Clinical trials: Radiofrequency Catheter Ablation, open to volunteers
Atrial Fibrillation (AF), Atrial Fibrillation Catheter Ablation
The COMBINE-AF Trial
The goal of this clinical trial is to test if a more complete ablation procedure works better than the standard procedure for people with long-lasting persistent atrial fibrillation (AF).
- Trial name
- COMBINE-AF (NCT07633509)
- Testing
- Linear ablation of mitral isthmus and tricuspid isthmus, Ethanol, Radiofrequency Ablation Catheter
- Where
- 3 sites in China
- Volunteers
- 430 people
- Sponsor
- Yunlong Wang
Atrial Fibrillation
PROSPective Evaluation of Outcome After CatheTer Ablation in Atrial Fibrillation
Atrial fibrillation ablation is the most common intervention performed worldwide. Up to 20 to 45% of patients show recurrence of AF within 12 month after catheter ablation, however its determinant are incompletely understood.
- Trial name
- PROSPECT-AF (NCT05009797)
- Testing
- atrial fibrillation catheter ablation
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Lille
Atrial Fibrillation, Cardiomyopathy, Hypertrophic
Concomitant Hybrid Versus Catheter Ablation for Atrial Fibrillation With Hypertrophic Cardiomyopathy
The goal of this clinical trial is to compare the rhythm control effect in hypertrophic non-obstructive patients with non-paroxysmal atrial fibrillation by either concomitant catheter endocardial and thoracoscopic epicardial…
- Conditions
- Atrial Fibrillation, Cardiomyopathy, Hypertrophic, Radiofrequency Ablation
- Trial name
- NCT05610215
- Testing
- hybrid ablation, catheter ablation
- Where
- China
- Volunteers
- 66 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cholangiocarcinoma, Klatskin Tumor
Endoscopic Radiofrequency Ablation for Unresectable Cholangiocarcinoma
The goal of this clinical trial is to learn about radiofrequency ablation in patients with unresectable bile duct cancer who receive systemic chemotherapy and bile duct stenting.
- Conditions
- Cholangiocarcinoma, Klatskin Tumor, Bile Duct Cancer, Liver Cancer
- Trial name
- ACTICCA-2 (NCT06175845)
- Testing
- Intraductal biliary radiofrequency ablation
- Where
- 9 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Atrial Fibrillation
Multicenter Registry of Atrial Fibrillation Ablation With Radiofrequency Balloon Catheter
All consecutive patients with paroxysmal or persistent atrial fibrillation undergoing pulmonary vein isolation with the radiofrequency balloon catheter (RFB) "Heliostar" (Biosense Webster) will be included in a multicenter…
- Trial name
- COLLABORATE (NCT06333327)
- Testing
- Pulmonary vein isolation with the multielectrode radiofrequency balloon catheter
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Universitair Ziekenhuis Brussel
Atrial Fibrillation (AF), Stroke
Comparative Evaluation of the Efficacy and Safety of High-Power Short-Duration Radiofrequency Ablation and Standard Low-Power Ablation in Catheter Treatment of Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and represents one of the leading causes of cardiovascular morbidity and mortality.
- Conditions
- Atrial Fibrillation (AF), Stroke, Acute Cerebrovascular Accident, Atrial Fibrillation Recurrent
- Trial name
- NCT07728539
- Testing
- Technique of radiofrequency ablation using very high-power short-duration ablation parameters, Technique of radiofrequency ablation using low-power settings
- Where
- Russia
- Volunteers
- 196 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Varicose Veins of Lower Limb, Venous Insufficiency of Leg
Clinical Outcomes, Safety, and Cost-Effectiveness Analysis of Two Catheters (Xianrui Da and Medtronic) in Radiofrequency Ablation for Varicose Veins
This study aims to systematically compare the clinical efficacy (venous closure rate and symptom relief rate), safety (perioperative and postoperative complications), and cost-effectiveness (direct medical costs) of domestic…
- Conditions
- Varicose Veins of Lower Limb, Venous Insufficiency of Leg, Vascular Disease，Peripheral
- Trial name
- NCT07046286
- Testing
- Compare the two brands of radiofrequency ablation catheters for the treatment of lower limb varicose veins.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Atrial Fibrillation, Catheter Ablation
Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation
Atrial fibrillation (AF) is a common heart rhythm disorder affecting over a million people in North America and is associated with serious complications including stroke, heart failure, reduced quality of life, and premature…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Radiofrequency Catheter Ablation
- Trial name
- AWARE-2 (NCT04823299)
- Testing
- PVI-ONLY, CONTROL ARM, PVI-PLUS ARM, INTERVENTIONAL ARM
- Where
- 2 sites in Canada
- Volunteers
- 556 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation (AF)
Extended Ablation Versus Pulmonary Vein Isolation to Treat Persistent Atrial Fibrillation
The aim is to determine the effect of extended ablation (pre-specified linear PF/RF lesion set) in addition to PVI in symptomatic persistent AF patients on AF/AT/AFL recurrence.
- Trial name
- EXTEND-PVI (NCT07424326)
- Testing
- PVI-plus, PVI-only
- Where
- 4 sites in Czechia
- Volunteers
- 450 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation, HFpEF - Heart Failure With Preserved Ejection Fraction
Catheter Ablation in Atrial Fibrillation Patients With HFpEF (STABLE-SR IV Trial)
To investigate whether RFCA is superior to AADs in AF patients with HFpEF on the basis of optimized anti-heart-failure drug therapy regarding their longterm clinical outcomes.
- Trial name
- NCT06125925
- Testing
- Radiofrequency catheter ablation (RFCA), Medical Therapy
- Where
- China
- Volunteers
- 436 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Catheter Ablation, Radiofrequency
Early Ambulation Safety Evaluation, Ultrasound-guided Percutaneous Venous Closure
The purpose of this study is to evaluate whether patients can safely walk sooner after catheter-based heart procedures when the VASCADE MVP or VASCADE MVP XL vascular closure device is used.
- Trial name
- NCT07910227
- Testing
- VASCADE MVP and MVP XL
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Atrial Fibrillation Recurrent
Pulsed Field Ablation Versus Conventional Radiofrequency Catheter Ablation for Repeat PVI in Patients With Paroxysmal AF
Various methods exist for performing pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF), including thermal ablation and pulse-field ablation (PFA).
- Trial name
- REPEAT-AF (NCT06199180)
- Testing
- pulmonary vein isolation with RFA, pulmonary vein isolation with PFA
- Where
- Netherlands
- Volunteers
- 154 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation (AF), Persistent Atrial Fibrillation
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
Conquer-AF is a prospective, multi-center, interventional, non-randomized clinical study that will enroll up to 400 subjects at up to 30 sites across the United States, Europe, and Australia.
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- Conquer-AF (NCT07298473)
- Testing
- Sphere-9 Catheter Ablation
- Where
- 30 sites in United States, Australia and 4 more
- Volunteers
- 400 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Ventricular Tachycardia (VT), Ischemic Cardiomyopathy
MRI-guided Ventricular Tachycardia Ablation in Patients With Structural Heart Disease
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder that frequently occurs in patients with structural heart disease, such as ischemic or non-ischemic cardiomyopathy.
- Conditions
- Ventricular Tachycardia (VT), Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- MAGNET-VT (NCT07896980)
- Testing
- LGE-MRI-integrated EAM-guided catheter ablation, Conventional EAM-guided catheter ablation
- Where
- China
- Volunteers
- 526 people
- Sponsor
- China National Center for Cardiovascular Diseases
Persistent Atrial Fibrillation, Radiofrequency Catheter Ablation
Pulsed Field Ablation Versus Radiofrequency Ablation for Persistent Atrial Fibrillation
This clinical trial aims to compare the efficacy and safety of pulsed field ablation and radiofrequency ablation to treat persistent atrial fibrillation in adults.
- Conditions
- Persistent Atrial Fibrillation, Radiofrequency Catheter Ablation, Pulsed Field Ablation
- Trial name
- PRAISE (NCT06791629)
- Testing
- Pulsed Field Ablation, Radiofrequency Ablation
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Beijing Anzhen Hospital
Resistant Hypertension
The RESPLASH Study
To assess the safety and effectiveness of renal artery denervation with subsequent splanchnic nerves denervation via catheter-based radiofrequency ablation in improving blood pressure and glycemic control in patients with…
- Trial name
- NCT06880562
- Testing
- Splanchnic Nerve Denervation, Renal Denervation Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tulane University
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Pulsed Field Ablation Outcomes With Efficacy and Randomization in Atrial Fibrillation (POWER-AF)
Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. As of 2019, there were approximately 59.7 million patients with AF worldwide, including atrial flutter (AF).
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Atrial Fibrillation Recurrent, Pulsed Field Ablation
- Trial name
- POWER-AF (NCT07601763)
- Testing
- Pulsed field ablation, Radiofrequency ablation alone, Pulsed field ablation system
- Where
- China
- Volunteers
- 1,574 people
- Sponsor
- China National Center for Cardiovascular Diseases
Persistent Atrial Fibrillation
Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation
This prospective, randomized, single-center study will compare sevoflurane inhalational anesthesia with propofol intravenous anesthesia in patients undergoing intracardiac echocardiography-guided radiofrequency catheter ablation…
- Trial name
- NCT07877116
- Testing
- Sevoflurane, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Hüseyin Ulaş Pinar
Atrial Fibrillation (AF), Ablation Techniques
Electroporation vs. Radiofrequency Ablation Guided by 3D Imaging in Repeat Procedures for Atrial Fibrillation
This is a prospective, randomized clinical trial evaluating the efficacy and safety of two techniques for repeat catheter ablation in patients with recurrent atrial fibrillation (AF): thermal energy ablation (radiofrequency) and…
- Conditions
- Atrial Fibrillation (AF), Ablation Techniques, Radiofrequency Catheter Ablation, Pulsed Field Ablation
- Trial name
- ERA-rePVI (NCT07141745)
- Testing
- Pulsed field ablation of reccurent atrial arrythmia, Radiofrequency ablation of reccurent atrial arrythmia (standard of care)
- Where
- Poland
- Volunteers
- 250 people
- Sponsor
- Wroclaw Medical University
Atrial Fibrillation (AF)
Deep Sedation vs. General Anesthesia for Pulsed Field Ablation in Atrial Fibrillation
1. Research Title: A Study on the Safety and Efficacy of Deep Sedation With Dexmedetomidine Combined With Remimazolam and Remifentanil Versus General Anaesthesia for Radiofrequency Ablation of Atrial Fibrillation 2.
- Trial name
- SAFE-PFA (NCT07621432)
- Testing
- Standardized Deep Sedation Protocol, Standard General Anesthesia
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Nanchang University