Clinical trials: Pulp Necrosis, open to volunteers
Pulp Necrosis, Apical Periodontitis
Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.
Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment.
- Trial name
- NCT07688005
- Testing
- Sodium Hypochlorite 3% Solution, Emblica officinalis Solution
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Pulp Necroses
Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars
The purpose of this study is to compare the efficacy of GentleWave versus EdgePro irrigation in the disinfection of infected root canals of human permanent teeth with necrotic pulp.
- Trial name
- NCT06554366
- Testing
- GentleWave, EdgePro laser irrigation, Irrisafe passive ultrasonic irrigation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pulp Necrosis, Apical Periodontitis
PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth
This clinical trial will compare platelet-rich plasma (PRP)-assisted regenerative endodontic treatment with conventional root canal treatment in mature permanent teeth with pulp necrosis and apical periodontitis.
- Trial name
- NCT07918664
- Testing
- PRP-Assisted Regenerative Endodontic Treatment, Conventional Root Canal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- TC Erciyes University
Pulpal Necrosis
Triple Antibiotic Paste vs Simvastatin for Lesion Sterilization and Tissue Repair in Primary Molars.
This randomized, double-blinded, parallel-controlled clinical trial aims to compare the effectiveness of Triple Antibiotic Paste (TAP) and Simvastatin in Lesion Sterilization and Tissue Repair (LSTR) of primary molars with pulp…
- Trial name
- LSTR (NCT07264842)
- Testing
- Lesion Sterilization and Tissue Repair using Simvastatin., Lesion Sterilization and Tissue Repair using Triple Antibiotic Paste.
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dow University of Health Sciences
Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp
Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.
To compare the effect of 1% melatonin gel versus calcium hydroxide as intra canal medication in necrotic mandibular premolars on: Intensity of postoperative pain. Bacterial load reduction. Periapical (MMP-9) level.
- Trial name
- RCT (NCT07495605)
- Testing
- 1% melatonin gel, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 50 people
- Sponsor
- Cairo University
Apical Periodontitis, Necrotic Pulps
A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits
This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation.
- Conditions
- Apical Periodontitis, Necrotic Pulps, Single Rooted Teeth
- Trial name
- NCT07101003
- Testing
- single visit instrumentation, multiple visit instrumentation
- Volunteers
- 28 people
- Sponsor
- Marwa Hisham Mohamed Salah Eldin
Necrotic Pulps With no Apical Periodontitis
Influence of Continuous Rotation Versus Reciprocation Motion of MG3 Blue Rotary File on Postoperative Pain and Intracanal Bacterial Reduction of Teeth With Necrotic Pulps.
he main objective of this study is to compare the impact of two different file motions-continuous rotation versus reciprocation-using the same endodontic file system (MG3 Blue rotary files) on postoperative pain and the amount of…
- Trial name
- NCT07916987
- Testing
- Engine driven files utilized in reciprocation motion, engine driven rotary files utilized in continuous rotation motion
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Immature Permanent Teeth With Open Apex, Pulp Necrosis
Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process
This study assess the ability of Asiaticoside based Intracanal medication compared to the commonly used Intracanal medicament ( calcium hydroxide Ca(OH) 2) on the outcome of the revascularization process in immature permanent…
- Trial name
- NCT07802340
- Testing
- Intracanal medication
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Irreversible Pulpitis, Apical Periodontitis
Bite Force Measurements
ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids.
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
- Trial name
- NCT06843525
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Rutgers, The State University of New Jersey
Pulpitis - Irreversible, Pulp Necrosis
Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates…
- Conditions
- Pulpitis - Irreversible, Pulp Necrosis, Apical Periodontitis
- Trial name
- DTNV (NCT07297836)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Pain, Postoperative, Root Resorption
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment.
- Conditions
- Pain, Postoperative, Root Resorption, Persistent Infection, Necrotic Pulp
- Trial name
- NCT06926322
- Testing
- Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pulp Necrosis
Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar
This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars.
- Trial name
- NCT07435883
- Testing
- triton irrigation protocol, conventional irrigation group
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- sara hosny mostafa
Dental Caries, Pulp Necrosis
Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars
This randomized clinical trial aims to evaluate and compare the antimicrobial efficacy of Moringa Oleifera leaf extract versus sodium hypochlorite as root canal irrigants in pulpectomy of nonvital primary molars in pediatric…
- Conditions
- Dental Caries, Pulp Necrosis, Primary Tooth Pulpectomy, Pediatric Dentistry
- Trial name
- MORvNAOCL (NCT06971055)
- Testing
- Sodium hypochlorite, Moringa Oleifera Leaf Extract
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis, Pulpitis
Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure…
- Trial name
- NCT07546773
- Testing
- Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Suez Canal University
Pulp Therapy, Pulpitis - Irreversible
Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp
Preserving primary teeth until their normal exfoliation time is crucial for maintaining the child's normal function, esthetics, arch integrity, and correct eruption of permanent successors.
- Conditions
- Pulp Therapy, Pulpitis - Irreversible, Pulp Necrosis
- Trial name
- NCT07230717
- Testing
- Pulpotomy, Pulpectomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajman University
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Periapical Periodontitis, Dental Pulp Necrosis
Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars
This randomized controlled trial will investigate if maintaining apical patency-a technique where a small file is gently moved past the root's end during cleaning-affects pain after a root canal.
- Trial name
- IMAP-Pain (NCT07239752)
- Testing
- Patency Group, Standard Root Canal Instrumentation
- Volunteers
- 48 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Pulp Necrosis, Apical Periodontitis
Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods
This randomized clinical trial aims to evaluate the antibacterial efficacy and treatment outcomes of three different final irrigation protocols during root canal therapy: 2.5% sodium hypochlorite alone, sodium hypochlorite with…
- Conditions
- Pulp Necrosis, Apical Periodontitis, Endodontic Treatment
- Trial name
- ENDOABG (NCT06959602)
- Testing
- Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- National and Kapodistrian University of Athens
Dental Caries, Teeth Loss
The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent Teeth
Dentists commonly use bitewing radiographs (dental X-rays) together with a visual-tactile (clinical) examination to detect cavities between the back teeth.
- Conditions
- Dental Caries, Teeth Loss, Necrosis of Pulp, Irreversible Pulpitis
- Trial name
- BROCC (NCT07882693)
- Testing
- Visual-tactile caries examination, Visual-tactile caries examination and bilateral bitewing radiography
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jukka Leinonen
Pulp Necrosis
This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit
This randomized clinical trial aims to compare the step-back and step-down root canal preparation techniques in patients with pulp necrosis. The study will evaluate which technique results in less postoperative pain.
- Trial name
- NCT07290192
- Testing
- Step down technique
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi