Clinical trials: Radiation Pneumonitis
Breast Cancer, Radiation Pneumonia
Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer
This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients.
- Conditions
- Breast Cancer, Radiation Pneumonia, COVID-19
- Trial name
- NCT07188116
- Testing
- COVID-19
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhejiang Hospital
Lung Cancer (NSCLC), Lung Cancer (SCLC)
Multi-Omics Prediction of Radiation Lung Injury in Immunotherapy-Treated Lung Cancer Patients
This prospective study aims to develop a multi-omics-based predictive model for radiation pneumonitis in lung cancer patients receiving sequential immunotherapy and thoracic radiotherapy.
- Trial name
- NCT07742800
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 160 people
- Sponsor
- HAN GUANG
Lung Cancer, Radiation Pneumonitis
Mitigation of Radiation Pneumonitis and Fibrosis
This project will test the effect of enalapril to mitigate the lung damage that can occur as a side effect of radiation therapy for lung cancer or other intrathoracic cancers.
- Trial name
- NCT01754909
- Testing
- Enalapril
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Non-small-cell Lung Cancer, Radiation Pneumonitis
Role of SPECT in Radiotherapy of Lung Cancer and Toxicity Evaluation
Overall objective of the study is to compare the use of SPECT in radiotherapy treatment planning with standard CT-based radiotherapy for stage I-III non-small-cell lung cancer patients
- Trial name
- NCT01745484
- Testing
- SPECT-based treatment plan
- Where
- Denmark
- Volunteers
- 71 people
- Sponsor
- University of Aarhus
Lung Non-Squamous Non-Small Cell Carcinoma, Radiation-Induced Pneumonitis
Nintedanib Compared With Placebo in Treating Against Radiation-Induced Pneumonitis in Patients With Non-small Cell Lung Cancer That Cannot Be Removed by Surgery and Are Undergoing Chemoradiation Therapy
This trial studies the side effects and how well nintedanib works compared to a placebo in treating against radiation-induced pneumonitis (inflammation of the lungs) in patients with non-small cell lung cancer that cannot be…
- Conditions
- Lung Non-Squamous Non-Small Cell Carcinoma, Radiation-Induced Pneumonitis, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Non-Small Cell Carcinoma AJCC v7
- Trial name
- NCT02452463
- Testing
- Durvalumab, Nintedanib, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Roswell Park Cancer Institute
Radiation Pneumonitis, Endostatin
Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis
To verify the efficacy and safety of endostatin in the treatment of SRILI（symptomatic radiation-induced lung injury） and fibrosis.
- Trial name
- NCT03796364
- Testing
- Endostar, standard SRILI treatment
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xinqiao Hospital of Chongqing
COVID-19 Pneumonitis
Low Dose Whole Lung Radiotherapy for Older Patients With COVID-19 Pneumonitis
Low dose whole lung radiotherapy may improve survival of older patients with COVID-19 pneumonitis
- Trial name
- NCT04493294
- Testing
- Low dose whole lung radiotherapy for older patients with COVID-19 pneumonitis
- Volunteers
- 500 people
- Sponsor
- International Geriatric Radiotherapy Group
Radiation Toxicity
Oligo-Fucoidan Decrease Lung Radiation Damage
Fucoidan is FDA approved and in common use for treatment of angina. These studies will advance that work to human use. Successful mitigation of lung radiation damage and heart toxicity will improve the quality of life in veterans…
- Trial name
- FIRILI (NCT05616507)
- Testing
- fucoidan
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Non-Small Cell Lung Cancer, Radiation Induced Lung Injury (RILI)
Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation
Currently, the standard of care treatment for newly diagnosed, inoperable stage III non-small cell lung cancer is radiotherapy (RT) with concurrent chemotherapy, followed by immune checkpoint inhibitors (ICI).
- Trial name
- P4-PACIFIC (NCT06634056)
- Testing
- Pentoxifylline, α-Tocopherol
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Radiation Pneumonitis
Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients
This randomized clinical study aims to assess whether prophylactic treatment with inhaled steroids in patients with locally advanced or concomitantly treated non-small cell lung carcinoma who are candidates for combination…
- Trial name
- NCT03803787
- Testing
- Inhaled budesonide
- Where
- 2 sites in Mexico
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Lung Cancer
Ventilation Imaging to Improve the Quality of Life for Patients With Lung Cancer Treated With Radiation Therapy
This research project is testing a new treatment planning method for patients with lung cancer who will be treated with radiation therapy. This new method is called Computed Tomography (CT) ventilation imaging.
- Trial name
- VITaL (NCT06127654)
- Testing
- Healthy lung sparing treatment plan
- Where
- Australia
- Volunteers
- 165 people
- Sponsor
- University of Sydney
Lung Cancer
Pneumonitis in Older Lung Cancer Patients After Radiotherapy
The main goal of this trial is to establish the performance characteristics and to develop a decision-algorithm of a new symptom-based scoring system with respect to the identification of elderly lung cancer patients developing…
- Trial name
- POLCAR (NCT06480734)
- Testing
- symptom-based scoring system (symptom-questionnaire, paper version)
- Where
- 5 sites in Denmark, Germany
- Volunteers
- 62 people
- Sponsor
- University Hospital Schleswig-Holstein
Lung Cancer
Moderate Hypofractionated Radiotherapy for Lung Cancer
The purpose of this study is to evaluate the incidences of Grade III and above radiation-reduced esophagitis and radiation-reduced pneumonia of patients with advanced lung cancer treated with moderate hypofractionated (3Gy/f)…
- Trial name
- NCT03833193
- Testing
- Hypofractionated radiotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- North China Petroleum Bureau General Hospital
Interstitial Lung Disease, Idiopathic Interstitial Pneumonias
FAPI PET for Lung Fibrosis
This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD). The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in…
- Conditions
- Interstitial Lung Disease, Idiopathic Interstitial Pneumonias, Drug-Induced Pneumonitis, Hypersensitivity Pneumonitis
- Trial name
- FAPI ILD (NCT05365802)
- Testing
- 68Ga-FAPi-46, Computed Tomography, Positron Emission Tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Radiation Pneumonitis
Risk Factors of Radiation Pneumonitis
A prospective observational study to evaluate clinical, dosimetrical, functional, and biological factors in predicting radiation pneumonitis.
- Trial name
- NCT00155909
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- National Taiwan University Hospital