Clinical trials: Randomised Controlled Trial
COVID-19 Infection
Trial to Determine the Efficacy/Safety of Plitidepsin vs Control in Patients With Moderate COVID-19 Infection
Treatment of patients hospitalised for management of moderate COVID-19 infection
- Trial name
- Neptuno (NCT04784559)
- Testing
- Plitidepsin, Dexamethasone, Remdesivir
- Where
- 28 sites in Brazil, Bulgaria and 6 more
- Volunteers
- 205 people
- Sponsor
- PharmaMar
Arcuate Uterus
A Randomised Controlled Trial of Hysteroscopic Resection of Mild Septum/Arcuate Uteri.
At least 82 cases of recurrent miscarriage women with a diagnosis of arcuate uterus, confirmed by three-dimensional intra-vaginal sonography (3D-TVS) and hysteroscopy, will be recruited.
- Trial name
- NCT03384082
- Testing
- hysteroscopic treatment
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Gingival Recession
A Comparision of Collagen Matrix and Connective Tissue Graft With Modified Coronally Advanced Tunnel for Root Coverage
Recently porcine derived bioresorbable collagen matrices have shown predictable outcomes for augmenting keratinzed gingiva , improved wound healing, recession coverage in localized gingival recessions and multiple recession…
- Trial name
- NCT02876562
- Testing
- root coverage with collagen matrix
- Where
- India
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Failed Induction (of Labor) by Oxytocin
Continuous Oxytocin Infusion Versus Pulsatile Intravenous Oxytocin for Augmentation of First Stage of Labor
Comparing continuous intravenous oxytocin infusion with pulsatile administration of intravenous oxytocin for augmentation of the first stage of labor.
- Trial name
- NCT02723461
- Testing
- Pulsatile Oxytocin, Continuous Oxytocin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Acute Pain
Efficacy of Pericapsular Nerve Group Block
Hip fracture is a common orthpaedic problem especially in elderly population. Fascia iliaca compartment block (FICB) and femoral nerve block are well-established technique as part of peri-operative multimodal analgesia for hip…
- Trial name
- NCT05154318
- Testing
- Pericapsular Nerve Group Block, Fascia iliaca compartment block
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Functional Motor Disorder
Self-help and Education on the Internet for Functional Motor Disorders
A randomised trial to the effect of a newly developed education and self help intervention for patients with a functional motor disorder on general health, quality of life, illness perception, symptom severity and other secondary…
- Trial name
- SHIFT (NCT02589886)
- Testing
- Education and self-help internet intervention
- Where
- Netherlands
- Volunteers
- 189 people
- Sponsor
- University Medical Center Groningen
Cataract, Surgery
Femtosecond Laser Assisted Cataract Surgery in The NHS
This study aims to examine the health economic impact of adopting femtosecond laser technology to assist high volume cataract surgery (FLACS) within a state-funded healthcare system, the National Health Service (NHS).
- Trial name
- NCT02825693
- Testing
- Conventional cataract surgery (phacoemulsification), Femtosecond laser assisted cataract surgery
- Volunteers
- 400 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Depression
Incorporating Ecological Momentary Assessment and Personalized Telephone Support Into Group-Based Exercise Intervention for Depressive Symptoms
The objective of this proposed pilot randomized controlled trial is to examine the efficacy and acceptability of using smartphone-delivered ecological momentary assessment (EMA) and personalized telephone support to promote…
- Trial name
- NCT05704504
- Testing
- Group-based exercise intervention with EMA and personalized telephone support (SUP), Group-based exercise intervention (EXE)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Child Anxiety, Parent Anxiety
Parenting With Anxiety: Helping Anxious Parents Raise Confident Children
This is a randomised controlled trial of an intervention to reduce symptoms of anxiety in the children of anxious parents. Parents will participate in an online intervention which helps them develop a calm, consistent, behaviour…
- Conditions
- Child Anxiety, Parent Anxiety, Parental Wellbeing, Child Wellbeing
- Trial name
- PWA (NCT04755933)
- Testing
- Raising Confident Children Course
- Where
- United Kingdom
- Volunteers
- 3,508 people
- Sponsor
- University of Sussex
Smoking &Amp; Tobacco Cessation
Community-based Mobile-assisted Brief Intervention for Smoking Cessation
The goal of this pilot trial is to evaluate the feasibility of a mobile-assisted brief intervention for smoking cessation in community-based individuals in Singapore. Specific aims include: 1.
- Trial name
- NCT07375459
- Testing
- Brief cessation advice + self-help booklet, Opt-out referral, Mobile chat messaging
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Anxiety
The Effect of Virtual Reality Distraction on Preoperative Anxiety in Abdominal Surgery Patients
Hospitalization, medical interventions to be performed, and uncertainties specific to surgical intervention create a certain level of anxiety in the patient.
- Trial name
- NCT05718661
- Testing
- Watching video with virtual glasses, watching video without virtual glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Trakya University
Pain, Postoperative, Postoperative Pain
Intraperitoneal Aerosolized Delivery of a Local Anesthetic for Post Operative Pain Management. A Double Blind, Randomised Controlled Clinical Trial.
The purpose of this study is to determine the effectiveness of aerosolized pain medication (.5% bupivicaine) delivered into the peritoneal cavity after laparoscopic gastric bypass surgery.
- Conditions
- Pain, Postoperative, Postoperative Pain, Abdominal Pain, Obesity
- Trial name
- NCT00286286
- Testing
- Intraperitoneal Aerosolization System, IntraMyst
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Northgate Technologies
Skin to Skin, Premature Newborns
Skin-to-skin Contact During the Transfer From the Delivery Room to the Neonatal Intensive Care Unit: Impact on Very Preterm Infants and Their Parents
Developmental care are recognized as a standard of care for preterm infants in neonatal intensive care units. Regular skin-to skin contacts during the neonatal stay show short and long-term beneficial effects on preterm infants…
- Trial name
- TRANSPAPNEO (NCT05820386)
- Testing
- Skin-to-skin Contact (SSC), Incubator
- Where
- 4 sites in France
- Volunteers
- 118 people
- Sponsor
- University Hospital, Tours
Lower Respiratory Tract Infection, Community Acquired Pneumonia
The Effect of Focused Lung Ultrasonography on Antibiotic Prescribing in General Practice
The goal of this randomised controlled trial is to determine if adults presenting with symptoms of an acute lower respiratory tract infection in general practice where the general practitioner suspects CAP, who have FLUS…
- Trial name
- PLUS-FLUS (NCT06210282)
- Testing
- Focused lung ultrasound (FLUS), Usual Care
- Where
- Denmark
- Volunteers
- 391 people
- Sponsor
- Aalborg University
Stress, Psychological
Urban Care Farming on Living Well and Productive Engagement of Older Adults
The goal of the randomized controlled trials is to learn about the effects of urban farming interventions on older adults' physical, mental, and social well-being of older adults aged 50 to 85 years.
- Trial name
- NCT06277583
- Testing
- Urban care farming
- Where
- 2 sites in Singapore
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Hypercholesterolemia, Combined Hyperlipidemia
Cholesterol-Lowering Effects of Policosanol
Despite undeniable progress in the reduction of morbidity and mortality of coronary heart disease (CHD) prevention is a mainstay for medical intervention.
- Trial name
- NCT00288483
- Testing
- Policosanol
- Sponsor
- Drug Commission of the German Medical Association
Critical Illness
Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Background: Two recent systematic reviews of the literature and meta-analyses have suggested that colloids administration might be deleterious in critically ill patients.
- Trial name
- NCT00318942
- Testing
- Crystalloids, Colloids
- Where
- 67 sites in Belgium, Canada and 3 more
- Volunteers
- 2,857 people
- Sponsor
- University of Versailles
Analgesia
Analgesic Effect of Bupivacaine Plus Ketamine Versus Bupivacaine Alone in Transversalis Fascia Plane Block
The objective of this study is to compare the efficacy of transversalis fascia plane block using bupivacaine and ketamine versus bupivacaine alone for pain management after cesarean section under spinal anaesthesia.
- Trial name
- TFBP (NCT06935669)
- Testing
- Ketamine, Bupivacaine, Bupivacain
- Where
- Egypt
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Covid19, Immuno-Deficiency
Preemptive Use of Convalescent Plasma for High-risk Patients With COVID-19
Convalescent plasma therapy has been recognized as safe and plasma transfusion is routinely used in clinical practice. A recent study showed that early administration of convalescent plasma can decrease the risk of complications…
- Conditions
- Covid19, Immuno-Deficiency, Old Age; Debility
- Trial name
- NCT04836260
- Testing
- SARS-CoV-2 convalescent plasma
- Where
- 4 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
HIV Infection, HIV
A Clinical Trial Comparing the Tolerability of Etravirine to Efavirenz in Combination With 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Treatment-naive HIV-1 Infected Patients
The purpose of this study is to compare the neuropsychiatric adverse event profiles of etravirine 400mg once daily versus efavirenz 600mg once daily, in combination with 2 N(t)RTIs, in approximately 150 treatment-naÃ-ve HIV-1…
- Conditions
- HIV Infection, HIV, Acquired Immunodeficiency Syndrome
- Trial name
- SENSE (NCT00903682)
- Testing
- etravirine (ETR, TMC125), efavirenz (EFV)
- Where
- 33 sites in Austria, Denmark and 9 more
- Volunteers
- 157 people
- Sponsor
- Janssen-Cilag International NV