Clinical trials: Randomised Controlled Trial
Compliance, Patient
Treatment of Latent Tuberculosis in Socially Marginalised Citizens
An open-label, randomised controlled trial comparing compliance to treatment for latent tuberculosis infection in socially marginalised citizens.
- Trial name
- DOT-LTBI (NCT03266991)
- Testing
- Rifapentine, Isoniazid
- Where
- 2 sites in Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Dental Plaque
Effect of the SIMS Programme on Preschool Children's Oral Hygiene Level
This is a cluster randomised control trial targeting 5-6-year-old children and their parents in Kampar district, Perak, Malaysia for a period of 6 months.
- Trial name
- SIMSP (NCT04339647)
- Testing
- The SIMS programme
- Where
- Malaysia
- Volunteers
- 653 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Tooth Extraction, Socket Preservation
Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars
Different materials and techniques are employed for socket preservation to reduce the alveolar bone resorption in both the horizontal and vertical dimensions as well as the soft tissue collapse after tooth extraction.
- Trial name
- NCT06936358
- Testing
- Control, A-PRF, I-PRF
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Hams Hamed Abdelrahman
Kidney Failure, Chronic, Hyperphosphatemia
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested.
- Trial name
- PHOSPHATE (NCT03573089)
- Testing
- Liberal phosphate target, Intensive phosphate target
- Where
- 126 sites in Australia, Brazil and 7 more
- Volunteers
- 3,600 people
- Sponsor
- The University of Queensland
Keloid, Stem Cell
Comparison of Keloid Volume and Symptoms Reduction Between Intralesional Umbilical-Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide Injection as Keloid Therapy: A Randomised Controlled Trial
This study is a double-blind randomized controlled trial (RCT) examining the effect of intralesional injection of umbilical cord-derived mesenchymal stem cells (UC-MSC), umbilical cord-derived conditioned medium (UC-CM), or…
- Trial name
- NCT05887804
- Testing
- umbilical cord-derived mesenchymal stem cells (UC-MSC), umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM), Triamcinolone Acetonide (TA)
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
Orthopedic Disorder
Accelerometry and Rehabilitation After Knee Replacement Study (ARK)
Total knee replacement (TKR) is a successful and cost-effective treatment for end-stage arthritis. Its usage is increasing due to changing population demographics and quality of life (QoL) expectations.
- Trial name
- ARK (NCT05412940)
- Testing
- Remote monitoring of home-based exercises following knee replacement using a wearable sensor, Standard Care (in control arm)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Neurologic Disorder
The Effect of Proprioceptive Neuromuscular Facilitation on Haemodynamic Responses in a Neurological Intensive Care
Although there are studies examining the effect of actively performed PNF exercises on haemodynamic responses in intensive care patients and healthy individuals, there are no studies investigating their effect on circulation and…
- Trial name
- NCT07524790
- Testing
- Proprioceptive Neuromuscular Facilitation Exercises, Passive Range of Motion Exercises
- Volunteers
- 24 people
- Sponsor
- Abant Izzet Baysal University
Chronic Obstructive Pulmonary Disease, Inflammation
Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
COPD is a progressive pulmonary disease that is characterized by an inflammatory process in the airways and the lungs which leads to progressive airway obstruction. The inflammation is associated with tissue loss and remodelling.
- Conditions
- Chronic Obstructive Pulmonary Disease, Inflammation, Pulmonary Emphysema
- Trial name
- NCT00857038
- Testing
- Doxycycline
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Center Alkmaar
Stroke
Active Somatosensory Exercise for Chronic Stroke
The current work aims to examine whether the proposed rehabilitation training or exercise will eventually yield improvements in both motor and somatosensory aspects at one goal.
- Trial name
- ActSens (NCT04490655)
- Testing
- Active somatosensory training, Motor-based training
- Where
- 2 sites in Singapore
- Volunteers
- 9 people
- Sponsor
- Nanyang Technological University
3 or More Chronic Conditions for 6 Months or Longer, 5 or More Regular Drugs
OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People
The objective of this Randomised Controlled Trial (RCT) is to evaluate whether the Systematic Tool to Reduce Inappropriate Prescribing (STRIP) including STRIP assistant (STRIPA) implemented by an appropriately qualified team will…
- Trial name
- OPERAM (NCT02986425)
- Testing
- STRIP intervention, Control
- Where
- 4 sites in Belgium, Ireland and 2 more
- Volunteers
- 2,009 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Borderline Personality Disorder
Physical Activity in People With Borderline Personality Disorder (PABORD)
The aim of this Randomised Controlled Trial (RCT) is to test the effects of a structured physical activity (PA) program on symptoms in female outpatients aged 18 to 40 years with a diagnosis of Borderline Personality Disorder…
- Trial name
- PABORD (NCT06461104)
- Testing
- Structured Physical Activity Programme, Psychoeducational Programme
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Dental Caries in Children
The Effectiveness of Dental Health Home Visits on Caries Prevention in Young Children
Tooth decay affects 75% of Malaysian preschool children, most of which remain untreated. Untreated decay can cause pain, and impair nutritional status and physical growth.
- Trial name
- NCT04885348
- Testing
- Intervention Group (Dental Home Visits + Dental Home Education Leaflets), Control Group (Dental Home Education Leaflets)
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Ministry of Education, Malaysia
Drug Interactions
S(+)-Ibuprofen Effects on Asprin Treated Volunteers
The purpose of this clinical trial is to determine whether S(+)-ibuprofen affect the platelet inhibition under steady state acetylsalicylic acid conditions.
- Trial name
- NCT00442585
- Testing
- S(+)-ibuprofen
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gebro Pharma GmbH
Active Root Caries, Over Sixty-five Years of Age
Treatment of Root Caries in an Older Irish Population.
This study will involve filling teeth which have decay on their roots with three different filling materials. Patients will attend Cork University Dental School and hospital for a clinical examination and to complete a…
- Conditions
- Active Root Caries, Over Sixty-five Years of Age, >=Two Carious Root Surfaces Per Patient
- Trial name
- NCT01866059
- Testing
- Calcium silicate cement, Glass Ionomer Cement, Resin Modified Glass Ionomer Cement
- Where
- Ireland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University College Cork
Pregnancy
Effectiveness of a Breathing and Relaxation Technique in Antenatal Education
The aim of this randomised controlled trial is to compare the effects of an antenatal education class including a breathing and relaxation technique on self-efficacy compared to a standard antenatal education class without a…
- Trial name
- BreLax (NCT06003946)
- Testing
- BreLax: Antenatal education class, Standard care (control)
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- Zurich University of Applied Sciences
Multiple Sclerosis, Fatigue
Bright Light Therapy as Possible Treatment Option for MS-Fatigue
This study aims to investigate the effect of a 2-week trial of bright light therapy (BLT, 10.000 lx) on fatigue in multiple sclerosis (MS) patients.
- Trial name
- NCT04681586
- Testing
- bright light therapy, dim red light
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Medical University of Vienna
Hip Osteoarthritis, Overweight and Obesity
Effects of a Weight Loss Program in People With Hip Osteoarthritis
This randomised controlled trial will compare the effects of a weight loss and exercise program to exercise only on clinical outcomes in 100 people with hip osteoarthritis (OA) and overweight or obesity.
- Trial name
- ECHO (NCT04825483)
- Testing
- Weight loss, Exercise
- Where
- Australia
- Volunteers
- 101 people
- Sponsor
- University of Melbourne
Low Back Pain
Retention in Physically Demanding Jobs With Low Back Pain: A Randomised Controlled Trial (GoBack)
Low back pain (LBP) is a recognized public health problem with high life time prevalence. Medical treatment may reduce the physical and mental discomfort, while it has not been able to improve the possibilities for retaining or…
- Trial name
- GoBack (NCT02015572)
- Testing
- Occupational intervention, Usual care
- Where
- Denmark
- Volunteers
- 302 people
- Sponsor
- Frederiksberg University Hospital
Medically Assisted Procreation (MAP), Oocyte Retrieval
Monocentric Randomised Controlled Trial to Assess Whether Virtual Reality Reduces the Use of Hypnotic Agents During IVF/ICSI Oocyte Retrieval
Over the last few years, audiovisual distraction devices using animation, films and 3D immersion have been developed, with the aim to provide patients with a relaxing experience that disconnects them from the operating…
- Trial name
- REVAHPOVO (NCT07190729)
- Testing
- Propofol sedation + Audiovisual distraction, Propofol sedation
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Overconsumption, Obesity
Nutri-score Labels on the Nutritional Quality of Out-of-home Food Selection
Participants will be asked to make hypothetical food choices in an online simulation study of an OOH delivery app. This study will be a three-arm randomised controlled design, with intervention type as the 3-level grouping…
- Trial name
- NCT07423845
- Testing
- Labelling condition - Calorie labelling, Labelling condition - Nutri-score labelling, Labelling condition: Nutri-score labelling + educational intervention
- Where
- United Kingdom
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- University of Liverpool