Clinical trials: Pulpitis
Pain, Postoperative Pain
Efficacy of Different Drugs to Control Post Root Canal Treatment Pain
Root canal therapy will ideally eliminate post-endodontic pain but occasionally analgesics are needed to diminish the pain [Owatz et al 2007].
- Conditions
- Pain, Postoperative Pain, Irreversible Pulpitis
- Trial name
- NSAID (NCT02417337)
- Testing
- Paracetamol, Ibuprofen, Mefenamic Acid
- Where
- Sudan
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Khartoum
Root Canal Infection
Success Rate of 4 Injection Protocols for Mandibular First Molars With Symptomatic Irreversible Pulpitis
Achieving profound anesthesia during endodontic treatment of mandibular molars with symptomatic irreversible pulpitis is still a demanding clinical challenge.
- Trial name
- NCT04929522
- Testing
- local anesthesia
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Deep Dental Caries
Clinical Comparison of Vital Pulp Capping Restorative Protocols
At present, dentistry aims for conservative treatments with the goal of maintaining as much tooth structure as possible. Dental caries remains the most prevalent chronic disease worldwide; these lesions can progress rapidly and…
- Trial name
- NCT02635867
- Testing
- Indirect Pulp capping-Resin-modified calcium silicate - TheraCal, Indirect Pulp capping-Calcium hydroxide - Dycal, Indirect Pulp capping-Resin-based dentin bonding agent
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Root Canal Infection, Endodontic Disease
Occurrence of Post-op Pain Following Gentlewave
This is a clinical study that will investigate the occurrence of post-operative discomfort following the use of the Gentlewave System for root canal disinfection and irrigation.
- Conditions
- Root Canal Infection, Endodontic Disease, Endodontic Inflammation, Post-Operative Pain
- Trial name
- NCT03635515
- Testing
- Gentlewave, Standard Endodontic Protocol
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pulpitis - Irreversible
Assessing Success of MTA and Pre-mixed Bioceramic in Mature Teeth With Irreversible Pulpitis With Full Pulpotomy.
Although many pulpotomy agents are commercially available, there is a dearth of clinical research comparing the efficacy of these agents in treating individuals with irreversible pulpitis.
- Trial name
- GCP (NCT05853185)
- Testing
- Pro Root MTA®, EBRRM®
- Where
- Pakistan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Carious Exposure, Human Permanent First and Second Molars
RCT of Pulp Capping Over Carious Exposure in Adults
This multicentre study was a randomized, controlled, parallel, patient-blinded, two-arm superiority trial with a 1:1 allocation ratio that followed the CONSORT guidelines.The aim of this study was to investigate whether MTA is…
- Conditions
- Carious Exposure, Human Permanent First and Second Molars, Mature Teeth, Proximal Caries
- Trial name
- NCT01224925
- Testing
- Direct pulp capping with Dycal, Direct pulp capping
- Where
- 4 sites in Lithuania, Norway
- Volunteers
- 80 people
- Sponsor
- University of Tromso
Irreversible Pulpitis (Toothache)
Effect of Buffered Numbing Solution on Patients With Toothaches
The purpose of this study is to determine the effect of buffered lidocaine (a numbing solution) on the ability to numb patients with toothaches.
- Trial name
- NCT01868776
- Testing
- buffered lidocaine, nonbuffered lidocaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Patients with painful molars will be randomly assigned to 2 different groups: GentleWave and EndoActivator. The root canals will be completed using identical protocols except in the mode of delivery and activation of irrigation…
- Trial name
- NCT04552132
- Testing
- Multisonic vs Sonic activation of irrigants
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Pain, Postoperative
Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy
Aim: The purpose of this study was to compare ibuprofen versus an ibuprofen/acetaminophen combination for postoperative pain control in patients requiring root canal treatment with a tooth that is painful to cold and biting.
- Trial name
- NCT03631433
- Testing
- Ibuprofen 600 mg, ibuprofen 600 mg and acetaminophen 650 mg
- Volunteers
- 102 people
- Sponsor
- Ohio State University
Symptomatic Irreversible Pulpitis
Combination of Buffered Anesthetic to Treat Mandibular Molars
The purpose of this study is to determine whether a combination of anesthetics (numbing medicine) will adequately anesthetize teeth over a different combination.
- Trial name
- NCT06047366
- Testing
- Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Symptomatic Irreversible Pulpitis, Post Operative Pain
Effect of Preoperative Tramadol and Naproxen Sodium on Post Operative Pain
The goal of this clinical trial is to compare in Tramadol, Naproxen sodium and Placebo in participants presenting with irreversible pulpitis in their mandibular molar teeth.
- Trial name
- NCT05982392
- Testing
- Tramadol, Naproxen Sodium
- Where
- Pakistan
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Irreversible Pulpitis, Apical Periodontitis
Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodontitis
Statement of problem: Although performing full pulpotomy in mature permanent molars with irreversible pulpitis showed success rates comparable to RCT, there is a growing need for further studies in order to determine the…
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpitis
- Trial name
- NCT06767371
- Testing
- Patients with mature permanent molars diagnosed with severe pulpitis with apical periodontitis to be treated with full pulpotomy., Patients with mature permanent molars diagnosed with moderate pulpitis without apical periodontitis to be treated with full pulpotomy., Teeth with irreversible pulpitis
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Misr International University
Pulpitis
Evaluation of Hyaluronic Acid Pulpotomies in Primary Molars
In this study, 120 primary molar teeth from healthy children aged between 5 and 9 and who apply to Marmara University Faculty of Dentistry, Department of Pediatric Dentistry will be subjected to pulpotomy treatments.
- Trial name
- NCT04115358
- Testing
- Hyaluronic acid: Gengigel teething, Formocresol Buckley formula: Formacresol, Ferric sulfate: ViscoStat
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Marmara University
Irreversible Pulpitis
Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
The purpose of this trial is to study the ability of a frequently used dental anesthetic (articaine) to achieve complete numbness of a diseased tooth with the most commonly used injection technique in the lower jaw (inferior…
- Trial name
- ARTIC (NCT01496846)
- Testing
- IANB Articaine, SUP Articaine, SUP Lidocaine
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- University of Michigan
Reversible Pulpitis, Ibuprofen
Pain Management in Teeth With Reversible Pulpitis
Effective intraoperative pain management is vital in paediatric dentistry, especially during vital pulp therapy (VPT) for reversible pulpitis.
- Trial name
- NCT07114198
- Testing
- Ibuprofen 10 mg/kg
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Inonu University
Symptomatic Irreversible Pulpitis
Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
The purpose of this study is to determine whether one type of anesthetic (numbing medicine) will work better at numbing the nerve in a tooth than using a different type of anesthetic.
- Trial name
- NCT05227300
- Testing
- Onset Sodium Bicarbonate Inj., 8.4%, USP Neutralizing Additive Solution, 2% lidocaine with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University