Clinical trials: Raman Spectroscopy
Diabetes Mellitus
Study of a Novel Non-invasive Glucose Monitoring Device
This explorative clinical study has been launched to collect spectral Raman data paired with validated glucose reference values in diabetic patients.
- Trial name
- NCT03782441
- Testing
- Prototype 0.5
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- RSP Systems A/S
Nephrotic Syndrome
Non-invasive Assessment of Mechano-chemical Properties of Urine Proteins by Hybrid Brillouin-Raman Spectroscopy
The proteinuria is widely recognized as a marker of kidney disease severity, as well as the predictor of renal function decline, cardiovascular outcomes, and all-cause mortality.
- Trial name
- NCT04311684
- Testing
- hybrid Brillouin-Raman spectroscopy
- Where
- Kazakhstan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Nazarbayev University
Dermatologic Disorders, Disorder of Cholesterol Metabolism
Confocal Raman Spectroscopy: in Vivo Measurement of Physiological Skin Parameters
The purpose of this study is to I. determine several skin parameters, for example natural moisturizing factor (NMF) and cholesterol, with Raman spectroscopy in vivo and II.
- Trial name
- NCT02854475
- Testing
- Venous blood collection, Raman spectroscopy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Femur Head Necrosis
Modifications of the Subchondral Bone in Aseptic Osteonecrosis of the Femoral Head
In this study, the aim is to identify the modifications responsible for aseptic osteonecrosis of the femoral head and its structural evolution by the association of the micro scanner analysis and Raman spectrometry performed on…
- Trial name
- ONTF (NCT02733900)
- Testing
- femoral head removal
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- Lille Catholic University
Diabetes Mellitus
Performance Study of a Non-invasive Glucose Monitoring Device Prototype
This clinical study has been launched to collect spectral Raman data paired with validated glucose reference values in private homes of subjects.
- Trial name
- NCT03519841
- Testing
- P0.1
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- RSP Systems A/S
Parkinson Disease, Gait, Festinating
Effect of a Progressive Treadmill Training Protocol for Parkinson's Disease
The primary objective of this single-center, no-profit, longitudinal interventional randomized controlled, single-blind trial is to compare the effects of 2 different treadmill training treatments using C-Mill: the experimental…
- Conditions
- Parkinson Disease, Gait, Festinating, Fall Due to Loss of Equilibrium, Gait, Unsteady
- Trial name
- NCT05902065
- Testing
- AVR Treadmill training with C-Mill, Conventional Treadmill training with C-Mill
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Florence
Breast Neoplasm
A Prospective Study to Develop and Clinically Validate an in Vitro Diagnostic Medical Device That Uses Blood to Classify Patients at High Risk for Breast Cancer
EXoPERT has developed a liquid biopsy-based in vitro diagnostic medical device that can diagnose cancer through blood. The in vitro diagnostic medical device for this clinical performance trial is a test device that applies a…
- Trial name
- NCT06672302
- Testing
- ExoPred
- Where
- 3 sites in United States, South Korea
- Volunteers
- 330 people
- Sponsor
- EXoPERT
Barrett Esophagus, Esophageal Cancer
Raman Probe for In-vivo Diagnostics (During Oesophageal) Endoscopy
To develop and endoscopic Raman spectroscopy probe for delivery down and channel in an endoscope to make near instant assessments of the condition of the oesophagus without the need for expensive and distressing tissue removal…
- Trial name
- RaPIDE (NCT03468634)
- Testing
- endoscopy
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Endoscopic Bladder Cancer Diagnosis With Raman
In Vivo Proof-of-principle Study of Raman Spectroscopy in Trial Participants With Bladder Tumours
The purpose with this clinical investigation is to perform Raman spectroscopy inside the vivid bladder and to acquire Raman spectra of normal and tumour bladder tissue, and in a post-processing step to determine the grade of the…
- Trial name
- NCT05124106
- Testing
- Raman Spectrometry
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Sentinel Lymph Node, Breast Cancers
EpCAM-Targeted Surface-Enhanced Raman Spectroscopy Nanotags for Rapid Evaluation of Surgical Margins and Sentinel Lymph Node Metastasis Status in Breast Cancers
For early breast cancer patients, breast-conserving surgery and sentinel lymph node biopsy have emerged as the cornerstone of precision oncology, harmonizing oncologic efficacy with the preservation of breast cosmetics and…
- Conditions
- Sentinel Lymph Node, Breast Cancers, Metastases, Margin Assessment
- Trial name
- NCT07018505
- Testing
- SERS detection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yunnan Cancer Hospital
Crohn Disease, Pediatric Inflammatory Bowel Diseases
Microplastic Analysis in Pediatric Inflammatory Bowel Disease
The goal of this observational study is to measure and compare the presence of microplastics in children with inflammatory bowel disease (IBD) and children without IBD.
- Conditions
- Crohn Disease, Pediatric Inflammatory Bowel Diseases, Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
- Trial name
- MAP-IBD (NCT07141238)
- Testing
- Environmental microplastic exposure
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Chronic Obstructive Pulmonary Disease
Raman Analysis of Saliva as Biomarker of COPD
Chronic Obstructive Pulmonary Disease (COPD) is a debilitating and chronic lung syndrome that causes accelerated lung function decline and death in the 20% of cases.
- Trial name
- CORSAI (NCT04628962)
- Testing
- Collection and Raman analysis of saliva for the database
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Resonance Raman Spectroscopy for Dietary Carotenoid Intake
Carotenoid Response to the Intake of Vegetables and Fruits
The purpose of this study is to validate the non-invasive tool, resonance Raman spectroscopy for assessing vegetable and fruit consumption.
- Trial name
- NCT01403844
- Testing
- Carotenoid Depletion, Carotenoid Repletion, Natural Repletion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Diabetic Foot Ulcer
Transcutaneous Raman Spectroscope (TRS) Analyses of Diabetic Foot Ulcers
The primary translational research objective of the study is to demonstrate feasibility of using the Transcutaneous Raman Spectroscopy technology in a point-of-care environment.
- Trial name
- NCT02202668
- Testing
- TRS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Covid19
The Salivary Raman COVID-19 Fingerprint
The outbreak of coronavirus disease 2019 (COVID-19), caused by infection of SARS-CoV-2, has rapidly spread to become a worldwide pandemic.
- Trial name
- NCT04583306
- Testing
- Raman analysis of saliva, characterization of the Raman database and building of the classification model
- Where
- 5 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Amyotrophic Lateral Sclerosis
Salivary Biomarker Discovery by Raman Spectroscopy in ALS (SalivALS)
BACKGROUND/RATIONALE: The paucity of biomarkers for the diagnosis and monitoring of patients affected by Amyotrophic Lateral Sclerosis (ALS) is one of the greatest concerns in ALS clinics and research.
- Trial name
- SalivALS (NCT04233099)
- Testing
- Raman analysis of saliva with data collection and analysis
- Where
- 2 sites in Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Prostate Cancer
Multicenter, Prospective Clinical Study of the Serum Raman Spectroscopy Intelligent System for the Diagnosis of Prostate Cancer
At present, the most commonly used clinical screening tool is based on prostate-specific antigen (PSA) examination. Because PSA is a tissue-specific rather than a tumor-specific marker, it has low specificity and sensitivity for…
- Trial name
- NCT05854940
- Testing
- Serum Raman spectroscopy intelligent diagnostic system
- Where
- China
- Volunteers
- 490 people
- Sponsor
- RenJi Hospital
Endometriosis, Endometrioma
Raman Spectroscopy and Endometriosis
We aimed to use Raman spectroscopy to detect differences between healthy controls and patients with surgically proven endometriosis.
- Trial name
- NCT04015297
- Testing
- raman analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Coronary Atherosclerosis of Native Coronary Artery
Cardiovascular Risk Stratification on the Basis of Surface Enhanced Raman Spectroscopy
In the modern population, mortality and disability from cardiovascular diseases is predominant and is realized as a major medical and social problem.
- Trial name
- CRUISERS (NCT06399328)
- Testing
- Surface Enhanced Raman Spectroscopy
- Where
- Russia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Samara State Medical University
Menopause
TRANSDERMAL HRT RELIEVING POSTMENOPAUSAL SYMPTOMS
There is a dilemma and a permanent debate about side effects on drugs administered orally. The first-pass metabolism is related with many side effects, since the metabolites of these compounds affect the course of human…
- Trial name
- THRT (NCT02033512)
- Testing
- Transdermal Hormone Replacement Therapy, Transdermal Nanoformulation, Transdermal formulation
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Potiguar