Clinical trials: Randomised Clinical Trial
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping…
- Trial name
- CORDMILK (NCT03657394)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Enamel Caries
Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents
Medical Treatment of Early-Enamel Carious Lesion using Different Remeneralizing agents
- Trial name
- NCT05296213
- Testing
- Silver diamine fluoride- potassium iodide, Casein phosphopeptide amorphous calcium phosphate, experimental tricalcium silicate
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Prostate Cancer Patients
A Randomised Trial of Cabazitaxel, Docetaxel, Mitoxantrone or Satraplatin (CDMS) Plus Surgery for Prostate Cancer Patients
Current agents administered in therapeutic regimens of prostate cancer employ different mechanisms to eliminate neoplastic cells by inducing substantial apoptosis and causing tumor regression.
- Trial name
- NCT03258320
- Testing
- Cabazitaxel, Docetaxel, Mitoxantrone or Satraplatin
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Xerostomia, Dry Mouth
Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial
The goal of this clinical is to assess the efficacy of natural enzymes mouthwash in the treatment of xerostomia (dry mouth). The main questions it aims to answer are: (1) the efficacy of natural enzymes mouthwash in the…
- Trial name
- NCT05640362
- Testing
- Natural enzymes mouthwash, Benzydamine mouthwash
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Urologic Diseases, Gastrointestinal Diseases
PACT Programme for Parents of Children With SHCN
This randomised controlled trial aims to determine the efficacy of a 12-week, smartphone-based Prosocial-orientated Acceptance and Commitment Training (PACT) programme plus age-appropriate positive parenting advice on the…
- Conditions
- Urologic Diseases, Gastrointestinal Diseases, Vascular Diseases, Cleft Lip and Palate
- Trial name
- NCT05467527
- Testing
- Prosocial-orientated Acceptance and Commitment Training plus positive parenting advice, Positive parenting advice
- Where
- 2 sites in Hong Kong
- Volunteers
- 196 people
- Sponsor
- Chinese University of Hong Kong
Healthy
A Study to Assess the Pharmacokinetics of Sorafenib in Mesoporous Magnesium Carbonate (DPH001) Compared to Nexavar® (sorafenib) in Healthy Volunteers
The study aims to assess the pharmacokinetics and safety of DPH001, an amorphous formulation of sorafenib, compared to Nexavar® in healthy volunteers.
- Trial name
- NCT06797427
- Testing
- DPH001, Nexavar (Sorafenib)
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Disruptive Pharma
Behavior and Behavior Mechanisms, Gingivitis
A 8-month Study on the Use of Intra-oral Camera and Text Messages on Gingivitis Control
To investigate the effects of using an intra-oral camera (IOC) during supportive periodontal therapy, and oral hygiene mobile text messages (SMS) between appointments on clinical, behavioral and psychological parameters of…
- Trial name
- NCT03439969
- Testing
- Mobile Text Messages, Intra Oral Camera
- Volunteers
- 233 people
- Sponsor
- University of Lisbon
Irreversible Pulpitis
Post Operative Pain and Oral Health Related Quality of Life Following Pulpotomy VS Extraction of Permanent First Molar
The goal of this clinical trial is to compare between post operative pain and oral health related quality of life in participants receiving two treatments for first permanent mandibular molars with poor prognosis.
- Trial name
- NCT06420583
- Testing
- MTA pulpotomy, Extraction
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy Children
Happy Homework 2.0: Effects on 24-hour Movement Behaviours in Children
The aim of this research is to trial a new version of Happy Homework (HH) on children and parent health outcomes. HH was previously a paper-based 8-week program designed to encourage positive eating habits, physical activity, and…
- Trial name
- NCT07631754
- Testing
- Happy Homework 2.0
- Where
- United Kingdom
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of the West of Scotland
Gingival Recession
Evaluation of Two Types of Matrix (Mucograft® and Mucoderm®) Associated With Coronally Advanced Flap
The aim of this study is to evaluate clinically the results of two types of matrix (Geistlich Mucograft® and Mucoderm®) associated with CAF technique for the treatment of gingival recessions.
- Trial name
- NCT03667105
- Testing
- CAF, MC, XDM
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Healthy
Investigating the Acute Effects of Blueberry (Poly)Phenols on Vascular Function and Cognition in Healthy Individuals.
This study aims to determine the effect of blueberry (poly)phenol vs placebo on vascular function and cognitive performance with an insight into cerebral blood flow velocity changes, across all ages of the general healthy…
- Trial name
- BluLife (NCT03592966)
- Testing
- Wild Blueberry Powder
- Where
- United Kingdom
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- King's College London
Language Disorder
Efficacy of AMALS in Treating Language Impairment in Children
The goal of this proposal is to examine the efficacy of a manualized treatment intervention, AMALS: Addressing Multiple Aspects of Language Simultaneously, which is designed to remediate semantic, morphological, and syntactic…
- Trial name
- AMALS (NCT00840060)
- Testing
- AMALS, DTA
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Lamar University
Renal Cell Carcinoma, Zero Ischemia
Zero Ischemia Laparoscopic Radio Frequency Ablation Assisted Enucleation of Renal Cell Carcinoma With T1a Stage
To evaluate the feasibility and efficiency of zero ischemia laparoscopic radio frequency ablation assisted enucleation of T1a renal cell carcinoma in comparison with the conventional laparoscopic partial nephrectomy.
- Trial name
- NCT01838720
- Testing
- zero ischemia laparoscopic RFA assisted TE, ischemia
- Where
- China
- Volunteers
- 90 people
- Sponsor
- RenJi Hospital
Reflex Syncope
Cardioinhibitory Reflex Syncope. Permanent Pacemaker Therapy or Cardioneuroablation?
Reflex syncope is the most common form of syncope. It can lead to injuries and affect quality of life. Nonpharmacological and medical therapies have limited effectiveness.
- Trial name
- PANACEA (NCT05855603)
- Testing
- Cardioneuroablation, Permanent pacemaker therapy
- Where
- 10 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Oxidative Stress, Muscle Fatigue
Effect of Grape Juice Consumption on the Parameters of Oxidative Stress and Muscle Fatigue in Judo Athletes
This project aims to evaluate if after 14 days of grape juice ingestion there is improvement of the parameters of strength, fatigue and oxidative stress in judo fighters.
- Conditions
- Oxidative Stress, Muscle Fatigue, Polyphenol, Free Radical Oxidation of Tissue
- Trial name
- NCT03186573
- Testing
- Grape juice, Maltodextrin
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Cardiac Valve Disease, Coronary Artery Disease
The PRE-OP ENERGY Trial
The PRE-OP ENERGY Trial proposes to test the overarching hypothesis that a pre-surgery high energy diet will protect patients against organ damage during cardiac surgery with cardiopulmonary bypass.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- NCT04015973
- Testing
- High energy diet
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Leicester
Malaria, Chemoprophylaxis
Dihydroartemisinin-piperaquine for Seasonal Malaria Chemoprophylaxis in Tanzania
Background: Malaria prevalence has declined globally following the scale-up of the interventions, including insecticide-treated bed-net, indoor residual spraying, and prompt diagnosis and treatment with artemisinin-based…
- Conditions
- Malaria, Chemoprophylaxis, Underfive Children
- Trial name
- SMC-DP (NCT05874869)
- Testing
- Dihydroartemisinin-piperaquine
- Where
- Tanzania
- Volunteers
- 13,800 people
- Sponsor
- Richard Mwaiswelo
Facial Blushing
Thoracoscopic Sympathectomy for Blushing
To determine outcome and side effects following thoracoscopic sympathectomy in patients treated for disabling isolated facial blushing and investigate if there are any significant differences between two different routine…
- Trial name
- NCT00225069
- Testing
- Level of sympathectomy
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Traumatic Rotator Cuff Tear
Surgery Versus PhysiothErapist-leD Exercise for Traumatic Tears of the Rotator Cuff
The SPeEDy study is a parallel group, pilot and feasibility randomised controlled trial (RCT) with integrated Quintet Recruitment Intervention (QRI) and further qualitative interviews.
- Trial name
- SPeEDy (NCT04027205)
- Testing
- Physiotherapist-led exercise, Surgical repair
- Where
- United Kingdom
- Sponsor
- Keele University
Chronic Obstructive Pulmonary Disease
Steroid Withdrawal Intervention in Fife and Tayside
The SWIFT trial is a cluster randomised trial to determine if a patient identification, feedback and inhaled corticosteroid (ICS) withdrawal intervention in primary care can result in more appropriate inhaled corticosteroid use…
- Trial name
- SWIFT (NCT03489746)
- Testing
- ICS withdrawal protocol, Standard care
- Where
- 2 sites in United Kingdom
- Sponsor
- NHS Tayside