Clinical trials: Pulse Pressure Variation
Perioperative/Postoperative Complications, C.Surgical Procedure; Digestive System
Non-invasive Early Goal Directed Therapy in Colorectal Surgery: a Feasibility Study
The Nexfin monitoring system offers a complete non-invasive approach to a continuously estimation of blood pressure, CI and PPV by means of finger-cuff based pulse contour analysis.
- Trial name
- NCT02559141
- Testing
- Dobutamine
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Schleswig-Holstein
Kidney Transplantation
Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation
The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.
- Trial name
- NCT02459470
- Testing
- Fluid loading
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Samsung Medical Center
Stroke Volume Variation
Effect of Wide Pulse Pressure on the Predictability of Stroke Volume Variation for Fluid Responsiveness in Patients Undergoing Off-pump Coronary Artery Bypass Graft
The investigators examined the predictability of stroke volume variation for fluid responsiveness in patients with wide pulse pressure undergoing off-pump coronary artery bypass graft
- Trial name
- NCT01404455
- Testing
- HES 130/0.4 (VoluvenⓇ, Fresenius Kabi, Graz, Austria) 500mL loading
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Severance Hospital
Laparoscopic Surgery
The Use of Tidal Volume Challenge of Dynamic Parameters During Laparoscopic Surgery
Laparoscopy is increasingly used for major abdominal and pelvic surgery. As this approach is also recommended in elderly patients with serious comorbidities, optimal fluid therapy guidance during this procedure is important.
- Trial name
- NCT03467711
- Testing
- tidal volume challenge, volume expansion
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Scoliosis, Spinal Fusion
Is Pleth Variability Index (PVI) a Surrogate for Pulse Pressure Variations (PPV) in Pediatric Spine Fusion (SF) Surgery?
Spine fusion is an involved procedure during which patients are at risk for significant intra-operative blood loss.This study will compare 2 ways of determining fluid status and response to fluid administration.
- Trial name
- NCT00994656
- Testing
- Masimo multi-wavelength pulse co-oximeter
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's Hospital of Philadelphia
General Anaesthesia
Accuracy of CNAP PPV Under General Anaesthesia
Noninvasive pulse pressure variation for the guidance of perioperative fluid therapy is compared with the gold standard of invasive measurements. Cardiac output is derived by the PICCO monitor.
- Trial name
- NCT02166580
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- University Hospital Schleswig-Holstein
Cardiac Surgical Procedures, Thoracic Surgical Procedures
Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition
Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal.
- Conditions
- Cardiac Surgical Procedures, Thoracic Surgical Procedures, Sternotomy
- Trial name
- NCT02457572
- Testing
- Valsalva maneuver, Fluid loading
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Samsung Medical Center
Artificial; Complications, Heart
Stroke Volume Variations and Pulse Pressure Variations Undergoing Artificial Pneumothorax Surgery
Stroke volume variation (SVV) and pulse pressure variation (PPV) have been thought to be sensitive predictors of fluid responsiveness in mechanically ventilated participants.
- Trial name
- NCT05644405
- Testing
- FloTrac Vigileo
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Laparoscopic Surgery
Dynamic Preload Dependence Indices in Laparoscopic Surgery
A goal-directed fluid management is definitely beneficial in high risk surgery. The fluid administration can be directed by cardiac output monitoring which evaluate the response to repeated fluid challenge or by preload…
- Trial name
- VPP Coelio (NCT02541656)
- Testing
- Study of preload dependence indices after volume expansion in laparoscopy with Saldinger technique.
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Fluid Overload, Mechanical Ventilation
Tidal Volume Challenge to Assess Volume Responsiveness
The purpose of this study is to investigate the ability of changes in PPV and SVV after Tidal Volume Challenge to predict fluid responsiveness in patients undergoing general anesthesia with protective mechanical ventilation.
- Trial name
- NCT05254951
- Testing
- Tidal Volume Challenge
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Neurological Diseases or Conditions, Fluid Responsiveness
A Gray Zone Approach to Stroke Volume Variation Derived From NICOM
Optimal fluid management has been considered as crucial part to determine postoperative outcome and organ function. Recently developed, non invasive cardiac output measurement(NICOM, Cheetah Medical, Portland, OR)has enabled…
- Conditions
- Neurological Diseases or Conditions, Fluid Responsiveness, Non Invasive Cardiac Output Monitoring, Gray Zone
- Trial name
- NCT01898975
- Testing
- 500ml fluid loading
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Lung; Congestive, Liver Transplantation
Effect of Fluid Management Guided by Pulse Pressure Variation Vs Central Venous Pressure on Lung Water Assessed by Lung Ultrasound During Liver Transplantation
the aim in this study to assess the effect of fluid management in patient undergoing orthotopic liver transplantation either by using pulse pressure variation or by central venous pressure.
- Trial name
- NCT03243526
- Testing
- fluid therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Kidney Failure, Respiratory Failure
Observational Study of Blood Pressure Measurements and Continuous Dialysis
Dialysis is used to control the fluid balance and metabolic state of patients with kidney disease. Control of the metabolic state, via electrolytes, can be monitored using labs that are routinely drawn from patients undergoing…
- Conditions
- Kidney Failure, Respiratory Failure, Critical Illness, Shock
- Trial name
- NCT01286506
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Chicago
Abdominal Surgery
Comparison of Respiratory Variations of the Pulse Oximetry Plethysmographic Raw Signal and Pulse Pressure During Abdominal Surgery (PLETHYSMO)
The waveform plethysmographic signal can be used to establish an index for predicting fluid responsiveness (∆POP: respiratory variation of the plethysmographic waveform of pulse oximetry).
- Trial name
- PLETHYSMO (NCT02817893)
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Intraoperative Hypotension
Phenylephrine and Pulse Pressure Variability
The purpose of this research study is to determine how vasopressors affect a measure of how intravenous fluid is administered in people undergoing surgery who have low blood pressure called Pulse Pressure Variability (PPV).
- Trial name
- NCT05011357
- Testing
- Phenylephrine, Saline Control
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Goal-directed Fluid Therapy, Hemodynamics Instability
Multi-center Trial of Goal-directed Fluid Management Based on Pulse Pressure Variation Monitoring
Background: Intraoperative fluid therapy guided by mechanical ventilation-induced pulse-pressure variation (PPV) may improve outcomes after major surgery. It was tested this hypothesis in a multi-center study.
- Conditions
- Goal-directed Fluid Therapy, Hemodynamics Instability, High-risk Surgery, Pulse-pressure Variation
- Trial name
- GDTPPV (NCT03128190)
- Testing
- Pulse pressure variation monitoring
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
Cardiac Output, Low
Effects of Inspiratory Flow Waveforms on Preload
The clinical usefulness of inspiratory flow pattern manipulation during mechanical ventilation remains unclear. The aim of this study was to investigate the effects of different inspiratory flow waveforms, i.e.
- Trial name
- NCT01892696
- Testing
- varying inspiratory flow waveforms
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- Military Hospital of Tunis
Intraoperative Fluid Volume, Hemodynamics
Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis
pulse pressure variation based intraoperative fluid therapy versus traditional fluid therapy for colonic cancer patients undergoing mass resection and anastomosis for maintaining adequate hydration without complications.
- Conditions
- Intraoperative Fluid Volume, Hemodynamics, Serum Lactate, Intestinal Edema
- Trial name
- NCT05502835
- Testing
- pulse pressure variation, conventional fluid management
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Hemodynamic Instability, Hypovolemia
Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness
Hemodynamic instability remains one of the leading causes of morbidity and mortality among critically ill patients in intensive care units. One major contributor to this instability is intravascular fluid deficit.
- Conditions
- Hemodynamic Instability, Hypovolemia, Critical Illness, Pulse Pressure Variation
- Trial name
- NCT07304661
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Izmir Katip Celebi University
General Critically Ill Patients With Hypovolemia
Arterial Pressure Derived Dynamic Parameters to Detect Preload Responsiveness in Mechanically Ventilated Patients Under Spontaneous Mode
The management of septic shock patients includes the infusion of fluids, however fluids may be deleterious if the patient does not respond by increasing cardiac output.
- Trial name
- NCT06495489
- Testing
- Detection of preload responders by a PLR test
- Where
- France
- Volunteers
- 34 people
- Sponsor
- CHU de Reims