Clinical trials: Pulse Pressure Variation
Elective Posterior Lumbar Spinal Fusion
Value of Pulse Pressure Variations and Corrected Flow Time in Esophageal Doppler as a Predictor of Fluid Responsiveness in Prone Position During Spinal Surgery
In patients under mechanical ventilation, Usefulness of dynamic indices based on the heart-lung interactions for guiding volume resuscitation has been well validated.
- Trial name
- NCT01646359
- Testing
- 1.Esophageal doppler monitor, 2. philips Intelivue MP70 monitors
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Yonsei University
Sepsis, Critical Illness
Lung Ultrasound Score and Inferior Vena Cava Diameter Compared to Pulse Pressure Variation
Evaluation and management of intravascular volume are a central challenge for the critical ill patients. Hypotensive patients are commonly resuscitated with intravenous crystalloid fluid as a recommendation for treatment of many…
- Trial name
- NCT05980494
- Testing
- normal Saline, lung ultrasound, inferior vena cava measurements
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Fayoum University Hospital
Hypovolemia, Somatic Pain
Influence of Variations of Systemic Venous Return on Analgesia Nociception Index (ANI) During General Anaesthesia
The purpose of this study is to determine whether the value of analgesia nociception index (ANI) is influenced by variations of systemic venous return (cardiac preload) under general anaesthesia.
- Trial name
- NCT02193412
- Testing
- noxious stimulus, change in operating table slope: head-down tilt position, change in operating table slope: head-up tilt position
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Arterial Hypotension, Anaesthesia
Effects of Phenylephrine on Cardiac Preload
In patients under general anesthesia, episodes of hypotension are often treated with phenylephrine. The effect of phenylephrine is conventionally attributed to afterload increase.
- Trial name
- NCT02739399
- Testing
- Phenylephrine
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Arterial Hypotension
Effect of Phenylephrine Versus Norepinephrine on Venous Return
Induction of general anesthesia often induces a decrease in the mean arterial blood pressure (MAP) caused by arterial and venous dilatation.
- Trial name
- NCT03872570
- Testing
- Phenylephrine, Norepinephrine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Anesthesia, Perioperative/Postoperative Complications
Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP
This is an observational, prospective, single-centre study that will focus on patients undergoing major non-cardiac surgery requiring invasive mechanical ventilation and invasive blood pressure monitoring Hypotheses: A positive…
- Conditions
- Anesthesia, Perioperative/Postoperative Complications, Hypovolemia, Haemodynamic Instability
- Trial name
- HiPEEP (NCT06123039)
- Testing
- Tidal Volume Challenge, Recruitment maneuver obtaining individualised PEEP
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Hypovolemia
Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Spontaneously Breathing Patients
The management of septic shock patients includes the infusion of fluids, however fluids may be deleterious if the patient does not respond by increasing cardiac output.
- Trial name
- NCT06480942
- Testing
- Detection of preload responders by a PLR test
- Where
- France
- Volunteers
- 39 people
- Sponsor
- CHU de Reims
Respiration, Artificial
The Correlational Study of PPV in Various VT in Mechanically Ventilated Patients
Mesquida, J et al showed there was a significant linear correlation between pulse pressure variations under tidal volume 6 ml/kg and 8 ml/kg in patients after the resuscitation phase of severe sepsis and septic shock.
- Trial name
- NCT01950949
- Testing
- 300 ml Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection infusing in 15 minutes if PPV under VT 8 ml/kg was larger than 13% in the initial investigation
- Volunteers
- 69 people
- Sponsor
- Yi Liu
Ischemic Heart Disease
Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)
Pulse pressure variation (PPV) known as a dynamic preload index is increasingly being used for guide of fluid management under various clinical situations.
- Trial name
- NCT01041742
- Testing
- fluid loading
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Posterior Fossa Tumor, Brain Tumor Adult
Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance
To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?
- Trial name
- NCT06595667
- Testing
- Pulse pressure variation, Central venous pressure
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chiang Mai University
Haemodynamics, Fluid Responsiveness
Factors Influencing of Pulse Pressure Variation (PPV)
The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.
- Conditions
- Haemodynamics, Fluid Responsiveness, Pulse Pressure Variation
- Trial name
- FacPPV (NCT04802668)
- Testing
- Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume, spontaneous breathing and no spontaneous breathing
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Southeast University, China
Fluid Responsiveness
Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness
In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed.
- Trial name
- PHOENIX (NCT06390423)
- Testing
- Passive leg raise, SVI via bioreactance, Echo based VTI
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- CentraCare
Hypotension
Predictability of the Pulse Pressure Variation (PPV) During Spontaneous Ventilation on the Incidence of Hypotension During Induction of Anesthesia
The purpose of this study is to find out the predictability of the pulse pressure variation during spontaneous ventilation on the incidence of hypotension during induction of anesthesia.
- Trial name
- NCT02208570
- Testing
- PPV>14%, Volume loading, PPV<14%
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Seoul National University Hospital
Hypovolemia
Response of Pulse Pressure Variation in PA Catheter Tracing to IV Fluid Bolus in the ICU
The investigators hypothesize that analysis of blood pressure will allow doctors to predict whether or not blood flow from the heart (cardiac output) increases after intravenous fluids are given.
- Trial name
- NCT02419404
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Pulse Pressure Variation, Spontaneously Breathing
Pulse Pressure Variation in Spontaneously Breathing Patients
The investigators hypothesized that pulse pressure variation (PPV) could predict fluid responsiveness in spontaneously breathing patients undergoing anesthesia induction.
- Trial name
- NCT01402934
- Testing
- Hydroxyethyl starch solution (Voluven) infusion
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Circulation, Drug Dose
Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation
Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.
- Conditions
- Circulation, Drug Dose, Calculated SAP
- Trial name
- NCT02201121
- Testing
- Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation
- Volunteers
- 94 people
- Sponsor
- Chinese PLA General Hospital
Thoracic Surgery, Fluid-therapy
GDT-PPV Protocol in Thoracic Surgery
Peri-operative fluid-therapy is extremely important in thoracic surgery, because excessive administration of fluids during one-lung ventilation is correlated to an increasing risk of postoperative respiratory complications.
- Trial name
- NCT04865874
- Testing
- PPV-GDT, Zero-balance
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Circulatory Failure
Changes in PPV Induced by PLR Test to Predict Fluid Responsiveness in ICU
The passive leg raising (PLR) test is a reversible preload challenge of around 300 mL of blood that can be repeated as frequently as required without infusing a drop of fluid.
- Trial name
- VPP-ImPRoVE (NCT03225378)
- Testing
- Fluid loading of 500 mL of crystalloid solution, Passive Leg Raising test
- Where
- 12 sites in France
- Volunteers
- 286 people
- Sponsor
- Centre Hospitalier Arras
Peripheral Vein, Arterial Wave Reflections
Deep Learning Model for Predicting a Peripheral Venous Waveform-based Pulse Pressure Variation
Pulse pressure variation is a monitoring index that indicates the response to fluid therapy in patients receiving mechanical ventilation, and is used as a reference for patients with unstable hemodynamic conditions.
- Conditions
- Peripheral Vein, Arterial Wave Reflections, Pulse Pressure Variation, Stroke Volume Variation
- Trial name
- NCT06734650
- Testing
- peripheral waveform collection
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Hemodynamic Instability, Cardiac Output, High
Individualized Perioperative Hemodynamic Goal-directed Therapy in Major Abdominal Surgery (iPEGASUS-trial)
To evaluate the impact of perioperative, algorithm driven, hemodynamic therapy based on individualized fluid and cardiac output optimization on postoperative moderate and severe complications in patients undergoing major…
- Conditions
- Hemodynamic Instability, Cardiac Output, High, Peroperative Complication
- Trial name
- iPEGASUS (NCT03021525)
- Testing
- Individualized Goal Directed Therapy, Control Group
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 380 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf