Clinical trials: Radiation Effect
Non-small Cell Lung Cancer, Radiotherapy Side Effect
Hypofraction Radiotherapy for Locally Advanced Non-small Cell Lung Cancer
Definitive concurrent chemoradiotherapy followed by durvalumab (Pacific protocol) has been the standard modality for stage III locally advanced non-small cell lung cancer.
- Trial name
- NCT05269485
- Testing
- High-dose hypofractionated radiotherapy, Low-dose hypofractionated radiotherapy
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Prostate Cancer, Radiotherapy Side Effect
Ultra Hypofractionnated Radiotherapy With HDR Brachytherapy Boost.
Phase 1-2 study, comparing ultra-hypofractionnated (UH) to a moderately hypofractionnated (MH) radiation therapy, with image guided HDR prostate brachytherapy.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Hypofractionation, Brachytherapy
- Trial name
- HYPO-5 (NCT05786742)
- Testing
- grade and compare reported side effects between groups
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Cervical Neoplasm, Adaptive Radiotherapy
Moderately Hypofractionated Adaptive Radiotherapy for Cervical Cancer
External radiation given in 25 fractions or so together with weekly chemotherapy and followed by 5 or 6 fractions of brachytherapy is the standard of care for patients with locally advanced cervical cancer.
- Conditions
- Cervical Neoplasm, Adaptive Radiotherapy, Radiotherapy; Adverse Effect
- Trial name
- NCT05994300
- Testing
- Moderately hypofractionated adaptive radiotherapy (ART)+ High-dose rate (HDR) Brachytherapy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Head and Neck Cancer, Chronic Periodontitis
Estimation of (suPAR) in Chronic Periodontitis With Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy Side Effect
- Trial name
- HNCs (NCT06529588)
- Testing
- Radiation
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Radiotherapy Side Effect
Comparison Between the Effect of Using Conventional and Digital Oral Positional Radiation Stent
The goal of this clinical trial is to compare between the Effect of Using Conventional and Digital Oral Positional Radiation Stent on Healthy tissues, salivary PH.
- Trial name
- stent (NCT06353724)
- Testing
- conventional oral positioning stent were used during radiation planning and the PTV will be defined and contoured in computed tomography pre irradiation planning, Digital positioning stent
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tanta University
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Radiotherapy Side Effect, Radiodermatitis
Thermal Imaging to Evaluate Skin Toxicity From Radiotherapy
A significant proportion of patients treated with whole-breast or head and neck radiotherapy will experience skin toxicity, i.e. skin dermatitis, which may lead to erythema, dry desquamation and wet desquamation.
- Trial name
- NCT04013711
- Testing
- Thermography
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Effect of Ultraviolet Radiation on Photoaged Skin, Dermatologic Disorders
Safety Study of Bone Marrow Derived Stem Cells on Patients With Cutaneous Photoaging
The purpose of this study is to determine whether a one-time injection of allogeneic mesenchymal bone marrow cells is safe and beneficial in the treatment of photodamage on the face.
- Trial name
- NCT01771679
- Testing
- Allogeneic Mesenchymal Bone Marrow Cells
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Stemedica Cell Technologies, Inc.
Head and Neck Cancer, Radiotherapy Side Effect
The Characterisation of RT Caries.
Overcoming limitations of previous studies, the following research project will assess the most significant acute and long-term complications of RT that affect HNC patients: oral mucositis, dry mouth feeling, taste alteration and…
- Trial name
- NCT03397823
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- King's College London
Radiotherapy Side Effect
SBRT With S1 Combined With Endostar in the Treatment of Lung Cancer
Human recombinant endostatin preclinical studies have shown that the drug can inhibit endothelial cell proliferation, angiogenesis and tumor growth, still can directly induce lung cancer cell apoptosis, multiple clinical studies…
- Trial name
- SBRTLCES (NCT04274270)
- Testing
- Endostar
- Where
- 16 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Bone Metastases, Radiotherapy Side Effect
A Prospective Randomized Trial of High Dose Versus Standard Dose Stereotactic Radiotherapy for Pain Control in Patients With Bone Metastases
In the present study, we will prospectively evaluate the pain response and treatment failure rate to determine the most favorable radiation dose in single fraction stereotactic radiotherapy using the modern highly conformal…
- Trial name
- NCT04063254
- Testing
- Stereotactic Radiotherapy
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Radiation Effects
Brain Radiation Exposure and Attenuation During Invasive Cardiology Procedures
Invasive cardiac procedures involve procedural guidance with x-rays in the form of fluoroscopy. X-ray exposure poses a potential risk of acute and long-term complications to staff involved in these procedures.
- Trial name
- BRAIN (NCT01910272)
- Testing
- All subjects are wearing the non-lead attenuation cap (BLOXR)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego