Clinical trials: Pulp Disease, Dental
Pulpitis - Irreversible, Pulpitis
Vital Pulp Therapy vs. Root Canal Treatment in Mature Teeth With Irreversible Pulpitis
This study was designed as a prospective, randomized, controlled clinical trial with parallel groups and double blinding, following the principles of the Declaration of Helsinki for human experimentation and in accordance with…
- Conditions
- Pulpitis - Irreversible, Pulpitis, Pulpotomy, Root Canal Therapy
- Trial name
- NCT07355140
- Testing
- VPT Group and RCT Group
- Where
- Venezuela
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universidad Central de Venezuela
Necrotic Pulp, Regenerative Endodontic Procedures
Maximum Occlusal Bite Force of Necrotic Permanent Teeth Treated by Regenerative Technique: Randomized Clinical Trial
Further investigation is warranted to ascertain whether the regaining of sensibility and nerve function in regenerated teeth leads to the re-establishment of the proprioceptive protective mechanism inherent in vital teeth.
- Conditions
- Necrotic Pulp, Regenerative Endodontic Procedures, Bite Force
- Trial name
- NCT06934317
- Testing
- measurement of maximum bite force using bite fork, conventional root canal treatment, pulp revascularization by induced bleeding
- Where
- Jordan
- Volunteers
- 40 people
- Sponsor
- Lama Awawdeh
Periapical Periodontitis, Pulpitis
Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments
Background: Pulpitis and apical periodontitis are inflammatory conditions of the dental pulp and periapical tissues, primarily caused by microbial invasion.
- Trial name
- CR-ET (NCT07418840)
- Testing
- Root canal treatment and non surgical endodontic retreatment
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Necrotic Pulp
Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial
This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp.
- Trial name
- NCT07327996
- Testing
- Calcium Hydroxide Intracanal medication, mesoporous silica nanoparticles paste, Calcium Hydroxide + mesoporous silica nanoparticles
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Pulpitis, Pulpitis - Irreversible
Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples
This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible…
- Conditions
- Pulpitis, Pulpitis - Irreversible, Pulp Inflammation, Healthy Pulp
- Trial name
- NCT06938191
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Pulpitis
Vital Pulp Therapy to Treat Irreversible Pulpitis
The purpose of this study is to demonstrate non-inferiority of pulpotomy treatment (with new endodontic bio-materials) as a new treatment with one-visit root canal therapy as reference treatment in pain relief and clinical and…
- Trial name
- VPT (NCT00748280)
- Testing
- One-visit root canal therapy, pulpotomy
- Where
- Iran
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Dental Caries, Irreversible Pulpitis
Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irreversible Pulpitis
This study evaluates the effectiveness of photobiomodulation (PBM) in conjunction with mineral trioxide aggregate (MTA) pulpotomy for treating irreversible pulpitis in immature first permanent molars.
- Trial name
- NCT06730360
- Testing
- MTA Pulpotomy without photobiomodulation, MTA Pulpotomy with Photobiomodulation (LLLT)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Pulpitis
Comparison Between Reciproc and Oneshape Systems
A randomized clinical trial to assess postoperative pain in patients with symptomatic irreversible pulpitis after using Reciproc versus One Shape rotary NiTi Systems.
- Trial name
- NCT02940782
- Testing
- Reciproc single file system, One Shape single file system, X-smart Plus, Dentsply Maillefer, Ballaigues, Switzerland
- Volunteers
- 54 people
- Sponsor
- Cairo University
Pulp Disease, Dental
Evaluation of Different Materials in Pulpotomy of Primary Molars
The aim of the current study is to evaluate and compare clinical and radiographic success and antibacterial effect of Hyaluronic Acid and Amniotic membrane pulpotomy in primary molars in comparison with MTA pulpotomy (Randomized…
- Trial name
- NCT05981352
- Testing
- mineral trioxide aggregate pulpotomy, Dehydrated amniotic membrane pulpotomy, Hyaluronic acid pulpotomy
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Photobiomodulation, Endodontic Disease
Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery
The objective of this study will be to evaluate if photobiomodulation (FBM) can reduce postoperative pain in patients who will undergo endodontic surgery.
- Conditions
- Photobiomodulation, Endodontic Disease, Pain, Inflammation
- Trial name
- NCT05935306
- Testing
- Ibuprofen, Photobiomodulation simulation, Photobiomodulation
- Where
- Uruguay
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Pulpal Inflammation, Dental Caries
Effect of Different Heating Protocols of Resin Composites on Pulp Condition (Randomized Controlled Trial)
This randomized controlled clinical trial evaluates the effect of different resin composite preheating protocols on pulpal inflammation and postoperative pain.
- Conditions
- Pulpal Inflammation, Dental Caries, Postoperative Pain
- Trial name
- NCT07720999
- Testing
- Arm 1 only "VisCalor Thermoviscous Bulk-Fill Composite", Tetric EvoCeram Conventional Nanohybrid Composite (Preheated 55°C), Tetric EvoCeram Conventional Nanohybrid Composite (Room Temperature)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Pulp Disease, Dental
Sodiumhexametaphosphate as Pulp Capping Material for Primary Teeth
Sodiumhexametaphosphate will be tested as pulp capping material in comparison to MTA for primary teeth pulp therapy
- Trial name
- NCT06170775
- Testing
- Pulp therapy, Sodiumhexametaphosphate, MTA
- Volunteers
- 100 people
- Sponsor
- Minia University
Pulp Necroses
Laser Activated Irrigation Versus Passive Ultrasonic Irrigation
assessment of bacterial reduction and post-operative pain following Laser activated irrigation using sodium hypochlorite and a 980 nm diode laser device as an adjunct to conventional root canal treatment, and comparing it with…
- Trial name
- NCT04035083
- Testing
- Laser activated irrigation, Passive ultrasonic irrigation
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontically-Treated Teeth, Spacing of Anterior Maxillary Teeth
Assessment of Lateral and Vertical Tissue Displacement Obtained by the Retraction Cord and Diode Laser
In fixed prosthodontic treatment, deflection of gingival tissues for diagnosis or making an impression is one of the important phases.
- Conditions
- Endodontically-Treated Teeth, Spacing of Anterior Maxillary Teeth, Broken Teeth Injury With Complication
- Trial name
- NCT04258696
- Testing
- diode laser, ultrapak Knitted retraction cord
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Endodontically Treated Teeth, Endodontical Retreatment
Broken Instrument Removal
The aims of this retrospective analysis are (1) to evaluate the success rate of a non-surgical retreatment of teeth with broken file instrument into the canal using ultrasounds, microscope and a modified spinal needle, (2) to…
- Trial name
- NCT05128266
- Testing
- Endodontical Retreatment
- Volunteers
- 161 people
- Sponsor
- Catholic University of the Sacred Heart
Dental Pulp Diseases
Articaine Efficiency in Pulpectomy of Children With Irreversible Pulpitis Under the Age of Four
A two-tailed randomized controlled trial with two parallel arms is aimed to compare success proportions of the articaine and lidocaine groups in children with irreversible pulpitis under 4 years.
- Trial name
- NCT05944341
- Testing
- articaine hydrochloride 4% with epinephrine 1:100 000, Lidocaine hydrochloride 2% with epinephrine 1:100 000
- Where
- Egypt
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Minia University
Pulp Necrosis, Postoperative Pain
Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar.
The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.
- Trial name
- NCT07790796
- Testing
- Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Pulp Necrosis
Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth
the object of this study is to evaluate clinically and radiographically the effect of using Biodentine and Mineral Trioxide Aggregate as coronal plug materials in revascularization of non-vital immature teeth
- Trial name
- NCT03589560
- Testing
- Biodentine, Mineral Trioxide Aggregate
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontically Treated Teeth
Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 Expression
This clinical trial will be conducted to evaluate the amount of Il-8 expression before and after the application of intracanal irradiation with diode laser 980 nm versus placebo in failed endodontic cases with periapical lesions.
- Trial name
- NCT05603988
- Testing
- Intracanal Diode laser irradiation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain, Endodontically Treated Teeth
Effect of Different Final Irrigation Protocols on Postoperative Endodontic Pain in Devital Teeth
The purpose of this randomized clinical trial was to evaluate the incidence of postoperative pain after root canal treatment using different final irrigation protocols.
- Trial name
- NCT04310254
- Testing
- EDTA and CHX Solution, EDTA Solution, CHX Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital