Clinical trials: Pulmonary TB
Tuberculosis
Evaluation of Somatostatin Receptor Imaging Using PET/MRI as a Novel Approach to Detecting Pathology in Pulmonary TB
Imaging using 68Ga-DOTANOC PET (positron emission tomography) has the potential to detect granulomas in pulmonary tuberculosis, leading to previously unexplored indications for this PET tracer, including identification of…
- Trial name
- NCT02845570
- Testing
- 68Ga-DOTANOC PET/MRI, 18F-FDG PET/MRI
- Where
- 2 sites in Singapore
- Volunteers
- 8 people
- Sponsor
- National University Hospital, Singapore
Pulmonary Tuberculosis
Latency in Pulmonary Tuberculosis
The immune responses in latent tuberculosis are poorly understood. While it is difficult to define the onset of latency during natural infection, patients undergoing treatment for tuberculosis are driven into a state of latency…
- Trial name
- NCT01154959
- Testing
- Moxifloxacin, Isoniazid, Rifampicin Pyrazinamide, Ethambutol
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Tuberculosis Research Centre, India
Pulmonary Tuberculosis, Treatment Adherence
Effectiveness of Psychosocial Counseling in Patients With a New Tuberculosis Diagnosis
Introduction: Newly diagnosed TB patients frequently experience psychological distress, stigma, and concerns regarding treatment duration, side effects, and social consequences, which may negatively affect adherence.
- Conditions
- Pulmonary Tuberculosis, Treatment Adherence, Mental Health
- Trial name
- NCT07703696
- Testing
- psychosocial counseling
- Where
- Indonesia
- Volunteers
- 108 people
- Sponsor
- Universitas Diponegoro
Tuberculosis, Pulmonary
Safety and Efficacy of Ear Acupuncture for Antituberculosis Drug-Related Nausea and Vomiting
This study will look at whether press-needle ear acupuncture can help lower nausea and vomiting caused by antituberculosis medicines in people with pulmonary tuberculosis.
- Trial name
- NCT07271225
- Testing
- Press Needle
- Where
- Indonesia
- Volunteers
- 58 people
- Sponsor
- Universitas Indonesia
Tuberculosis, Tuberculosis, Pulmonary
Effect of Integrating Traditional Tuberculosis Care With Modern Health Care on Case Detection
Although many interventions are implemented to increase TB case detection, decrease diagnosis delay, and avoid catastrophic costs, there are no significant changes and the end TB goal will not be achieved in 2035.
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Tuberculosis Infection
- Trial name
- NCT05236452
- Testing
- Training for traditional and modern care providers
- Where
- Ethiopia
- Volunteers
- 918 people, healthy volunteers welcome
- Sponsor
- Bahir Dar University
Pulmonary Tuberculosis
A PAN-USR TB Multi-Center Trial
Tuberculosis (TB) remains a major public health issue and one of the top ten causes of death from a single infectious disease worldwide.
- Trial name
- NCT06905522
- Testing
- Bedaquiline (B), Sitafloxacin (S), Linezolid (L)
- Where
- 3 sites in China
- Volunteers
- 610 people
- Sponsor
- Shenzhen Third People's Hospital
Tuberculosis, Pulmonary
A Short Regimen for Rifampicin-resistant Isoniazid-susceptible TB
To assess outcome of treatment and safety among patients with rifampicin-resistant isoniazid-susceptible pulmonary tuberculosis treated with a novel regimen consisting of isoniazid, bedaquiline, and moxifloxacin throughout for 6…
- Trial name
- NCT06526039
- Testing
- a novel short regimen
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Pulmonary Tuberculosis
Evaluation of PTB Screening in ANC in Lusaka, Zambia
This is a pilot pulmonary TB screening program done in three antenatal care clinics in Lusaka, Zambia to determine the prevalence of culture-confirmed pulmonary tuberculosis and to determine the sensitivity and specificity of…
- Trial name
- NCT02053129
- Testing
- TB screening Questionnaire, Sputum smear and culture (only in HIV negative women who are symptomatic)
- Where
- Zambia
- Volunteers
- 5,033 people
- Sponsor
- University of North Carolina, Chapel Hill
Tuberculosis
To Evaluate the Safety, Tolerability, and Efficacy of TMC207 as Part of an Individualized Multi-drug Resistant Tuberculosis (MDR-TB) Treatment Regimen in Participants With Sputum Smear-positive Pulmonary MDR-TB.
The purpose of this study is to evaluate the safety, tolerability and effectiveness of TMC207 in combination with an individualized background regimen (BR) of antibacterial drugs as treatment for MDR-TB
- Trial name
- NCT00910871
- Testing
- TMC207, Background Regimen (BR) for MDR-TB
- Where
- 27 sites in China, Estonia and 10 more
- Volunteers
- 241 people
- Sponsor
- Janssen Infectious Diseases BVBA
Tuberculosis in HIV-infected Individuals, Drug Susceptible Pulmonary Tuberculosis
Short-Course Regimens for DS-PTB in AIDS Patients
This study adopts a multicenter, open-label, randomized controlled design, conducted across key designated AIDS diagnosis and treatment hospitals nationwide.
- Trial name
- NCT07608172
- Testing
- 2HPMZ/2HPM, 2HRZE/4HR
- Volunteers
- 148 people
- Sponsor
- Shanghai Public Health Clinical Center
Pulmonary TB
Phase 1 Clinical Trial of Single-Vial ID93 + GLA-SE in Healthy Adults
This is a phase 1, double-blind, randomized clinical trial to evaluate the safety, tolerability, and immunogenicity of single-vial lyophilized ID93 + GLA-SE compared to the two-vial presentation consisting of lyophilized ID93 and…
- Trial name
- NCT03722472
- Testing
- ID93 + GLA-SE
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Access to Advanced Health Institute (AAHI)
Drug-resistant Tuberculosis
Clinical Study of JDB0131 Benzenesulfonate Tablets in Patients With Drug-sensitive Pulmonary Tuberculosis
A randomized, open, drug controlled design of experiments was used to evaluate the early bactericidal activity, safety, tolerance and pharmacokinetic characteristics of JDB0131 benzenesulfonate tablet taken orally by drug…
- Trial name
- NCT06224036
- Testing
- JDB0131, Delamanid, Ethylpyrazine rifampicide (II)
- Where
- 2 sites in China
- Volunteers
- 52 people
- Sponsor
- Beijing Chest Hospital
Tuberculosis, Diagnosis
Identifcation of Biomarkers for Active Pulmonary Tuberculosis
This experiment is designed to analyze the metabolites in body fluids from patients with active tuberculosis and latent tuberculosis infection also with health volunteer, then combine the metabolic product features with clinical…
- Trial name
- NCT04490746
- Testing
- with no intervention, Collect samples
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Drug Susceptible Pulmonary Tuberculosis
Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary Tuberculosis
The purpose of this study is to evaluate if TBD09 in combination with other active agents in adults with drug sensitive pulmonary tuberculosis has potential to be safe and effective.
- Trial name
- NCT07525427
- Testing
- Bedaquiline, pretomanid and TBD09, Bedaquiline, pretomanid and linezolid
- Where
- 13 sites in South Africa
- Volunteers
- 150 people
- Sponsor
- Gates Medical Research Institute
TB, COVID-19
Evaluation of the Truenat™MTB Plus/COVID-19 Test for TB (Tuberculosis) and COVID-19 (SARS-CoV2)
This is a prospective, multicentre study in which the accuracy of the Molbio Diagnostics Truenat™ MTB (Mycobacterium tuberculosis) Plus/COVID-19multiplex will be assessed for TB and COVID-19 case detection using prospectively…
- Trial name
- Truenat COMBO (NCT05405296)
- Testing
- Truenat™ MTB Plus/COVID-19
- Where
- Uganda
- Volunteers
- 1,984 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Tuberculosis, Pulmonary, HIV Coinfection
Pharmacist-Led Intervention to Improve TB Treatment Adherence
The goal of this clinical trial is to compare the adherence of co-morbid patients in control and experimental group The main question[s]it aims to answer are: 1.
- Trial name
- RA-15041995 (NCT06608069)
- Testing
- Educational counselling
- Where
- 2 sites in Malaysia
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Primary Lung Tuberculosis
Early Retinal Nerve Fiber Layer Change of Ethambutol Optic Neuropathy by Optical Coherence Tomography
Ethambutol is widely used as first-line drug, but has serious side effect of optic neuropathy. As previously reported, incidence of ethambutol optic neuropathy is about 1~2%, there was considerable screening efforts and medical…
- Trial name
- NCT01866579
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Yonsei University
Pulmonary Tuberculosis
Effect of Vitamin D as Adjunctive Therapy in Patients With Pulmonary Evolution Tuberculosis
Tuberculosis (TB) is the second largest infectious disease that causes death in the last 4 centuries in all the world. Observational studies found an association between vitaminD and TB, suggesting a potential therapeutic role of…
- Trial name
- VitaminD (NCT02464683)
- Testing
- VitaminD
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Tuberculosis, Respiratory Tract Infections
Accuracy and Consequences of Using Trial-of-antibiotics for TB Diagnosis (ACT-TB Study)
This is a three-arm, open-label individually randomised controlled clinical trial investigating the benefits of the diagnostic use of broad-spectrum antimicrobials during the diagnostic process for tuberculosis (TB) and the risk…
- Conditions
- Tuberculosis, Respiratory Tract Infections, Pneumonia
- Trial name
- ACT-TB (NCT03545373)
- Testing
- Azithromycin, Amoxicillin
- Where
- Malawi
- Volunteers
- 1,583 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Lung Diseases, Tuberculosis
TB Contact Investigation: Behavioral Intervention
To develop a behavioral intervention aimed at public health workers who perform tuberculosis contact investigation and designed to enhance the contact investigation process.
- Trial name
- NCT00005740
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)