Clinical trials: Radical Cystectomy
Bladder Cancer
Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery
The current usage of antibiotic prophylaxis (AP) in radical cystectomy (RC) is aimed to reducing the incidence of surgical site infections and incidence of unnecessary prescribing of antibiotics.
- Trial name
- MACS (NCT05392634)
- Testing
- Meropenem 1000 mg, Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg
- Where
- Russia
- Volunteers
- 98 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Bladder Cancer
Comparison of the Application of Robot-assisted Laparoscopic Pathways in Radical Cystectomy
Traditional radical cystectomy (RC) is performed transabdominal. However, it often has high postoperative complications. There have been studies on extraperitoneal approach to reduce postoperative complications.
- Trial name
- NCT06253091
- Testing
- robit-assist extraperitoneal laparoscopic radical cystectomy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Bladder Cancer
MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy
Cystectomy is the chosen treatment of bladder cancer in 400 cases every year in DK. In replacement of the removed bladder, a urinary diversion is constructed using 15cm of terminal ilium (Ad Modum Bricker).
- Trial name
- MOSAIC (NCT04391790)
- Testing
- Cystectomy and modified urinary conduit, Cystectomy and standard urinary conduit ad modum Bricker
- Where
- 5 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Jørgen Bjerggaard Jensen
Fluid Retention Tissue
Comparison of Liberal and Restrictive Fluid Management on the Endothelial Glycocalyx in Radical Cystectomy
The aim of this study is to compare the effect of the liberal and restrictive fluid treatments which are routinely performed in major urological surgeries in the perioperative period on ANP release and the endothelial glycocalyx…
- Trial name
- NCT04780490
- Testing
- liberal fluid management, restrictive fluid management
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Istanbul University
Bladder Cancer, Bladder
A Window of Opportunity Phase I Study of UGN-201 in Patients With Bladder Cancer Undergoing Radical Cystectomy Protocol #: 2021-0630
he primary objective is to characterize the safety profile of UGN-201 in patients with urothelial carcinoma undergoing radical cystectomy.
- Trial name
- NCT05055050
- Testing
- UGN-201
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Blood Loss, Surgical, Postoperative Hemorrhage
Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy
The purpose of this study is to assess if aprotinin (BAYA0128), given intravenously during your surgery, is safe and can help reduce the need for a blood transfusion during bladder surgery.
- Trial name
- NCT00306150
- Testing
- Trasylol (Aprotinin, BAYA0128)
- Where
- 37 sites in United States, Belgium and 5 more
- Volunteers
- 57 people
- Sponsor
- Bayer
Bladder Cancer, Metastatic Bladder Cancer
A Window of Opportunity Trial: Avelumab in Non-metastatic Muscle Invasive Bladder Cancer
This is a pilot study of avelumab in patients with non-metastatic, muscle invasive bladder cancer who are eligible for radical cystectomy (RC), but are ineligible for cisplatin based neoadjuvant therapy.
- Conditions
- Bladder Cancer, Metastatic Bladder Cancer, Invasive Bladder Cancer
- Trial name
- NCT03498196
- Testing
- Avelumab
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Radical Cystectomy
A Study to Determine if Mesh Placement During Bladder Surgery Can Reduce the Chances of Developing a Hernia
The purpose of this study is to compare any good and bad effects of using Ultrapro mesh along with the usual bladder removal surgery, versus having the usual bladder removal surgery without the use of the mesh.
- Trial name
- NCT02908061
- Testing
- Surgery Radical Cystectomy, Ultrapro mesh
- Where
- 7 sites in United States
- Volunteers
- 178 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Anesthesiology Management
Recovery From Anesthesia After Robotic Assisted Radical Cystectomy
Robot-assisted radical cystectomy (RARC) requires specific surgical conditions: steep Trendelenburg position, prolonged pneumoperitoneum, effective neuromuscular block until the final stages of surgery.
- Trial name
- NCT03144453
- Testing
- Sugammadex Injectable Product, Neostigmine, Atropine
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Regina Elena Cancer Institute
Stage III Bladder Cancer, Stage IV Bladder Cancer
Comparison of Immediate and Delayed Adjuvant Chemotherapy in Treating Patients Who Have Undergone a Radical Cystectomy for Stage III or Stage IV Transitional Cell Carcinoma of the Bladder Urothelium
Randomized phase III trial to compare the effectiveness of immediate adjuvant chemotherapy with that of adjuvant chemotherapy given when the cancer returns in treating patients who have undergone a radical cystectomy for stage…
- Conditions
- Stage III Bladder Cancer, Stage IV Bladder Cancer, Transitional Cell Carcinoma of the Bladder
- Trial name
- NCT00028756
- Testing
- doxorubicin hydrochloride, gemcitabine hydrochloride, vinblastine sulfate
- Volunteers
- 285 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Bladder Cancer
PET/MRI and Biomarkers in Bladder Cancer
Muscle invasive bladder cancer is an aggressive malignancy. Currently the investigators lack accurate imaging technologies in clinical staging and estimation of response to neoadjuvant chemotherapy as well as prognostic…
- Trial name
- ACEBIB (NCT01918592)
- Testing
- MRI/acetate-PET imaging
- Where
- 3 sites in Finland
- Volunteers
- 25 people
- Sponsor
- Turku University Hospital
Radical Cystectomy
Renal Protection of Intravenous Dexmedetomidine During Radical Cystectomy
Acute kidney injury and chronic kidney disease usually associated with radical cystectomy operation which is the treatment of choice for invasive urinary bladders tumor.
- Trial name
- NCT03265470
- Testing
- Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Urothelial Carcinoma of the Bladder, Muscle Invasive Bladder Cancer (MIBC)
Perioperative Systemic Therapies in Muscle-Invasive Bladder Cancer (GUARDIANS)
This is a multicenter, non-interventional, prospective and retrospective observational patient registry study of adults with muscle-invasive bladder cancer receiving perioperative systemic therapy as part of routine clinical…
- Trial name
- GUARDIANS (NCT07855926)
- Testing
- Perioperative Systemic Therapy Registry
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- LMU Klinikum
Urothelial Carcinoma
Sacituzumab Govitecan, Preceding Radical Cystectomy, in Treating Patients With Muscle-invasive Bladder Cancer
SURE-01 is a neoadjuvant phase 2, open-label, non-randomized, singlecohort study in patients with urothelial carcinoma of the bladder. Patients will be consecutively enrolled and treated.
- Trial name
- NCT05226117
- Testing
- Sacituzumab govitecan
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS San Raffaele
Urinary Bladder Neoplasms, Woman
Urinary Continence of Female POPRC and OIN
To compare the urinary continence rate and long-term oncological outcomes of pelvic-organ preserving radical cystectomy (POPRC) with orthotopic ileal neobladder (OIN) versus standard radical cystectomy(SRC) with OIN.
- Conditions
- Urinary Bladder Neoplasms, Woman, Sexual Dysfunction, Physiological, Treatment Outcome
- Trial name
- NCT05325216
- Testing
- POPRC+OIN, SRC+OIN
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Urinary Bladder Neoplasms
Virtual Histology of the Bladder Wall for Bladder Cancer Staging
This is a phase Ib study of the safety and performance of a novel intravesical contrast-enhanced Magnetic Resonance Imaging protocol for determination of bladder cancer stage prior to transurethral resection of bladder tumor (21…
- Trial name
- NCT04369560
- Testing
- Magnetic Resonance Imaging, Gadobutrol intravesical administration (4mM), Ferumoxytol intravesical administration (5 mM)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Jodi Maranchie
Bladder Cancer, Low Testosterone Levels
Perioperative Hypogonadism in Men Undergoing Radical Cystoprostatectomy for Bladder Cancer
The purpose of this study is to examine the relationship between testosterone level changes around the time of radical cystectomy.
- Trial name
- NCT03063125
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
Bladder Cancer
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
The purpose of this study is to assess the antitumor efficacy and safety of perioperative enfortumab vedotin (EV) plus pembrolizumab and radical cystectomy (RC) + pelvic lymph node dissection (PLND) compared with the current…
- Trial name
- KEYNOTE-B15 (NCT04700124)
- Testing
- Pembrolizumab, Enfortumab vedotin (EV), RC + PLND
- Where
- 188 sites in United States, Argentina and 27 more
- Volunteers
- 808 people
- Sponsor
- Merck Sharp & Dohme LLC
Carcinoma of Urinary Bladder, Invasive
Safety and Tolerability Study Which Evaluate Intravesical Instillation With Mitomycin C Mixed With TC-3 Drug Retaining Hydrogel Device In Patients With Muscle Invasive Bladder Cancer
The purpose of this study is to evaluate the safety of intravesical instillation of TC-3 Hydrogel disposable device for retention of mitomycin C chemotherapeutic drug in the urinary bladder.
- Trial name
- NCT01648010
- Testing
- TC-3 gel, TC-3 gel mixed with Mitomycin C (MMC)
- Where
- 3 sites in Israel
- Volunteers
- 7 people
- Sponsor
- UroGen Pharma Ltd.
Bladder Cancer, Postoperative Pain
Comparing Rectus Sheath Catheter to Epidural Post Cystectomy
This is a prospective randomised controlled trial that will compare the outcomes of rectus sheath catheters to epidurals in patients who have undergone a cystectomy, via a lower midline abdominal incision for bladder cancer.
- Trial name
- NCT02572804
- Testing
- Epidural, Rectus Sheath Catheters
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Vancouver Coastal Health