Clinical trials: Pulmonary Embolism (PE)
Venous Thromboembolic Disease, Deep Venous Thrombosis
Registry of Angiovac Procedures In Detail Outcomes Database-RAPID Registry
Venous thromboembolic disease is a significant cause of morbidity and mortality. The purpose of the RAPID registry is to collect information on the Angiovac procedure and Angiovac device used in the treatment of deep venous…
- Conditions
- Venous Thromboembolic Disease, Deep Venous Thrombosis, Right Heart Pathology, Pulmonary Embolism
- Trial name
- RAPID (NCT04414332)
- Testing
- Data collection only
- Volunteers
- 234 people
- Sponsor
- University of California, Los Angeles
Pulmonary Embolism, Deep Vein Thrombosis
Discharge ALERT: Quality Improvement Initiative
Brigham and Women's Hospital will coordinate a Quality Improvement Initiative at other hospitals that focuses on whether physician notification prior to discharge of high risk VTE patients will reduce the incidence of VTE after…
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Prophylaxis, Venous Thromboembolism
- Trial name
- Discharge (NCT00853463)
- Testing
- Alert
- Where
- 22 sites in United States
- Volunteers
- 2,515 people
- Sponsor
- Brigham and Women's Hospital
Renal Insufficiency
Venous Thromboembolism in Renally Impaired Patients and Direct Oral Anticoagulants
In renally impaired patients with acute venous thromboembolism (VTE), standard-of-care (SOC) anticoagulation, i.e. heparins-vitamin K antagonists (VKA), at therapeutic dosage is associated with an increased risk of thromboembolic…
- Trial name
- VERDICT (NCT02664155)
- Testing
- Apixaban, Rivaroxaban, Heparin
- Where
- 31 sites in France
- Volunteers
- 203 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pulmonary Embolism, Acute Pulmonary Embolism
CLEANer Aspiration for Pulmonary Embolism
To evaluate the safety and efficacy of the Cleaner™ Pro Thrombectomy System for aspiration thrombectomy in patients with acute pulmonary embolism (PE).
- Conditions
- Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism
- Trial name
- CLEAN-PE (NCT06189313)
- Testing
- Cleaner Pro Thrombectomy System
- Where
- 14 sites in United States
- Volunteers
- 125 people
- Sponsor
- Argon Medical Devices
Pulmonary Embolism (Diagnosis)
Adjust-Unlikely PE
The aim of this pilot study is to assess the feasibility of a larger study to determine the Adjust-Unlikely algorithm safety and efficiency for diagnosing PE. The pilot study objectives are to: 1.
- Trial name
- NCT05708794
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Dr. Kerstin de Wit
Pulmonary Embolism
Replication of the EINSTEIN-PE Anticoagulant Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04879407
- Testing
- Rivaroxaban, Warfarin
- Where
- United States
- Volunteers
- 98,947 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Embolism
PUlmonary REhabilitation in Patients Suffering From Post-PE Syndrome
This study is a multicenter, parallel, randomized waitlist-controlled trial that primarily focuses on the short-term benefit of outpatient pulmonary rehabilitation (PR) on patients after acute pulmonary embolism.
- Trial name
- PURE-PE (NCT04615130)
- Testing
- Rehabilitation
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University of Vienna
PE - Pulmonary Embolism, PE - Pulmonary Thromboembolism
FlowTriever All-Comer Registry for Patient Safety and Hemodynamics
To evaluate the safety and effectiveness of the FlowTriever System for use in the removal of emboli from the pulmonary arteries in the treatment of acute pulmonary embolism (PE).
- Trial name
- FLASH (NCT03761173)
- Testing
- FlowTriever System, Anticoagulation Agents
- Where
- 81 sites in United States, Austria and 7 more
- Volunteers
- 1,200 people
- Sponsor
- Inari Medical
Atrial Fibrillation, Deep Vein Thrombosis
An Observational Post-Authorization Safety Specialist Cohort Event Monitoring Study (SCEM) to Monitor the Safety and Utilization of Rivaroxaban (Xarelto®).
This study aims to evaluate the use of rivaroxaban and its short term safety when used by patients for the new indications of prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, treatment…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- ROSE (NCT01871194)
- Where
- United Kingdom
- Volunteers
- 3,400 people
- Sponsor
- Professor Saad Shakir
Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance
PERSEUS is an academic, investigator-initiated, multicenter observational registry of adults with acute pulmonary embolism (PE), promoted by Azienda Ospedaliero-Universitaria Careggi (Florence, Italy).
- Conditions
- Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension, Right Ventricular Dysfunction, Pulmonary Embolism (PE)
- Trial name
- PERSEUS (NCT07855679)
- Testing
- Routine clinical care (no study intervention)
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Pulmonary Embolism, Venous Thromboembolism
Supplemental Oxygen in Pulmonary Embolism (SO-PE)
A study of how supplemental oxygen helps patients with acute pulmonary embolism (PE). Hypothesis: Oxygen affects right ventricular dysfunction (RVD) in patients with acute pulmonary embolism (PE) primarily by relieving hypoxic…
- Conditions
- Pulmonary Embolism, Venous Thromboembolism, Metabolomics, Oxygen Inhalation Therapy
- Trial name
- SO-PE (NCT05891886)
- Testing
- Oxygen Therapy, Non-rebreather mask
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Pulmonary Embolism, Chronic Obstructive Pulmonary Disease
Pulmonary Embolism as a Cause of COPD Exacerbations
The primary objective is to demonstrate the clinical benefits of an active strategy for the diagnosis and treatment of PE compared to usual care in patients with unexplained exacerbations of COPD who require hospital admission.
- Trial name
- SLICE (NCT02238639)
- Testing
- Diagnostic and therapeutic strategy: Highly sensitive D-dimer testing and, if positive, multidetector computed tomographic pulmonary angiography (MDCT).
- Where
- 19 sites in Spain
- Volunteers
- 746 people
- Sponsor
- Ministry of Health, Spain
Pulmonary Embolism
Reperfusion Treatment in Acute Pulmonary Embolism
International guidelines recommend immediate reperfusion with systemic thrombolysis (ST) as first-line treatment in high-risk pulmonary embolism (PE).
- Trial name
- PE-NORDIC (NCT07003646)
- Testing
- Catheter directed intervention, any device, Alteplase
- Where
- 13 sites in Denmark, Sweden
- Volunteers
- 220 people
- Sponsor
- Sahlgrenska University Hospital
Pulmonary Embolism
Diagnostic Strategy for Suspected Pulmonary Embolism Based on 4PEPS
The increased use of diagnostic imaging and especially computed tomography pulmonary angiography in patients suspected of pulmonary embolism (PE) is an important point of concerns.
- Trial name
- SPEED&PEPS (NCT06015529)
- Testing
- 4PEPS strategy
- Where
- 23 sites in Belgium, France
- Volunteers
- 3,084 people
- Sponsor
- University Hospital, Angers