Clinical trials: Puberty
Precocious Puberty, Early Puberty
Effect of Exogenous Growth Hormone on Ocular Findings
Body size and eye function play an essential role in adapting to the environment and human survival. Growth hormone is commonly recognized by its effect on the height of individuals; Although from an evolutionary perspective, the…
- Conditions
- Precocious Puberty, Early Puberty, Refraction Error
- Trial name
- NCT05338411
- Where
- 2 sites in Iran
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Hyperandrogenism
Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone
The purpose of this study is to determine whether sleep-wake changes of luteinizing hormone pulse frequency are different in early pubertal girls with high testosterone levels compared to early pubertal girls with normal…
- Trial name
- CRM005 (NCT00930007)
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Overweight, Leanness
The Effects of Puberty and Weight on Sugar Metabolism in Children
Our goal is to investigate how hormones that control blood sugar, hunger, and stomach emptying change with puberty and being overweight. These substances change with a meal.
- Conditions
- Overweight, Leanness, Adolescent
- Trial name
- NCT01718080
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Adolescent Depression
Adolescent Mood During Puberty and Testosterone
Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention…
- Trial name
- AMPT (NCT06072677)
- Testing
- Healthy Minds Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Precocious Puberty
Effect of Prevalence of BMI on Efficacy of Herbal Medicines in Girls' Sexual Precocity
Effect of Prevalence of Overweight and Obesity(Body Mass Index (BMI)) on Efficacy of herbal medicines(ZiYinXieHuo) in girls sexual Precocity
- Trial name
- NCT04665713
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Delayed Puberty, Precocious Puberty
Follicle-Stimulating Hormone (FSH) and the Onset of Puberty
The purpose of this study is to determine if the timing of the onset of puberty may be affected by FSH-regulatory peptides. We will determine how these peptides relate to FSH production in prepubertal and pubertal children by…
- Trial name
- NCT00734279
- Testing
- Leuprolide Acetate - Early Puberty Leuprolide Visit, Ganirelix - Early Puberty Ganirelix Visit, Ganirelix - Delayed Puberty Ganirelix Visit
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Utah
Gender Dysphoria in Children, Puberty
Skeletal Health and Bone Marrow Composition Among Youth
Children and adolescents experiencing gender dysphoria feel increased distress with the onset of puberty. Gender clinics treat these young adolescents by "blocking" puberty using gonadotropin-releasing hormone (GnRH) agonist…
- Conditions
- Gender Dysphoria in Children, Puberty, Bone Development
- Trial name
- NCT04203381
- Testing
- GnRH Agonist
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Amy DiVasta, MD
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Reproductive Physiological Phenomena
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group…
- Trial name
- NCT03286517
- Testing
- Kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany)
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ghulam Nabi
Varicocele, Scrotal Disorder
Testicular Growth During Puberty in Boys With and Without a Left-sided Varicocele
Prospective observational study. A varicocele is defined as a dilatation of the veins in the plexus pampiniformis in the testicles. Varicoceles are a diagnostic dilemma and a therapeutic challenge.
- Trial name
- NCT03540056
- Testing
- Ultrasound
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
HIV Infections
Natural History Study of HIV Acquired in Infancy or Childhood
Background: About 10,000 children in the United States have been living with HIV infection since birth. Little is known about the long-term effects of HIV infection and its treatment on the growth and development of these…
- Trial name
- NCT00924365
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Osteoporosis
Calcium and Bone Mass in Young Females
We originally suggested that calcium in the diet is important in determining the amount of bone (bone mass) that builds up in young adults. We are testing the effect of calcium on bone mass in 354 Caucasian (white) girls.
- Trial name
- NCT00000402
- Testing
- Calcium
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Puberty
Minipuberty of Infancy and the Timing of Pubertal Development in Adolescence: a Follow-up of the Infant Feeding and Early Development (IFED) Cohort
Background: Earlier puberty is associated with adverse health throughout a person s life. The average age when puberty begins has been declining over the past decades in girls, and may also be declining in boys.
- Trial name
- NCT05463120
- Where
- 2 sites in United States
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Rejection Sensitivity, Puberty
Rejection Sensitivity and Puberty in Mental Health Vulnerability to Social Media Experiences in Early Adolescent Girls
This longitudinal study is designed to test bidirectional relationships between preteen girls' mental health and social media experiences.
- Conditions
- Rejection Sensitivity, Puberty, Psychopathology
- Trial name
- NCT06777823
- Testing
- Social Rejection Task
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy
Mexican and African American Family Focus Groups on Puberty
Primary Objective: For focus groups of Mexican American and African-American girls and focus groups of their parents to explore factors that could enhance the conduct of a future study of puberty and body mass.
- Trial name
- NCT00528762
- Testing
- Focus Group
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Precocious Puberty
LH Response to GnRH Test in Prepubescent Girls Under 6 Years
The project aims to establish the normal LH and FSH response to a standardized GnRH dose in healthy girls below 6 years of age, and compares the normal GnRH response to the GnRH response in girls with early puberty development.
- Trial name
- NCT01944488
- Testing
- GnRH agonist
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Polycystic Ovary Syndrome, Hyperandrogenism
Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia
Polycystic ovary syndrome (PCOS) is a common disorder marked by hyperandrogenism, oligo-/anovulation, and subfertility. The precise causes of PCOS are unclear, but the pathophysiology involves complex genetic and environmental…
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Puberty
- Trial name
- DENND1A (NCT02611128)
- Testing
- Phenotype/genotype assessment
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Development
The Adrenal Contribution to Androgen Production in Girls During Puberty
In girls with elevated androgens the precise source of androgen excess throughout puberty and early adolescence has not been carefully examined.
- Trial name
- NCT01062568
- Testing
- Adrenocorticotropin, Dexamethasone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Early Puberty
the Association Between Obesity and Early Puberty
childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype.
- Trial name
- NCT04317014
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Disease Control and Prevention
Puberty
The COPENHAGEN Puberty Study
By clinical examinations and withdrawing of blood samples from a large number of healthy Danish children, this study will reveal if age of pubertal onset is declining.
- Trial name
- NCT01411527
- Where
- Denmark
- Volunteers
- 1,957 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet