Clinical trials: Randomised Clinical Trial
Hysterectomy, Natural Orifice Transluminal Endoscopic Surgery
Vaginal NOTES Hysterectomy Versus Vaginal Hysterectomy
Rationale: Natural orifice transluminal endoscopic surgery (NOTES) is a minimal invasive technique using the natural body orifices like stomach, oesophagus, bladder, rectum and vagina to access the human body for surgery.
- Conditions
- Hysterectomy, Natural Orifice Transluminal Endoscopic Surgery, Vaginal Hysterectomy
- Trial name
- VANH (NCT04886791)
- Testing
- Vaginal NOTES hysterectomy, Vaginal hysterectomy
- Where
- 2 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Zuyderland Medisch Centrum
Vomiting
Hyoscine Butyl-bromide Versus Ondansetron for Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia
overall incidence of intraoperative nausea and vomiting(IONV) during regional anesthesia for cesarean section is extremely variable, up to 80 percent , depending on the anesthetic technique used (spinal, epidural or combined…
- Trial name
- NCT04785118
- Testing
- Hyoscine N Butylbromide, Ondansetron, Saline
- Where
- Egypt
- Volunteers
- 165 people
- Sponsor
- Assiut University
Influenza, Human
Tropical Influenza Control Strategies for the Elderly
TROPICS1 is a randomized, observer-blind, active comparator-controlled, single-center, Phase IV trial in 200 participants aged ≥65 years.
- Trial name
- TROPICS1 (NCT02655874)
- Testing
- Influenza vaccine, Tetanus-diphtheria-pertussis vaccine
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Helicobacter Pylori
Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans
The primary objective of this study is to compare the Helicobacter pylori (H. pylori) eradication rate following empiric bismuth-based quadruple therapy (BQT) versus a personalized H.
- Trial name
- VA EradicateHP (NCT07104318)
- Testing
- Bismuth quadruple therapy with optimized proton pump inhibitor (PPI), Bismuth quadruple therapy with standard proton pump inhibitor (PPI), Clarithromycin triple therapy with optimized proton pump inhibitor (PPI)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- VA Office of Research and Development
Molar Incisor Hypomineralization
HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING LOW LEVEL LASER IN CHILDREN
Molar Incisor Hypomineralisation (MIH) is a qualitative defect of enamel that shows asymmetrically involvement of one to four on first permanent molars (FPM) with or without incisor teeth involvement.
- Trial name
- NCT06154733
- Testing
- Photobiomodulation usinf low level laser therapy, Resin-based sealant, Glass ionomer sealant
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Stroke
A Very Early Rehabilitation Trial
Phase 3, multicenter, international randomized controlled trial of a Very Early Mobilization(VEM) care rehabilitation protocol compared to standard post stroke care (SC).
- Trial name
- AVERT (NCT01846247)
- Testing
- Standard Care + VEM, Standard care
- Where
- Australia
- Volunteers
- 2,014 people
- Sponsor
- Neuroscience Trials Australia
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Atrial Fibrillation (AF)
Redo-Pulmonary Vein Isolation With Versus Without Posterior Wall Ablation - The REDO-PIFPAF-PFA Study
The study will compare two ablation strategies in patients with paroxysmal or persistent atrial fibrillation undergoing repeat ablation using pulsed-field ablation: redo pulmonary vein isolation only versus redo pulmonary vein…
- Trial name
- NCT07745543
- Testing
- Pulmonary vein isolation with posterior wall ablation, Pulmonary vein isolation without posterior wall ablation
- Where
- 5 sites in Switzerland
- Volunteers
- 270 people
- Sponsor
- University Hospital, Basel, Switzerland
Follow-up Study, Medical In-patients
Impact of Medical Follow-up Discharge Package
The post discharge time is a vulnerable time for general medical in-patients, with high rates of adverse events that may cause unnecessary readmissions and even death.
- Trial name
- RECALL-CT (NCT01916876)
- Testing
- Integrated medical follow-up package
- Where
- 2 sites in South Africa
- Sponsor
- University of Cape Town
Dental Caries, Reversible Pulpitis
Assessment of Pain and Anxiety During Infiltration Anesthesia Using Dental Anesthesia Injector Versus Conventional Syringe in Pediatric Patients
This randomized controlled trial is conducted on pediatric dental patients to compare the effectiveness of local anesthesia administered using a dental anesthesia injector device versus the traditional syringe method.
- Trial name
- NCT07101068
- Testing
- Dental Anesthesia Injector, conventional syringe
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Medication Adherence, Self Management
Medication Adherence Enhancement in Heart Transplant Recipients
Medication-related non-adherence increases the risk of rejections and associated graft loss after solid organ transplantation. A randomized controlled intervention will use adherence enhancing strategies out of a larger sample of…
- Conditions
- Medication Adherence, Self Management, Rejection
- Trial name
- NCT00843960
- Testing
- behavioral adaptation and symptom management
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Hannover Medical School
Evaluations, Diagnostic Self
Radiographic Evaluation of Bone Height Gain With Dental Implant Placed Simultaneously With Closed Sinus Lifting Using Hydraulic Lift Technique Versus Summers' Osteotome Technique in Posterior Edentulous Maxilla (RCT)
Radiographic evaluation of bone height gain with dental implant placed simultaneously with closed sinus lifting using hydraulic lift technique versus summers' osteotome technique in posterior edentulous maxilla (RCT)
- Trial name
- NCT04648514
- Testing
- Using of hydraulic lifter device for closed sinus lifting, patient satisfaction evaluation after using hydraulic lifter device
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vulvar Lichen Sclerosus
Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus
This is a prospective, randomized study in women of reproductive age with vulvar lichen sclerosus. Participants will be randomly assigned by investigators using a computer-generated sequence to receive either combined dynamic…
- Trial name
- NCT07363733
- Testing
- Dynamic Quadripolar Radiofrequency (DQRF), Topical high-potency corticosteroid
- Where
- Russia
- Volunteers
- 68 people
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Cesarean Wound; Dehiscence
Skin Closures at Cesarean Delivery, Glue vs Subcuticular Sutures.
The optimal choice of skin closure at cesarean delivery has not yet been determined. This study will compare wound complications and scar healing following cesarean delivery between 2 methods of skin closure: glue (Dermabond®…
- Trial name
- NCT04371549
- Testing
- Glue (Dermabond®; Ethicon, Somerville, NJ)., Monocryl
- Where
- Egypt
- Volunteers
- 79 people
- Sponsor
- Ain Shams Maternity Hospital
Severe Stroke, Acute Stroke
Controlling Hypertension After Severe Cerebrovascular Event
The purpose of this academic lead study is to explore ideal blood pressure targets and optimum individualized anti-hypertension strategies in acute severe stroke.
- Conditions
- Severe Stroke, Acute Stroke, Hypertension
- Trial name
- CHASE (NCT02982655)
- Testing
- Individualized BP lowering
- Where
- 26 sites in China
- Volunteers
- 500 people
- Sponsor
- Xijing Hospital
Acupuncture, Chronic Pelvic Pain, Woman
Acupuncture for Chronic Pelvic Pain
The aim of the study is to assess the effects and safety of acupuncture for moderate to severe chronic pelvic pain in women.
- Trial name
- NCT05223517
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Diabetes Mellitus, Diabetes Mellitus, Type 2
The PACT (Patient Activation Through Conversations) Study
The PACT Study is a cluster randomised trial of a health coach-led patient activation program in type 2 diabetes. The goal of this clinical trial is to evaluate the effectiveness of a health coaching intervention (PACT program)…
- Trial name
- PACT (NCT06444074)
- Testing
- Patient Activation through Conversations (PACT) Program, Usual Care
- Where
- 3 sites in Singapore
- Volunteers
- 432 people
- Sponsor
- National Healthcare Group Polyclinics
Parent-Child Relations, Parenting
ODISEA Trauma: Parental Therapy Dispositive + Videofeedback 3.0
This is a study protocol of a randomized controlled trial, which aims to validate the effectiveness of the ODISEA Trauma intervention (parental thearpy + videofeedback) compared to a control group.
- Conditions
- Parent-Child Relations, Parenting, Parent-child Problem
- Trial name
- NCT04244318
- Testing
- Video-feedback ODISEA 3.0, ODISEA-DTP: parental therapy, Treatment as usual
- Where
- Chile
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Esteban Gómez Muzzio
Healthy, Obesity
A Study to Compare How 2 Different Formulations of Survodutide Are Taken up in the Body When Given by Injection in Healthy Men and Women With and Without Overweight or Obesity
The main objective of this trial is to establish the bioequivalence of survodutide in a pre-filled syringe (reference product [formulation A]) and in a vial (test product [formulation B2]) in male and female trial participants…
- Trial name
- NCT07768813
- Testing
- Survodutide formulation A, Survodutide formulation B2
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Alkasite-based Restorations, Nano-hybrid Resin Composite
Clinical Performance of Alkasite-based Restorations in Children
The aim of this study is to evaluate and compare the clinical performance of alkasite-based resin and nanohybrid composite resin materials in the restoration of occlusal carious lesions in primary molars of children.
- Trial name
- Restorations (NCT07263555)
- Testing
- Alkasite-based composite restorations, Nano-hybrid resin composite
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University