Clinical trials: Pupillometry
Children Brain Injury
Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Intracranial hypertension (ICH) is a common and serious complication in children admitted to pediatric intensive care units. It is primarily caused by traumatic brain injury but can also result from brain malformations, brain…
- Trial name
- OSMOPUPILLO (NCT06642896)
- Testing
- pupillometer
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
Alzheimer s Disease, Major Depressive Disorder (MDD)
VR Pupillometry in Cognitive Impairment
With disease-modifying therapies emerging for dementia and related conditions, identifying cognitive decline as early as possible is increasingly important.
- Conditions
- Alzheimer s Disease, Major Depressive Disorder (MDD), Mild Cognitive Impairment, Dementia
- Trial name
- NCT07402356
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry
Critical Illness
Pupillometry and Nociception Level Index for the Evaluation of Pain in Intensive Care Unit.
Pain is a frequent symptom in the intensive care unit (ICU). Critical ill patients are often intubated and sedated which makes self-evaluation of pain impossible.
- Trial name
- NOCI-ICU (NCT05469841)
- Testing
- Systemic pain assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Optic Neuritis
Pupillometry Dynamic Measures in Patients Without Ocular or Neurological Disease
Retrobulbar optic neuritis (NORB) is the damage to the optic nerve caused by inflammation. It causes a rapidly progressive and painful visual loss, often among young subjects.
- Trial name
- PCT (NCT02894281)
- Testing
- pupillary light reflex
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Pain
Measuring Analgesic Interventions
It is generally recognized that pain assessment and management especially in newborns, children and other nonverbal populations is an unmet need.
- Trial name
- NCT03794362
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Julia Finkel
Eligible for Day Case Surgery
Prediction of Pre-operative Anxiety by Heart Variability and Pupillometry
The purpose of this study is to determine whether heart rate variability levels and pupillometric measures are effective objective predictors of anxiety among patients before surgery.
- Trial name
- INNOVANX (NCT04154410)
- Testing
- Analgesia Nociception Index, algiscan
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cluster Headache, Sleep
Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients
Cluster headache is one of the most painful headaches, characterized by recurring episodes of unilateral, periorbital pain, which is accompanied by autonomic symptoms that seem to be of both sympathetic and parasympathetic…
- Trial name
- NCT03010189
- Testing
- Actigraphy, Heart-rate variability monitoring, Pupillometry
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Postoperative Pain
Monitoring Pupillary Reflex Dilatation for Optimized Postoperative Opioid Delivery Before Extubation.
The study will be designed to investigate the effect of pupillometry guided compared to non-PPI-guided postoperative pain therapy, conducted immediately at the end of surgery before extubation, on total postoperative opioid…
- Trial name
- NCT04594382
- Testing
- Pupillometry-Opioid treatment, Pupillometry -standardized opioid treatment
- Where
- Austria
- Volunteers
- 140 people
- Sponsor
- Medical University of Vienna
Postoperative Pain, Postoperative Pain Management
Evaluating the Efficacy and Utility of the Automated Pupillometer in Pain Assessment and Opioid Administration Guidance During the Perioperative Period: A Randomized Controlled Trial
Effective intraoperative and postoperative pain management is critical for patient comfort and recovery, yet traditional methods for assessing pain under general anaesthesia are limited by their subjective nature and reliance on…
- Trial name
- NCT07614607
- Testing
- Opioid Analgesic, automated pupillometry
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Bilateral Sensorineural Hearing Loss, Unilateral Sensorineural Hearing Loss
Pupillometry Techniques Usage to Quantify the Programming Parameters Effect in the Auditory Effort in Zti Opticon Cochlear Implant Adult Users
The aim of this study is to establish the connection between the cochlear implant programming parameters with the auditory effort associated with the speech perception evaluated by pupillometry techniques in different audiometric…
- Trial name
- NCT05300230
- Testing
- Neuro Zti cochlear implant and Neuro 2 sound processor
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Pupillary Function, Abnormal, Cerebral Aneurysm
Impact of Acute Cerebral Diseases on the Autonomous Nervous System: Progression and Correlation to Therapy and Outcome
The pupilometer determines the alteration of the pupil diameter after a defined light stimulus. In this study data is collected from pupilometer measurements of patients with an acute cerebral disease.
- Trial name
- Pupillometry (NCT02999659)
- Testing
- Pupilometer
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- RWTH Aachen University
Seasonal Affective Disorder, Visual Impairment
Seasonal Affective Disorder and Visual Impairment
As a subtype of major depressive disorder, seasonal affective disorder (SAD) or winter depression causes severe reductions in both quality of life and productivity and results in high morbidity and frequent sick leave (1).
- Trial name
- NCT03403959
- Testing
- light therapy
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Hearing Impaired Children
Hearing Impairment in Children: Pupillometry and Hearing Thresholds Assessment
The results of the previous study on auditory effort in young children with cochlear implants show that pupils respond to the presence or the absence of the perceived stimuli.
- Trial name
- NCT06317493
- Testing
- Stimuli
- Where
- 5 sites in Italy, Slovenia
- Volunteers
- 180 people
- Sponsor
- IRCCS Burlo Garofolo