Clinical trials: Radiotherapy Side Effect
Cancer, Hepatocellular, Radiotherapy Side Effect
A Pilot Study For Patients Receiving Radiation Therapy for Liver Cancer
The purpose of this study is to evaluate the role of quantitative MR imaging and blood-based biomarkers to measure liver function in patients receiving radiation therapy for liver cancer or cancer that has spread to the liver.
- Trial name
- HepQuant (NCT06144827)
- Testing
- Multiparametric MRI scans, Multiparametric MRI scans + HepQuantShunt Test
- Sponsor
- Montefiore Medical Center
Brain Metastases, Radiotherapy Side Effect
Multicenter Retrospective Study on Patients Treated with Stereotactic Radiosurgery/Radiotherapy for Single Brain Lesions: Evaluation of Treatment Efficacy and Safety, Also Through Radiomic Analysis Methods.
The study design concerns all patients diagnosed witha singular brain metastasis who underwent stereotactic radiosurgery/radiotherapy between January 2010 and December 2022
- Trial name
- STEREOMIC (NCT06869460)
- Testing
- Stereotactic Body Radiotherapy/Radiosurgery
- Where
- 4 sites in Italy
- Volunteers
- 372 people
- Sponsor
- Gemelli Molise Hospital
Radiotherapy Side Effect, Xerostomia Due to Radiotherapy
Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy: a Multi-centric Cross-sectional Study
The study titled "Prevalence of Late Xerostomia and Hyposalivation with Associated Risk Factors in Survivors of Head and Neck Cancer After Radiotherapy" is a multi-centric cross-sectional study conducted in Egypt.
- Conditions
- Radiotherapy Side Effect, Xerostomia Due to Radiotherapy, Xerostomia Due to Radiotherapy (Disorder)
- Trial name
- NCT06851572
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Ain Shams University
Quality of Life (QOL), Head and Neck Cancer
Radiotherapy of Head and Neck Cancer With SIB
Title: Simultaneous Integrated Boost in Primary and Adjuvant Therapy of Head and Neck Tumors: Quality Control Registry Prospective Longitudinal Observational Study Short Title: Radiotherapy for Head and Neck Tumors with SIB…
- Conditions
- Quality of Life (QOL), Head and Neck Cancer, Radiotherapy Side Effect, Radiotherapy, Conformal (IMRT)
- Trial name
- NCT06831903
- Where
- Germany
- Volunteers
- 750 people
- Sponsor
- Wuerzburg University Hospital
Head and Neck Cancers, Head and Neck Cancers - Nasopharyngeal
Predictive Tools in Head and Neck Cancer Patients Undergoing Radiotherapy
The ITHACA study aims to improve the treatment of head and neck cancer by developing a predictive tool that helps doctors personalize care for each patient.
- Conditions
- Head and Neck Cancers, Head and Neck Cancers - Nasopharyngeal, Oral Cavity Cancer, Oropharyngeal Cancers
- Trial name
- ITHACA (NCT06806683)
- Testing
- intensity modulated radiotherapy
- Where
- Italy
- Volunteers
- 915 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Thrombopenia, Cervical Cancer
Herombopag for the Prevention of Radio-chemotherapy Induced Thrombocytopenia in Cervical Cancer
Exploring and evaluating the efficacy of herombopag in preventing thrombocytopenia due to radiotherapy for cervical cancer
- Conditions
- Thrombopenia, Cervical Cancer, Radiotherapy Side Effect, Chemotherapeutic Toxicity
- Trial name
- NCT06745219
- Testing
- herombopag
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Cancer Hospital & Institute
Esophageal Cancer, Radiotherapy
PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy
The PROTECT trial will test the hypothesis that proton (PT) -enabled radiation dose reductions to sensitive, normal tissues will result in lower rates of treatment-related pulmonary complications in esophageal cancer compared to…
- Conditions
- Esophageal Cancer, Radiotherapy, Side Effect, Proton Therapy
- Trial name
- PROTECT (NCT05055648)
- Testing
- Photon Radiotherapy, Proton Radiotherapy
- Where
- 15 sites in Belgium, Denmark and 6 more
- Volunteers
- 396 people
- Sponsor
- University of Aarhus
Head and Neck Neoplasms, Radiotherapy Side Effect
Nutrition and Inflammation in Patients With Head and Neck Cancer
An estimated 1500 people in Sweden will annually be diagnosed with head and neck cancer (HNC). Five year survival is approximately 69%. Long-term sequelae are common and in particular nutritional problems and fatigue.
- Conditions
- Head and Neck Neoplasms, Radiotherapy Side Effect, Inflammation, Metabolism
- Trial name
- NCT03343236
- Testing
- Radiotherapy
- Where
- Sweden
- Volunteers
- 522 people
- Sponsor
- Uppsala University
Head and Neck Cancers, Trismus
Exercise Therapy and Jaw-Mobilizing Device for Trismus in Head and Neck Cancer Patients
This study evaluates the effects of exercise therapy combined with a jaw-mobilizing device on enhancing quality of life in head and neck cancer patients undergoing radiotherapy.
- Conditions
- Head and Neck Cancers, Trismus, Radiotherapy Side Effects
- Trial name
- ET-JMD for Tri (NCT06719388)
- Testing
- combination of exercise therapy and a jaw-mobilizing device, exercise therapy only
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Taipei Medical University
Radiotherapy Side Effect, PROMs
Patient Experience Data in Radiation Oncology
The project is part of the overarching goal of improving patient-centric radiation oncology. This pilot project aims to develop an instrument that can be used to collect clinically relevant patient-reported outcome data on…
- Trial name
- PEDRO (NCT05224297)
- Testing
- external beam photon therapy
- Where
- Austria
- Volunteers
- 6,000 people
- Sponsor
- Medical University of Vienna
Breast Cancer, Radiotherapy Side Effect
Molecular Biomarkers of Response to Radiation Therapy in Breast Cancer
The purpose of this study is to identify potential genetic and other molecular biomarkers of response to radiation therapy in breast cancer that may help to personalize breast cancer radiation treatment in the future.
- Trial name
- NCT06648148
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- Institute of Oncology Ljubljana
Radiotherapy Side Effect, Pelvic Cancer
AI as an Aid for Weekly Symptom Intake in Radiotherapy
The study investigates the use of artificial intelligence (AI) and large language models (LLMs) to enhance the efficiency and accuracy of weekly treatment consultations (OTVs) in radiotherapy.
- Conditions
- Radiotherapy Side Effect, Pelvic Cancer, Patient
- Trial name
- NCT06525181
- Testing
- Generative Artificial Intelligence, Standard weekly symptom intake
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- jaide
Breast Cancer, Radiotherapy Side Effect
Super-Hypofractionated Partial Breast Irradiation
Partial breast irradiation is currently a hot topic in clinical research, but the appropriate population and appropriate irradiation The technology and dose fractionation mode are still inconclusive.
- Trial name
- NCT06615466
- Testing
- Partial Breast Irradiation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Anal Cancer, Radiotherapy Side Effect
Bone-sparing Chemoradiotherapy for Anal Cancer - DACG-II
This study proposal includes a prospective clinical trial of bone sparing treatment planning in anal cancer patients. the trial aim to lower the risk of bone damage, while adhering with the constrains to the bowel, bladder and…
- Trial name
- DACG-II (NCT05385250)
- Testing
- Bone sparring radiotherapy
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Karen-Lise Garm Spindler
Brain Metastases, Radiotherapy Side Effect
GM1 Prophylaxis for WBRT Related Cognitive Dysfunction
To evaluate the efficacy and safety of GM1 for preventing cognitive impairment related to whole brain radiotherapy in breast cancer patients with brain metastases.
- Conditions
- Brain Metastases, Radiotherapy Side Effect, Cognitive Impairment, Gangliosidosis, GM1
- Trial name
- GLORY (NCT04395339)
- Testing
- Monosialotetrahexosyl ganglioside (GM1), Control
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sun Yat-sen University
Head and Neck Cancer, Chronic Periodontitis
Estimation of (suPAR) in Chronic Periodontitis With Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy Side Effect
- Trial name
- HNCs (NCT06529588)
- Testing
- Radiation
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Radiotherapy Side Effect, Mucositis
Adjunctive Treatments for the Prevention of Radiotherapy-Induced Mucositis
Radiation therapy (RT) is used in at least 50% of cancer patients and is critical in treating and palliating tumor-related symptoms.
- Trial name
- NCT06117904
- Testing
- MEBO ointment, Symptomatic treatment only
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Radiodermatitis; Acute, Radiotherapy Side Effect
The Use of Photobiomodulation in the Management of Radiodermatitis in Head and Neck Cancer Patients
It is estimated that there will be 670,000 new cases of cancer worldwide in 2020-2022 and it is known that the most commonly instituted treatments in cancer are chemotherapy, radiotherapy and surgery.
- Conditions
- Radiodermatitis; Acute, Radiotherapy Side Effect, Head and Neck Cancer
- Trial name
- NCT05557825
- Testing
- Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- University of Nove de Julho
Cervical Cancer, Proton Therapy
Proton Therapy for Locally Advanced Cervical Cancer
The purpose of this protocol is to determine toxicity and efficacy of proton therapy in combination with standard concomitant platinum-based chemotherapy and standard image-guided adaptive brachytherapy (IGABT) in patients with…
- Conditions
- Cervical Cancer, Proton Therapy, Radiotherapy Side Effect
- Trial name
- NCT06462378
- Testing
- Proton therapy
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- University of Aarhus
Thrombocytopenia, Radiotherapy Side Effect
Hetrombopag for the Thrombocytopenia Induced by Concurrent Chemoradiotherapy
Thrombocytopenia represents one of the main toxicities of concurrent chemoradiotherapy, which may necessitate chemotherapy dose reductions, dose delays, or discontinuation, and even compromise survival.
- Trial name
- NCT06433830
- Testing
- Hetrombopag Olamine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital