Clinical trials: Radiation Necrosis
Radiation Necrosis, High Grade Glioma (III or IV)
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases
Cerebral radiation necrosis (CRN) is a severe complication of high-dose radiation for brain metastases (BM) or glioma, which can potentially cause significant neurologic symptoms leading to serious morbidity and impaired quality…
- Conditions
- Radiation Necrosis, High Grade Glioma (III or IV), Brain Metastasases, Radiation Toxicity
- Trial name
- BRAINS (NCT06888817)
- Testing
- Bevacizumab, Dexamethasone
- Where
- 6 sites in Netherlands
- Volunteers
- 408 people
- Sponsor
- The Netherlands Cancer Institute
Coronary Artery Disease, Myocardial Infarction
CERROS Pilot Study
The primary objective of this study is to determine whether a reduced radiation protocol (RRP) in which angiograms are acquired at ultralow radiation doses and then processed using spatiotemporal enhancement software can produce…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Coronary Disease, Coronary Stenosis
- Trial name
- CERROS - Pilot (NCT06252350)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Angiowave Imaging
Oral Mucositis, Osteoradionecrosis
Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention
Introduction: There are several manifestations in the oral mucosa resulting from antineoplastic treatments by chemo (QT) or radiotherapy (RT).
- Conditions
- Oral Mucositis, Osteoradionecrosis, Osteonecroses, Bisphosphonate, Osteonecrosis Due to Drugs, Jaw
- Trial name
- NCT04717765
- Testing
- Preventive, LLL Phototherapy and topical Vit E, Curative, LLL Phototherapy and topical Vit E, Preventive, LLL Phototherapy and LPRF
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Brain Tumor
Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases
This research study is investigating the value of an imaging study of the brain called an MRI (which stands for magnetic resonance imaging), utilized in unique way, to delineate whether the tumor has recurred or whether radiation…
- Trial name
- NCT04033497
- Testing
- MRI
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Brigham and Women's Hospital
Anaplastic Thyroid Cancers
A Trial of Adalimumab Combined to Chemotherapy and Radiotherapy in Patients With Anaplastic Thyroid Cancers
The hypothesis is that the particular richness of ATC's microenvironment in TAMs creates a unique opportunity for using Tumor Necrosis Factor blockade during chemotherapy and radiotherapy in order to counteract tumor resistance…
- Trial name
- TAM-RT (NCT02516774)
- Testing
- Adalimumab
- Where
- France
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Brain Metastasis
Methionine and PBR28-PET (Peripheral Benzodiazepine Receptors) in Brain Metastases Following Radiosurgery
The goal of this protocol is to evaluate the potential of PET imaging of amino acid transport and microglial activation to improve the differentiation of tumor recurrence and radiation necrosis in patients with brain metastases…
- Trial name
- NCT02433171
- Testing
- Standard of Care FDG-PET Imaging
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Chest Pain, Myocardial Infarction
The Supplementary Role of Non-invasive Imaging to Routine Clinical Practice in Suspected Non-ST-elevation Myocardial Infarction
Approximately half of patients with acute chest pain, a very common reason for emergency department visits worldwide, have a cardiac cause.
- Conditions
- Chest Pain, Myocardial Infarction, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- CARMENTA (NCT01559467)
- Testing
- Cardiovascular Magnetic Resonance Imaging, Computed Tomography Angiography
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Metastatic Brain Tumors, Progression
Laser Ablation After Stereotactic Radiosurgery
The need for new technologies and devices in the field of neurosurgery is well established. In April 2013, FDA cleared NeuroBlate™ System, minimally invasive robotic laser thermotherapy tool.
- Conditions
- Metastatic Brain Tumors, Progression, Radiation Necrosis, Quality of Life
- Trial name
- LAASR (NCT01651078)
- Where
- 7 sites in United States
- Volunteers
- 44 people
- Sponsor
- Monteris Medical
Secondary Malignant Neoplasm of Brain and Cerebral Meninges
18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis
The purpose of this study is to evaluate whether 18F-fluciclovine PET/CT of the brain, is able to distinguish radiation necrosis from tumor progression in cases where MRI is inconclusive.
- Trial name
- NCT03930173
- Testing
- 18F-fluciclovine, PET/CT of the brain
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Case Comprehensive Cancer Center
Cerebral Radiation Necrosis
Monosialoganglioside Ganglioside in Cerebral Radiation Necrosis
Monosialoganglioside Ganglioside in Cerebral Radiation Necrosis
- Trial name
- NCT03067753
- Testing
- Monosialoganglioside Ganglioside, Methylprednisolone (Steroid Hormone), Prednisolone
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Zhejiang Cancer Hospital
Brain Metastases, Radiosurgery
Imaging Features for the Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis
This trial uses multi-parametric magnetic resonance imaging (MRI) to develop and validate imaging risk score to predict radiation necrosis in participants with brain metastasis treated with radiation therapy.
- Trial name
- NCT05868928
- Testing
- Magnetic resonance imaging (MRI), Diffusion-weighted MRI, Arterial spin labeling (ASL)
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Asan Medical Center
Diabetic Foot, Gangrene; Limb
MetaMet: Bone Cutter Versus Bone Saw for Ray Amputation
Toe amputation is a commonly performed operation for infection and/or ischaemia (tissue death due to lack of blood flow). However, a large number of patients having this surgery ultimately require further amputation due to poor…
- Conditions
- Diabetic Foot, Gangrene; Limb, Wound Infection, Wound Healing Delayed
- Trial name
- MetaMet (NCT05804565)
- Testing
- Bone Saw, Bone Cutter
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Hospital Galway
Nasopharyngeal Carcinoma (NPC), Radiation Injuries
Pseudomembrane Removal for Post-RT Nasopharyngeal Necrosis
This study aims to evaluate the effectiveness and safety of endoscopic nasopharyngeal pseudomembrane removal in reducing radiation-induced nasopharyngeal necrosis in patients with recurrent nasopharyngeal carcinoma who have…
- Conditions
- Nasopharyngeal Carcinoma (NPC), Radiation Injuries, Necrosis
- Trial name
- EPoRN (NCT07552883)
- Testing
- Endoscopic Nasopharyngeal Pseudomembrane Removal
- Volunteers
- 40 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Head and Neck Cancer
SALI-10 Probiotic to Reduce Osteoradionecrosis and Dental Toxicity Following Radiation Therapy for Head and Neck Cancer
This Phase III randomized controlled trial will evaluate whether long-term use of the oral probiotic Streptococcus salivarius strain SALI-10 (SALI-10) can reduce the risk of radiation-related major adverse dental events (MADE) in…
- Trial name
- DIAMOND (NCT07883005)
- Testing
- Standard of Care (SOC), Experimental drug
- Where
- Canada
- Volunteers
- 288 people
- Sponsor
- University Health Network, Toronto
Brain Tumor, Brain Necrosis
Development of MRF for Characterization of Brain Tumors After Radiotherapy
The purpose of this study is to discover the potential convenience and ease of using a Magnetic Resonance Imaging (MRI) technique, named Magnetic Resonance Fingerprinting (or MRF), to achieve high-quality images within a short…
- Conditions
- Brain Tumor, Brain Necrosis, Brain Metastases, Glioma
- Trial name
- NCT06101069
- Testing
- MRF in conjunction with IVIM MRI without contrast
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Radiation Injury, Radiation-Induced Complications
Hyperbaric Oxygen Therapy for Treatment of Severe Radiation-Induced Complications
This study evaluates the safety and effectiveness of hyperbaric oxygen therapy (HBOT) for the treatment of severe radiation-induced complications in patients previously treated with radiotherapy.
- Conditions
- Radiation Injury, Radiation-Induced Complications, Radiation Necrosis
- Trial name
- NCT07422168
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- Slovenia
- Volunteers
- 39 people
- Sponsor
- Institute of Oncology Ljubljana
Brain Metastases
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have…
- Trial name
- NCT04246879
- Testing
- MRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Melanoma
Novel Ga68-PSMA PET/CT-tracer to Differentiate Between Radiation Necrosis and Tumor Progression in Brain Metastases
This study aims to evaluate the diagnostic potential of 68-Gallium PSMA-PET/CT in stereotactic irradiated brain metastases from non-small cell lung cancer, melanoma and breast cancer.
- Conditions
- Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases From Melanoma, Brain Metastases From Breast Cancer
- Trial name
- NCT07511933
- Testing
- 86-Gallium PSMA PET/CT
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute
Invasive Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain
Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases
This trial studies how well dynamic susceptibility contrast-magnetic resonance imaging (MRI) works in determining radiation necrosis and tumor progression in participants with cancer that has spread to the brain and are being…
- Trial name
- NCT03680144
- Testing
- Dynamic Susceptibility Contrast-MRI (DSC-MRI), Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Myocardial Infarction (MI), Radiation Toxicity
A MAajor RAdiation-based PCI Study in STEMI and NSTEMI
In France and Italy, approximately 240,000 percutaneous coronary angioplasties (PCI) are performed annually, with an increasing number of complex procedures, including those involving the left coronary common trunk, a…
- Conditions
- Myocardial Infarction (MI), Radiation Toxicity, Coronary Stenosis, Coronary Thrombosis
- Trial name
- MARAA (NCT06565793)
- Testing
- Non Complex PCI, Complex PCI
- Where
- France
- Volunteers
- 15,630 people
- Sponsor
- Centre Cardiologique du Nord