Clinical trials: Puberty
Hypogonadotropic Hypogonadism, Reproductive Disorder
The Molecular Basis of Inherited Reproductive Disorders
The goal of this study is to learn more about the genes that control puberty and reproduction in humans.
- Conditions
- Hypogonadotropic Hypogonadism, Reproductive Disorder, Kallmann Syndrome, Delayed Puberty
- Trial name
- NCT05971836
- Where
- United States
- Volunteers
- 854 people
- Sponsor
- Stephanie B. Seminara, MD
Precocious Puberty, Treatment
A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious Puberty
A randomized controlled study will be conducted to evaluate the therapeutic effect of traditional Chinese medicine and acupoints stimulation on children with idiopathic precocious puberty.
- Conditions
- Precocious Puberty, Treatment, Alternative Medicine, Acupuncture
- Trial name
- NCT06510764
- Testing
- intradermal needles, Ziyinxiehuo Granules of traditional Chinese Medicine
- Where
- 2 sites in China
- Volunteers
- 170 people
- Sponsor
- Children's Hospital of Fudan University
Overweight/Obesity, Puberty
Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks
This study is testing whether improving health in girls during the prepubertal period may slow the onset of puberty. This study will focus on prepubertal girls who have a high weight status (at or above the 85th percentile for…
- Conditions
- Overweight/Obesity, Puberty, Health Behavior, Cardiometabolic Health
- Trial name
- NCT07460544
- Testing
- Family-Based Treatment (FBT)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Washington
Attention-deficit/Hyperactivity Disorder, Constitutional Growth Delay
Prevalence of Attention Deficit Disorder Among Patients With Constitutional Growth Delay
The aim of the our study is to investigate whether there is an increased incidence of ADHD ( based on self reports and questionnaires) among children with short stature due to constitutional growth delay (CGD) in comparison with…
- Trial name
- NCT02329236
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Central Precocious Puberty
A Study of Leuprorelin 1-Month (4-Week) Formulation in Children With Central Precocious Puberty
A Single-Arm, Open-Label, Multicenter, Prospective Clinical Study to Evaluate the Effectiveness and Safety of Leuprorelin 1-Month (4-Week) Formulation Administered for 24 Months in Children with Central Precocious Puberty
- Trial name
- NCT07710430
- Testing
- Leuprorelin
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- LG Chem
Transgenderism, Insulin Sensitivity/Resistance
Puberty Suppression and Cardiometabolic Health
This observational study will evaluate the effect of puberty suppression on insulin sensitivity, metabolic rate and vascular health among transgender female youth at baseline and 6 months after initiation of a gondoatropin…
- Conditions
- Transgenderism, Insulin Sensitivity/Resistance, Endothelial Dysfunction, Vascular Stiffness
- Trial name
- NCT04482374
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Delayed Puberty, Precocious Puberty
Follicle-Stimulating Hormone (FSH) and the Onset of Puberty
The purpose of this study is to determine if the timing of the onset of puberty may be affected by FSH-regulatory peptides. We will determine how these peptides relate to FSH production in prepubertal and pubertal children by…
- Trial name
- NCT00734279
- Testing
- Leuprolide Acetate - Early Puberty Leuprolide Visit, Ganirelix - Early Puberty Ganirelix Visit, Ganirelix - Delayed Puberty Ganirelix Visit
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Utah
Primary or Secondary Hypogonadism, Constitutional Delay in Growth and Puberty (CDGP)
Observation Study of T-Gel (1%) in Treatment of Adolescent Boys With Hypogonadism
This study is to observe efficacy and safety after T-Gel 1% treatment in delayed puberty adolescents. Subjects who complete this trial may enter a 3 month extension study (UMD-01-090E).
- Trial name
- NCT00193661
- Testing
- Testosterone Gel (1%)
- Where
- 19 sites in United States
- Sponsor
- Solvay Pharmaceuticals
Adolescent Development, Stress
Neurophysiology, Estrogen, and Stress Exposure in the Emergence of Depression in Adolescent Girls
The prevalence of adolescent depression is steadily rising in the U.S., especially among adolescent girls. Currently 20% of adolescent girls experience major depression compared with 6% of boys (National Institute of Mental…
- Conditions
- Adolescent Development, Stress, Emotional Disturbances
- Trial name
- EVOLVE (NCT03450135)
- Testing
- Trier Social Stress Test, Emotional go/no-go task
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Puberty, Precocious
First Observatory of Precocious Puberty.
The age of puberty has fluctuated throughout history. Recent data shows an increase in the age of onset of puberty signs, in the United States but also in Europe.
- Trial name
- PAPPEL (NCT06263868)
- Where
- 23 sites in France
- Volunteers
- 3,360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Puberty Delayed
Pubertal Replacement In Boys Study Nebido and Testoviron Depot Treatment
In this prospective open clinical study, Pubertal Replacement in Boys Study (PRIBS), boys 14-16 years with delayed puberty in terms of slow pubertal progression, were randomized to SoC treatment with TE: Testostoviron depot® 75…
- Trial name
- NCT05417035
- Testing
- Nebido
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- NU-Hospital Organization, Sweden
Central Precocious Puberty
Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children
The goal of CPP-EDG 01 study is to assess possible genetic and/or environmental parameters which may influence the growth rate of children affected by precocious puberty.
- Trial name
- CPP-EDG 01 (NCT00438217)
- Testing
- Triptorelin (GnRH agonists), Leuprolide (GnRH agonists)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Central Precocious Puberty
Evaluate the Efficacy and Safety of DWJ108J
This study aims to evaluate the efficacy and safety of DWJ108J (Leuprorelin acetate 11.25 mg) in patients with central precocious puberty.
- Trial name
- NCT06025409
- Testing
- Leuprolide Acetate 11.25 MG/ML
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Pediatric Obesity, Puberty, Precocious
The Effect of Decaffeinated Green Tea Polyphenol Intake on the Risk of Precocious Puberty Among Obese Girls
In this study, 6-10 years old obese girls will be recruited to test the preventive effect of decaffeinated green tea polyphenols on the risk of precocious puberty by the random, placebo-control and single blind design.
- Trial name
- NCT03628937
- Testing
- Decaffeinated Green Tea Polyphenol
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Precocious Puberty, Central
Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate
Analysis of body mass index in Central Precocious Puberty patients treated with leuprolide acetate
- Trial name
- NCT02974270
- Testing
- Leuprolide
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Kyungpook National University Hospital
Congenital Adrenal Hyperplasia (CAH), Familial Male-Limited Precocious Puberty (FMPP)
Natural History Study of Patients With Excess Androgen
This study will evaluate and gather information in patients with genetic causes of too much androgen (male-like hormone) in order to better understand the effects of too much androgen and describe problems associated with it.
- Trial name
- NCT00250159
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cystic Fibrosis
Puberty in Girls Followed for Cystic Fibrosis
In the general population, age of puberty, and age of menarche in girls, are closely correlated with those of their mother. The severity of chronic disease has an impact on the stature, the weight gain and the onset of puberty…
- Trial name
- EPIMUCO (NCT02562911)
- Testing
- Data collection
- Where
- 7 sites in France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Toulouse
Musculoskeletal and Metabolic Crosstalk
Effect of Resistance Training on Musculoskeletal Endocrine Interactions
This project will evaluate the impact of resistance training on the synthesis and release of hormones and growth factors from the musculoskeletal system and the extent to which the communicative capacity influences glucose…
- Trial name
- COMB (NCT02040727)
- Testing
- Resistance Training, No Resistance Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Idiopathic Short Stature
A 4 Year Combination Therapy of Growth Hormone and (GnRH) Agonist in Children With a Short Predicted Height
Estrogens are responsible for the disappearance of growth cartilage in the long bones at the end of the pubertal growth spurt both in boys and in girls.
- Trial name
- ZomaTrip (NCT00840944)
- Testing
- somatropin, triptorelin
- Where
- 6 sites in Belgium
- Volunteers
- 44 people
- Sponsor
- Belgian Study Group for Pediatric Endocrinology
Puberty and Body Composition
Association Between Soy Based Formula in Infancy and Puberty
Background: Children in industrialized and developing countries have a higher tendency to present earlier signs of puberty. One hypothesis includes the hormonal effects of phytoestrogens found in soy products.
- Trial name
- NCT02908971
- Testing
- soy based formula at infancy
- Where
- Israel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center