Clinical trials: Pulmonary Artery Pressure
Pulmonary Hypertension
Losartan Therapy in Pulmonary Hypertension
In addition to being effective vasodilators, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) exert neurohumoral inhibitory actions, such as the inhibition of vascular remodeling and…
- Trial name
- NCT00519870
- Testing
- nifedipine, losartan, losartan
- Sponsor
- Baskent University
Right Heart Catheterization
The Nanowear Wearable System SimpleSense Validation Trial for Cardiac Output
The Nanowear SimpleSense study is a single center, prospective, non-randomized, feasibility, non- significant risk study The study will be done in 2 phases.
- Trial name
- NCT05629533
- Testing
- SimpleSense
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Nanowear Inc.
Pulmonary Embolism
Catheter-Directed Pulmonary Reperfusion in Treatment of Pulmonary Embolism Patients
Primary objective: to evaluate the success and mortality rates of catheter-directed reperfusion therapy in comparison to traditional use of systemic intravenous fibrinolytic therapy, will focus at safety of such management…
- Trial name
- NCT04911192
- Testing
- mechanical fragmentation, In Situ thrombolysis
- Volunteers
- 60 people
- Sponsor
- Assiut University
Heart Failure, Chagas Disease
Effect of Ganglionar Electrical Stimulation on Central Arterial Pressure
This study will evaluate the applications of ganglionar electrical stimulation in patients with Chagas Disease and Ischemic Heart Failure patients.
- Trial name
- NCT01874795
- Testing
- TENS
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Heart Failure NYHA Class III
Effect of DASH Eating Pattern on Heart Failure Outcomes
The objective of the study is to examine the effect of nutritional intake on cardiometabolic, inflammation, and physical function markers in advanced heart failure patients using a one-group pre-post test design feeding trial.
- Trial name
- DASH HF (NCT03538990)
- Testing
- DASH Eating Pattern
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Georgia
Pulmonary Arterial Hypertension
Tezosentan in Patients With Pulmonary Arterial Hypertension
Multicenter, double-blind, randomized, placebo-controlled, cross-over study to demonstrate that a single infusion of tezosentan has minimal effect on blood pressure in patients with pulmonary arterial hypertension, treated with…
- Trial name
- NCT01094067
- Testing
- ACT-050089
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 2 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Healthy Volunteers, Chuvash Polycythaemia
Study of the Effects of Commercial Air Travel on the Lungs
The study hypothesis is that commercial air travel causes an increase in the blood pressure in the lungs (pulmonary artery pressure) that can be clinically relevant.
- Trial name
- NCT01420224
- Testing
- Commercial airline flight
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Septic Shock
Comparison of Manual PAOP and Automatic PAOP (Smart Wedge)
The pulmonary artery catheter (Swan-Ganz) is a standard tool in intensive care for measuring and monitoring the pulmonary artery occlusion pressure (PAOP).
- Trial name
- SMART-PAPO (NCT07703592)
- Testing
- Swan-Ganz IQ™, Smart Wedge
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Arterial Hypertension
A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
The primary objective of this study is to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in…
- Trial name
- ARTISAN (NCT05203510)
- Testing
- Parenteral Treprostinil, Oral Treprostinil
- Where
- 28 sites in United States
- Volunteers
- 52 people
- Sponsor
- United Therapeutics
Pulmonary Disease, Chronic Obstructive
Interest of a 30 Minutes' Intermittent Work Exercise Test in Patients With Chronic Obstructive Pulmonary Disease: Cardiac and Pulmonary Functions
The aim of the study is to observe the ventilatory and cardiac function (included the pulmonary arterial pressure) during an intermittent work exercise test with high density work load.
- Trial name
- NCT00295113
- Testing
- EFR
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Hypertension, Magnetic Resonance Imaging
4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension
Due to radiation exposure and low but real risk of morbidity and mortality associated with right heart catheterization, non-invasive procedures to estimate mPAP are desired for the diagnosis of PH or to monitor treatment…
- Conditions
- Pulmonary Hypertension, Magnetic Resonance Imaging, Pulmonary Arterial Pressure, Right Heart Catheterization
- Trial name
- HTPFLUW (NCT05103189)
- Testing
- 4D-flow sequence
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pulmonary Vascular Disorder, Pulmonary Artery Hypertension
HA Residents With PVD, Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) With and Without Supplemental Oxygen Therapy (SOT)
To study the effect of SOT in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH) who permanently live >2500m on pulmonary artery…
- Conditions
- Pulmonary Vascular Disorder, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06084559
- Testing
- Supplemental oxygen therapy
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Pulmonary Edema
Lung Ultrasound in High Altitude Lung Edema
High altitude pulmonary edema is a life-threatening condition that remains a concern for climbers and clinicians alike. It is defined as a non-cardiac pulmonary edema occurring at altitudes exceeding 3000m in non-acclimatised…
- Trial name
- NCT03117686
- Testing
- lung ultrasound
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obstructive Sleep Apnea of Adult
Assessment of Pulmonary Artery Pressure and Right Sided Hemodynamics in Patients With OSA Before and After CPAP TTT
Obstructive sleep apnea (OSA) is a frequent sleep-related breathing disorder with an incidence of 5-20% in the middle-aged population in Europe and Northern America .
- Trial name
- NCT03276611
- Testing
- echocardiograghy
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
One-Lung Ventilation, Thoracic Surgery
Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery
Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups.
- Trial name
- NCT06505772
- Testing
- Dexmedetomidine, Normal saline
- Where
- Syria
- Volunteers
- 78 people
- Sponsor
- Damascus University
Essential Hypertension
Physical Activity, Air Pollution, and High Blood Pressure
The investigators are investigating the effects of traffic-related air pollution (TRAP) on the cardiovascular and pulmonary response to exercise in patients with hypertension using a real world randomized, crossover study design.
- Trial name
- NCT05092672
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of British Columbia
Anaemia
Effects of GSK1278863A on Pulmonary Artery Pressure in Healthy Volunteers
This protocol is designed to explore whether short-term therapy with GSK1278863 affects PASP under normoxic and hypoxic conditions in healthy volunteers.
- Trial name
- NCT01673555
- Testing
- GSK1278863
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
LEVOSIMENDAN, PULMONARY THROMBOENDARTERECTOMY
The Effect of Levosimendan on Pulmonary Artery Pressure and Right Ventricular Function in the Perioperative Period in Patients With CTEPH After Pulmonary Thromboendarterectomy
A single-center pilot prospective randomized placebo-controlled double-blind clinical trial. Study objective - to investigate the efficacy and safety of levosimendan in patients in the perioperative period following pulmonary…
- Conditions
- LEVOSIMENDAN, PULMONARY THROMBOENDARTERECTOMY, Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Pulmonary Hypertension
- Trial name
- LEVO-CTEPH (NCT07914933)
- Testing
- Infusion of levosimendan
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Hypertension, Pulmonary
This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
In this trial the effects of the inhaled drug BAY1237592 will be studied in patients with high blood pressure in the pulmonary blood vessels due to Pulmonary Arterial Hypertension (PAH) and due to Chronic Thromboembolic Pulmonary…
- Trial name
- ATMOS (NCT03754660)
- Testing
- BAY1237592
- Where
- 8 sites in Austria, Czechia and 2 more
- Volunteers
- 38 people
- Sponsor
- Bayer