Clinical trials: Radiation Therapy
Prostate Cancer (Adenocarcinoma), Prostate Brachytherapy
PRO-BOOST-LC: Whole-Gland Boost Strategies Versus SBRT Monotherapy in PSMA-Staged Localized and Locally Advanced Prostate Cancer
PRO-BOOST-LC is a prospective, multicenter, randomized phase II/III clinical trial for men with localized or locally advanced prostate cancer without lymph node or distant metastases, confirmed using prostate-specific membrane…
- Conditions
- Prostate Cancer (Adenocarcinoma), Prostate Brachytherapy, Stereotactic Body Radiation Therapy (SBRT), Dose Escalation: Solid Tumors
- Trial name
- PRO-BOOST-LC (NCT07426055)
- Testing
- Stereotactic Body Radiotherapy (SBRT) Monotherapy, External Beam Radiotherapy (EBRT) Backbone, High-Dose-Rate Brachytherapy Boost
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Prostate Cancer, Brachytherapy
PRO-BOOST-N: Prostate-First Versus Combined Prostate and Nodal Dose Escalation in PSMA PET-Staged Node-Positive Prostate Cancer
PRO-BOOST-N is a prospective, multicenter, randomized phase II/III clinical trial for patients with prostate cancer and pelvic lymph node involvement (cN1M0) confirmed by PSMA PET/CT, without distant metastatic disease.
- Conditions
- Prostate Cancer, Brachytherapy, Stereotactic Body Radiation Therapy (SBRT), Dose Escalation: Solid Tumors
- Trial name
- PRO-BOOST-N (NCT07426094)
- Testing
- Ultrahypofractionated Whole-Pelvis Radiotherapy, SBRT-Based Prostate Radiotherapy (No Boost), Ablative Prostate Boost
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Metastatic Malignant Neoplasm in the Brain, Radiation Therapy Recipient
nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex
This trial studies how well nTMS works in planning for stereotactic radiosurgery in patients with brain metastases in the motor cortex.
- Trial name
- NCT04062305
- Testing
- Hand Function Test, Navigated Transcranial Magnetic Stimulation, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Radiation Therapy
Capturing Food Intake in Patients Undergoing Radiation Therapy for Cancer
The purpose of this study is to determine the feasibility of capturing daily dietary intake of patients undergoing radiation therapy using a mobile food record.
- Conditions
- Cancer, Radiation Therapy, Dietary Intake
- Trial name
- NCT07682714
- Testing
- Mobile food record using myCircadian Clock app
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Metastatic Sarcoma, Radiation Therapy Patient
Targeted Oligometastatic Radiation in Pediatric and Young Adult Patients With Soft Tissue and Bone Sarcoma
This study is designed for children, adolescents and young adults undergoing radiation therapy for metastatic sarcoma. The aim of the study is to investigate if the investigators can improve the overall survival of these patients…
- Conditions
- Metastatic Sarcoma, Radiation Therapy Patient, Ewing Sarcoma, Rhabdomyosarcoma
- Trial name
- TARGET-RT (NCT06796543)
- Testing
- Consolidative radiation therapy (cRT)
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Radiation Therapy, Virtual Reality
Effectiveness of Virtual Reality (VR) in the Management of Anxiety for Patients Undergoing Radiotherapy
The purpose of this study is to evaluate the use and functionality of virtual reality (VR) during radiation therapy treatments for patients with prostate, breast, lung, or head and neck cancer.
- Trial name
- RELAX (NCT07324577)
- Testing
- standard of care, Virtual Reality Intervention, Radiation Therapist Survey
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer, Radiation Therapy Patient
A Pilot Study to Evaluate the Effectiveness of Focused Massage on Pain, Mobility, and Quality of Life During Radiation Treatment for Patients With Breast Cancer
The goal of this interventional study is to to evaluate the effectiveness and acceptability of a focused upper body massage when offered after radiation treatments to participants diagnosed with breast cancer.
- Trial name
- NCT07447700
- Testing
- upper body massage
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Brain Metastasis, Radiation Therapy
18F-FLUC PET/MR in Patients With Brain Mets
The goal of this clinical trial is to use new imaging methods to help in finding out whether the imaging shows that there is a tumor in people with a brain metastasis.
- Conditions
- Brain Metastasis, Radiation Therapy, Immunotherapy, Active
- Trial name
- NCT06159335
- Testing
- F-Fluciclovine radiotracer
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Radiation Therapy
EVALUATION OF THE BENEFITS OF SOPHROLOGY FOR PATIENTS UNDERGOING RADIOTHERAPY
Anxiety is a common symptom among patients undergoing radiation therapy, stemming from their cancer diagnosis, anticipation of side effects, and the specific challenges associated with the treatment sessions.
- Trial name
- SORA-RT (NCT07652060)
- Testing
- Sophrology
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Clinique Pasteur Lanroze
Liver Metastases, Stereotactic Body Radiation Therapy
OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases
The purpose of this trial is to identify a safe maximum tolerated dose level for MRI-guided Stereotactic Body Radiation Therapy (SBRT) treatment of bowel and liver metastases, respectively.
- Conditions
- Liver Metastases, Stereotactic Body Radiation Therapy, MRI-guided Treatment
- Trial name
- NCT04020276
- Testing
- SBRT
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Radiation Therapy
Study to Evaluate the Safety of Colchicine
Currently, there are no approved medications for the prevention and treatment of radiation-induced dermatitis, or skin discoloration/burning due to radiation therapy, because there is little evidence to guide treatment.
- Trial name
- NCT05335148
- Testing
- oral colchicine(0.6 mg) once a day
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rutgers, The State University of New Jersey
Cancer, Radiation Therapy
Virtual Reality Education for Radiation Therapy Patients
Radiation therapy is an important treatment for cancer, but patients receiving radiation therapy for the first time may experience anxiety because they are unfamiliar with the treatment process, equipment, and possible side…
- Conditions
- Cancer, Radiation Therapy, Patient Education
- Trial name
- NCT07598851
- Testing
- Conventional Nurse-Led Patient Education, 360-Degree Virtual Reality Patient Education
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- Asia University
Head and Neck Neoplasms, Radiation Therapy Complication
Collection of Head Images During Radiotherapy
The primary objective of this observational study is to quantify the translation, rotation, and deformation of patient head positions of head and neck cancer patients over the course of a radiation therapy treatment for head and…
- Trial name
- CHIRP (NCT05218824)
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- University of Sydney
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
3D Specimen Maps for RT Planning
The primary objective of this study is to measure the impact of patient-specific 3D specimen maps on adjuvant radiation treatment volumes and doses to critical organs.
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Radiation Therapy
- Trial name
- NCT05743569
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Vanderbilt University Medical Center
Decision Making, Shared, Stereotactic Body Radiation Therapy
Shared Decision Making on Radiation Dose for Lung Malignancies
A Patient Decision Aid (PtDA) is developed during a workshop in close collaboration with selected patients. The PtDA is subsequently used in the consultation between patient and physician to facilitate their shared decision on…
- Conditions
- Decision Making, Shared, Stereotactic Body Radiation Therapy, Lung Cancer, Non-small Cell, Radiation Toxicity
- Trial name
- NCT04940936
- Testing
- A Patient Decision Aid
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Vejle Hospital
Rectal Cancer, Total Neoadjuvant Treatment
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
This study hypothesizes that approximately 50% of rectal cancer patients can preserve their rectum using a watch-and-wait strategy if they achieve a complete or near-complete clinical response to total neoadjuvant therapy (TNT).
- Conditions
- Rectal Cancer, Total Neoadjuvant Treatment, Neoadjuvant Therapy, Radiotherapy
- Trial name
- NCT06758830
- Testing
- Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Non Small Cell Lung Cancer, Radiation Therapy Patient
Concomitant Use of Radiotherapy and Integrated Exercise - Lung Cancer
Study objective and procedures The objective of CURIE-LC is to evaluate the feasibility (i.e., whether it is possible and safe) of carrying out a comprehensive exercise program during combined radiotherapy and chemotherapy in…
- Conditions
- Non Small Cell Lung Cancer, Radiation Therapy Patient, Stage II/III
- Trial name
- NCT07489391
- Testing
- Multimodal exercise
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- University of Deusto
Cervical Cancer, Radiation Therapy Complication
Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies
This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation…
- Conditions
- Cervical Cancer, Radiation Therapy Complication, Pelvic Floor Disorders
- Trial name
- NCT07447895
- Testing
- Pelvic floor physical therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Cincinnati
Radiation Therapy, Metastatic Renal Cancer
CAIX PET/ CT Guided Radiation Therapy in CcRCC.
This is a prospective, single-arm study in adults with recurrent or metastatic clear cell renal cell carcinoma (ccRCC). Participants will receive standard systemic therapy (targeted therapy plus anti-PD-1 immunotherapy) and…
- Conditions
- Radiation Therapy, Metastatic Renal Cancer, Recurrent Renal Cell Cancer
- Trial name
- COSTAR-002 (NCT07540260)
- Testing
- PETCT-guided radiation therapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
Treatment With Proton Beam Radiation Therapy
Proton Therapy Patient Registry
The purpose of this study is to establish a database (or "registry") of patients treated with proton beam therapy at the University Hospitals (UH) Proton Therapy Center.
- Trial name
- NCT02986048
- Testing
- Proton Beam Therapy
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- Case Comprehensive Cancer Center