant adenoviral serotype 5 (rAD5) vector vaccine
- Where
- 22 sites in United States
- Volunteers
- 2,504 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Educational Activities
Assessment of Nursing Students' Performance During Guided Debriefing With the Lasater Clinical Judgement Rubric
I invite you to participate in the study entitled Use of debriefing as a training tool in simulation, of which Montserrat Faro-Basco is not the main researcher.
- Trial name
- SIM_LCJR (NCT06035822)
- Testing
- Debriefing with TeamGAINS
- Where
- Spain
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Vic - Central University of Catalonia
Laparoscopic Cholecystectomy
Comparison Between Dexmedetomidine and Fentanyl As an Adjuvant to Bupivacaine in the Paravertebral Nerve Block in Laparoscopic Cholecystectomy for Postoperative Analgesia: Randomized Comparative Clinical Trial.
Laparoscopic cholecystectomy is one of the most common surgeries today, cause it has many advantages over open cholecystectomy. Although these advantages pain remains a big problem after laparoscopic cholecystectomy which causes…
- Trial name
- NCT06752629
- Testing
- Bupivacaine and Dexmedetomidine, Bupivacaine and Fentanyl
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tuberculosis, HIV
TMC207-TiDP13-C110: Interaction Study With Lopinavir/Ritonavir in Healthy Volunteer
The purpose of this Phase I, open-label, randomized crossover trial is to investigate the pharmacokinetic interaction between steady-state lopinavir/ritonavir and single-dose TMC207 in healthy volunteers.
- Trial name
- NCT00828529
- Testing
- TMC207
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Gingival Black Triangle
Restoring Black Triangle With Bioclear Matrix Versus Celluloid Conventional Matrix Method
Assessment of bioclear matrix and injection molding technique against conventional celluloid matrix technique in management of black triangle.
- Trial name
- RBBCM (NCT04482790)
- Testing
- Conventional celluloid matrix technique in management of black triangle, Bioclear cervical matrix with injection molding technique
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Smoking Cessation
Effectiveness of WhatsApp Online Group Discussion for Smoking Relapse Prevention
This study aims to examine the effectiveness and cost-effectiveness of WhatsApp group discussion for smoking relapse prevention.
- Trial name
- NCT03760224
- Testing
- WhatsApp group, SMS group
- Where
- Hong Kong
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
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