Clinical trials: Pulmonary Function
Breast Neoplasms, Radiation Pneumonia
Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort
Prospective cohort research to study the state of oxygen metabolism, reserve capabilities of cardiovascular and respiratory systems in patients with breast cancer to create a program of prevention and rehabilitation of lung…
- Conditions
- Breast Neoplasms, Radiation Pneumonia, Radiation Pneumonitis, Radiation Induced Fibrosis
- Trial name
- RELIEF-COHORT (NCT06069115)
- Testing
- Radiation therapy protocol for Breast cancer, Spirography and assessment of pulmonary diffusion capacity, Cardiopulmonary stress test
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Asthma
A New Modified-release Tablet Formulation of Prednisone (Lodotra®) in Patients With Nocturnal Asthma
The purpose of the study is to evaluate in subjects suffering from nocturnal asthma, the efficacy and safety of modified release Prednisone on signs and symptoms.
- Trial name
- MONA (NCT00686335)
- Testing
- Lodotra, Cortancyl
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Amgen
Lung Cancer
A Novel Lung Function Imaging Modality As a Preoperative Evaluation Tool (LIME)
To evaluate the correlation between pre-surgical 4DCT-ventilation imaging and post-surgical lung function.
- Trial name
- NCT03426306
- Testing
- 4DCT-Ventilation
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of Colorado, Denver
Depression, Heart Failure
Combined Illness Management and Psychotherapy in Treating Depressed Elders
The purpose of this research study is to test a program developed to help patients with chronic heart or lung problems take care of themselves and cope with their illness or limitations.
- Conditions
- Depression, Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- COPE (NCT01337726)
- Testing
- Combined Psychotherapy and Illness Management, Illness Management Only
- Where
- 2 sites in United States
- Volunteers
- 226 people
- Sponsor
- University of Iowa
Asthma, Cough Variant Asthma
Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly.
- Trial name
- NCT01064245
- Testing
- high-dose methacholine challenge test, mannitol challenge test
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Dr. Diane Lougheed
Tuberculosis, Post-Tuberculous Pleural Fibrosis
Endurance Training in Patients With Post-TB Lung Disease
To determine the effects of endurance training on functional capacity and QOL(Quality of life) in patients with post-TB (tuberculosis) lung disease. Post-tuberculosis lung disease is a major health concern nowadays.
- Conditions
- Tuberculosis, Post-Tuberculous Pleural Fibrosis, Post-Tuberculous Bronchiectasis
- Trial name
- NCT06047795
- Testing
- Experimental, Control
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease
A 12 Week Physical Training Programme for Patients With Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether water based or land based group training is more effective for people with COPD.
- Trial name
- NCT00744484
- Testing
- Training in water, Training on land
- Where
- Norway
- Volunteers
- 22 people
- Sponsor
- Norwegian University of Science and Technology
Non-Small Cell Lung Cancer, PET/CT
FAP-targeted PET/NIR in Lung Malignant Tumors
Single center, prospective, diagnostic study. Patients with stage II-IIIB resectable NSCLC diagnosed by pathology were included.
- Conditions
- Non-Small Cell Lung Cancer, PET/CT, Neoadjuvant Therapy
- Trial name
- NCT07498933
- Testing
- PET/CT scans
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Neuromuscular Diseases in Children
Mechanical Insufflator/Exsufflator Technique in Children With Neuromuscular Disease
In a randomized cross-over design, two different modes of a mechanical insufflator/exsufflator applied to pediatric subjects with neuromuscular disease will be compared with respect to their short term effect on lung function…
- Trial name
- MINEX-2 (NCT05454215)
- Testing
- Mechanical insufflation/exsufflation conventional, Mechanical insufflation/exsufflation modified
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
COPD, IPF
Functional MR Lung Imaging Using Hyperpolarised 129Xe
The aim of this study is to investigate the potential value of a novel imaging technique (hyperpolarized 129Xe lung imaging) in the diagnosis and assessment of lung disease in patients with COPD and IPF.
- Trial name
- NCT02976935
- Testing
- hyperpolarised 129 Xenon
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cystic Fibrosis
Do Musculoskeletal Techniques Improve Forced Expiratory Volume in One Second in Adults With Cystic Fibrosis?
The pilot study aims to evaluate the effects of a treatment series of gentle joint and muscle movements (in addition to normal optimal care)on lung function, exercise capacity and posture in stable adults with cystic fibrosis.
- Trial name
- NCT00716664
- Testing
- A treatment series of gentle joint and muscle movements, Control group measurements
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Blood Pressure, Lung Function
The Use of Air Cleaners to Mitigate Cardiopulmonary Health Impact of Indoor Exposure to Particles and Phthalates
This study aims to evaluate whether a short-term intervention strategy using air cleaner reduces indoor exposure to airborne particles (particulate matter with an aerodynamic diameter ≤2.5μm, PM2.5) and phthalates and improves…
- Conditions
- Blood Pressure, Lung Function, Inflammation, Oxidative Stress
- Trial name
- NCT03500614
- Testing
- Air cleaner use method 1, Air cleaner use method 2
- Where
- China
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Peking University
Airway Responsiveness
The Effect of Esomeprazole and Fundoplication on Airways
Evaluate the prevalence of bronchial responsiveness (BHR) among patients with gastroesophageal reflux disease (GERD). Investigate correlation between bronchial reactivity and the severity of GERD, and similarly investigate the…
- Trial name
- NCT00994708
- Testing
- esomeprazole
- Where
- Finland
- Sponsor
- Tampere University Hospital
Heart Failure, Pulmonary Hypertension
Exercise Training to Improve Cardiopulmonary Hemodynamics in Heart Failure Patients
This research study is being done to find out if exercise therapy can help improve the heart function, overall health, and quality of life of patients with pulmonary hypertension caused by heart failure.
- Trial name
- NCT04909008
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Lung Cancer, Exercise Capacity
Physical Functioning Throughout Lung Cancer Treatment
This trial investigates the impact of lung cancer treatment on physical status, symptoms and quality of life. Furthermore this trial investigates possible underlying causes and consequences of deconditioning.
- Conditions
- Lung Cancer, Exercise Capacity, Physical Activity, Quality of Life
- Trial name
- LUCAT (NCT02493114)
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hasselt University
NSCLC Diagnosed by Histology or Cytology, A Multidisciplinary Team Assessment Determined That the Patient Was a Suitable Candidate for Radical Surgical Resection
Phase II Clinical Study of Probiotic LR607 in Patients With Non-Small Cell Lung Cancer
The goal of this clinical trial is to understand whether Lactobacillus rhamnosus LR607 can enhance neoadjuvant chemoimmunotherapy for adult patients with non-small cell lung cancer. It will also evaluate the safety of LR607.
- Conditions
- NSCLC Diagnosed by Histology or Cytology, A Multidisciplinary Team Assessment Determined That the Patient Was a Suitable Candidate for Radical Surgical Resection, Overall Lung Function is Adequate for the Planned Lung Resection, AJCC is Classified as IB-IIIC
- Trial name
- NCT07534033
- Testing
- Probiotics combined with neoadjuvant chemoimmunotherapy
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease
Effect of add-on Doxofylline on Lung Function in Stable COPD
It is a phase IV, prospective, interventional, single blind, randomized, crossover trial in which the investigators will evaluate the effects of a 4-week treatment with doxofylline 400 mg bid, in add-on to maximal inhalation…
- Trial name
- EDAI (NCT04238221)
- Testing
- Doxofylline
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- University of Milan
Asthma
Study to Assess the Effect of Formoterol and Beclomethasone Dipropionate in Asthmatic Patients
The objective of this study is to evaluate the effect of the combination of formoterol and beclometasone dipropionate on central and peripheral airway dimensions in asthmatic patients using Computational Fluid Dynamics (CFD).
- Trial name
- NCT00910793
- Testing
- Inuvair
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Wilfried De Backer
Pulmonary Disease
p450 Mediated Lung Toxicity
The purpose of this project is to do cross species comparisons of the metabolism and toxicity of a number of toxicants which require metabolism for toxicity.
- Trial name
- NCT00023114
- Volunteers
- 10 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Acute Lung Injury(ALI)
Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery
This randomized controlled trial evaluated the dose-dependent effects of dexmedetomidine (DEX) on pulmonary function and aquaporin-1 (AQP1) expression during one-lung ventilation (OLV) in thoracoscopic surgery.
- Trial name
- NCT07145814
- Testing
- dexmedetomidine 0.3 µg/kg/h, dexmedetomidine 0.5 µg/kg/h, 0.9 % saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- People's Hospital of Guangxi Zhuang Autonomous Region