Clinical trials: Pulmonary Resection, open to volunteers
One-lung Ventilation (OLV), Video-assisted Thoracis Surgery (VATS)
Comparison of Different Ventilation Modes in Video-Assisted Thoracoscopic Lung Resection
One-lung ventilation (OLV) is required for video-assisted thoracoscopic surgery (VATS) lung resection, but it exposes the dependent lung to atelectasis, high driving pressures, and oxidative stress, and is associated with…
- Trial name
- OLV-VENT (NCT07866170)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Non-Small Cell Lung Cancer
Adjuvant EGFR-TKI Therapy After Surgery for EGFR-Mutant High-Risk Stage IA2-IIB NSCLC
This prospective, multicenter patient registry is designed to evaluate the effectiveness and safety of postoperative EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in patients with completely resected EGFR-mutant high-risk…
- Trial name
- NCT07837739
- Testing
- Adjuvant EGFR-TKI Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Lung Nodules
Bronchoscopic Navigation Robot-guided Dye Marking-assisted Thoracoscopic Pulmonary Nodule Resection
With the widespread use of low-dose spiral CT screening for the lungs, an increasing number of small nodules are being detected, and surgical resection is the preferred method for clinical intervention of pulmonary nodules.
- Trial name
- NCT06821451
- Testing
- Bronchoscopic navigation robot, Conventional electromagnetic navigation bronchoscope
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Ruijin Hospital
Non Small Cell Lung Cancer, Stage IIIA Lung Cancer
Neoadjuvant Treatment With Atezolizumab and Atezolizumab as Maintenance for the Treatment of Stage III Non Small-Cell Lung Cancer (NSCLC)
This is an open-label, phase II, multi-centre clinical trial. 97 Patients with stage IIIA and IIIB non-small cell lung cancer will be enrolled.
- Conditions
- Non Small Cell Lung Cancer, Stage IIIA Lung Cancer, Stage IIIB Lung Cancer
- Trial name
- ATHENEA (NCT07153445)
- Testing
- Atezolizumab, Paclitaxel, Carboplatin
- Where
- 21 sites in Spain
- Volunteers
- 97 people
- Sponsor
- Fundación GECP
Urinary Retention
Post-operative Urinary Retention (POUR) Following Thoracic Surgery
Inability to urinate a common complication that happens to many patients after a surgery, especially in men over 60 years of age who undergo surgery on their chest.
- Trial name
- POUR (NCT03609580)
- Testing
- Tamsulosin - 1 week, Tamsulosin - 3 days
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Lung Cancer (NSCLC), Lymph Node Dissection
Selective Lymph Node Resection for Invasive Non-small Cell Lung Cancer With the CTR of 0.5-1 and the Diameter of ≤ 2 cm
The study investigated the efficacy and safety of a selective lymph node strategy (no lower mediastinal lymph node dissection for upper lobe tumors and no upper mediastinal lymph node dissection for lower lobe tumors) in patients…
- Trial name
- NCT06634979
- Testing
- Selective lymph node dissection
- Where
- China
- Volunteers
- 684 people
- Sponsor
- Fudan University
Multiple Primary Lung Cancers
Video-Assisted Thoracoscopic Surgery Combined With Radiofrequency Ablation Versus VATS Alone for Multiple Primary Lung Cancer
This multicenter randomized controlled trial will compare two surgical approaches for patients with synchronous ipsilateral multiple primary lung cancer, meaning two or more primary lung cancers diagnosed at the same time in the…
- Trial name
- NCT07819669
- Testing
- Video-Assisted Thoracoscopic Resection of the Main Lesion, Intraoperative CT-Guided Radiofrequency Ablation of the Secondary Lesion, Video-Assisted Thoracoscopic Sublobar Resection of the Secondary Lesion
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Fibroadenoma, Breast Fibroadenoma
Management of Breast Fibroadenoma: Comparing Observation, Microwave Ablation, and Surgical Excision
The purpose of this study is to evaluate and compare three different management strategies for benign breast fibroadenoma: conservative management with clinical and radiological follow-up (observation), ultrasound-guided…
- Conditions
- Fibroadenoma, Breast Fibroadenoma, Benign Breast Disease
- Trial name
- NCT07890766
- Testing
- Ultrasound-guided percutaneous microwave ablation, Conventional open surgical excision
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Non-Small Cell Lung Cancer
Umbrella Trial of Adjuvant Therapy in Completely Resected High-risk Stage IA-IB NSCLC: Focus on Driver Mutations
This study explores how adjuvant therapy affects survival in completely resected high-risk stage IA-IB NSCLC patients with different driver gene mutations.
- Trial name
- UPLIFT (NCT06955325)
- Testing
- Icotinib, Rezivertinib, Ensartinib
- Volunteers
- 270 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Non-small Cell Lung Cancer Stage III
Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node or Other High Risk Features
The goal of this clinical trial is to learn about neoadjuvant cemiplimab with histology-specific chemotherapy followed by resection and adjuvant cemiplimab in stage 3 non-small cell lung cancer (NSCLC) with select N3 lymph node…
- Trial name
- NEO-SURG (NCT06449313)
- Testing
- Cemiplimab-Rwlc
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Georgetown University
COPD, ILD
SWEEP: Shuttle Walking Test for Exercise Evaluation in Pulmonary Resection
This is a prospective observational study that evaluates whether the Shuttle Walking Test (SWT) can predict postoperative symptoms, particularly dyspnea, in patients with chronic respiratory diseases undergoing lung resection.
- Conditions
- COPD, ILD, Bronchiectasis, Lung Cancer NOS
- Trial name
- SWEEP (NCT07102589)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Lung Cancer, Surgery
Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery
Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging.
- Conditions
- Lung Cancer, Surgery, Blood Pressure Management, Dexamethasone
- Trial name
- NCT04209218
- Testing
- Dexamethasone, Targeted blood pressure management, Routine blood presure management
- Where
- China
- Volunteers
- 1,988 people
- Sponsor
- Peking University First Hospital
Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules
Intraoperative Longitude-Latitude-Depth Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for 0.8-2 cm Peripheral Pulmonary Nodules
The goal of this clinical trial is to learn whether intraoperative longitude-latitude-depth three-dimensional localization (LLD localization) is non-inferior to preoperative CT-guided percutaneous lung puncture localization for…
- Conditions
- Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules, Pulmonary Nodules
- Trial name
- NCT07675889
- Testing
- Longitude-Latitude-Depth Localization, CT-Guided Percutaneous Lung Puncture Localization
- Where
- 4 sites in China
- Volunteers
- 274 people
- Sponsor
- Qilu Hospital of Shandong University
Lung, Lung Adenocarcinoma
Reinforced and Non-Reinforced Staple Lines in Fissureless Lobectomy
Prolonged Air Leak (PAL) is a common and serious problem after lung surgery. It can lead to worse patient outcomes, longer hospital stays, and higher costs.
- Conditions
- Lung, Lung Adenocarcinoma, Lung Adenosquamous Carcinoma, Lung Cancer, Non-Small Cell
- Trial name
- NCT06602661
- Testing
- Fissureless Lobectomy with Reinforced Staple Lines, Fissureless Lobectomy with Non-Reinforced Staple Lines
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Surrey Thoracic Surgery Group
Lung Cancer, Surgery
Neoadjuvant Intra-tumor Double Immunotherapy for Lung Cancer.
This phase II trial studies how well intra-tumor injection of double checkpoint inhibitors work when given alone and in combination with chemotherapy or/and bevacizumab in treating patients with previously untreated stage I-IIIA…
- Conditions
- Lung Cancer, Surgery, Non-small Cell Lung Cancer
- Trial name
- NCT06492421
- Testing
- ipilimumab, pembrolizumab, durvalumab, idarubicin, bevacizumab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Non-small Cell Lung Cancer (NSCLC)
Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)
The purpose of this phase 3 multicenter double-blind randomized study is to assess the use of taletrectinib in the early-stage non-small cell lung cancer (NSCLC).
- Trial name
- NCT07154706
- Testing
- Taletrectinib
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Nuvation Bio Inc.
NSCLC Stage IV
Primary Tumor Resection With EGFR TKI for Stage IV NSCLC
Our project is going to enroll patients with stage IV NSCLC with EGFR mutation and evaluate whether primary tumor resection after receiving the afatinib can prolong survival.
- Trial name
- NCT05215548
- Testing
- therapeutic thoracic surgery, Afatinib
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Non-small Cell Lung Carcinoma
Efficacy and Safety of Almonertinib Combined With or Without Chemotherapy as an Adjuvant Treatment for Stage II-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection
This is a multicenter, randomized, open label, phase III study.
- Trial name
- APEX (NCT04762459)
- Testing
- Almonertinib, Pemetrexed, Cisplatin
- Where
- 34 sites in China
- Volunteers
- 606 people
- Sponsor
- Chinese Academy of Medical Sciences
Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery.
- Conditions
- Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8
- Trial name
- NCT04267848
- Testing
- Biospecimen Collection, Carboplatin, Cisplatin
- Where
- 1,151 sites in United States, Guam
- Volunteers
- 1,210 people
- Sponsor
- National Cancer Institute (NCI)
Stage II-III Non-small Cell Lung Cancer
Real World Stage II-III NSCLC Patients Receiving Neoadjuvant Chemo-immunotherapy and no Surgical Resection
Neoadjuvant chemo-immunotherapy, with or without adjuvant immunotherapy, is currently the standard of care for resectable stage II-III NSCLC.
- Trial name
- NoSurgery (NCT07131163)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center