Clinical trials: Psychology, Social
Renal Transplant Rejection, Induction Therapy
Induction in Sensitized Kidney Transplant Recipients Without Pre-existing Donor-specific antiboDies
Induction therapy decreases the rate of acute allograft rejection in kidney transplant recipients (KTRs) and is strongly recommended.
- Trial name
- INSTEAD (NCT05385432)
- Testing
- Rabbit Anti thymocyte globulin (rATG), Basiliximab
- Where
- France
- Volunteers
- 244 people
- Sponsor
- University Hospital, Tours
Kidney Transplantation
Randomized Trial of Induction Therapies in High Immunological Risk Kidney Transplant Recipients
The purpose of this research study is to find out the effects of adding B lymphocyte modulating agents in patients at risk for rejection receiving an anti-rejection (immunosuppressive) regimen of Thymoglobulin® induction with…
- Trial name
- NCT00782821
- Testing
- Rabbit Antithymocyte Globulin, Velcade, Rituxan
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Antibody-mediated Rejection, Humoral Rejection
Efficacy and Safety of Eculizumab for Treatment of Antibody-mediated Rejection Following Renal Transplantation
This is an open-label analysis that will compare eculizumab versus Plasmapheresis (PP) and Immunoglobulin (IVIg) for the treatment of antibody-mediated rejection (AMR) in renal transplant recipients.
- Trial name
- NCT01895127
- Testing
- Eculizumab, Immunoglobulin, Plasmapheresis
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Behavior
Handheld Mirror to Improve Child's Behavior During Dental Treatment
The purpose of this study is to determine whether a handheld mirror helps to reduce child behavior problems during dental treatment. It will be tested by randomized crossover design.
- Trial name
- NCT02366520
- Testing
- handheld mirror
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Renal Transplant Rejection
Imaging Kidney Transplant Rejection Using Ferumoxytol-Enhanced Magnetic Resonance
The goal of this study is to develop a non-invasive imaging test for in vivo detection of kidney transplant rejection. The hypotheses are that 1) Ferumoxytol-MRI can generate accurate estimates of tissue iron concentrations and…
- Trial name
- NCT02006108
- Testing
- Feraheme, MRI-GE Healthcare 3 Tesla magnet
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Stanford University
End-Stage Renal Disease, Kidney Failure
Eculizumab for Prevention and Treatment of Kidney Graft Reperfusion Injury
Study of eculizumab ability to correct the reperfusion injury of the kidney allograft.
- Conditions
- End-Stage Renal Disease, Kidney Failure, Graft Reperfusion Injury
- Trial name
- NCT01756508
- Testing
- eculizumab
- Where
- Russia
- Volunteers
- 57 people
- Sponsor
- Russian Academy of Medical Sciences
Type2 Diabetes Mellitus, Cardiovascular Diseases
Mil Familias Cohort Establishment: a Study to Understand Determinants of Diabetes and Its Complications Among US Latinos
The Mil Familias Cohort Establishment involves enrolling 1000 Latino families with at least one member in the family having type 2 diabetes, including children and youth, and measuring the 5 determinants of human health…
- Trial name
- NCT03830840
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Breast Cancer
Facilitate and Sustain Return to Work After Breast Cancer
Breast cancer is the most frequent cancer in women in France, with an estimated 50,000 new cases each year. Prognosis is good, with a standardized survival rate of 85% at 5 years from diagnosis.
- Trial name
- FASTRACS-RCT (NCT04846972)
- Testing
- FASTRACS intervention
- Where
- 11 sites in France
- Volunteers
- 420 people
- Sponsor
- Hospices Civils de Lyon
Rejection, Lung Transplantation
Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation
In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.
- Trial name
- NCT00558597
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Liver Transplant; Complications, Liver Transplant Rejection
Mortality, Morbidity and Risk Factors of Liver Retransplantation
This study aims to compare the short and long term outcomes of living donor and deceased donor liver retransplantation. Bearing that in mind, the investigators will retrospectively analyze the files of patients whom underwent a…
- Conditions
- Liver Transplant; Complications, Liver Transplant Rejection, Liver Transplant Failure, Liver Diseases
- Trial name
- NCT04789213
- Testing
- Liver Transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Memorial Bahçelievler Hospital
Allosensitization, Heart Transplant Failure and Rejection
Daratumumab-SC for Highly Sensitized Patients Awaiting Heart Transplantation
The purpose of this study is to test whether Daratumumab-SC, a drug that eliminates antibody-producing plasma cells, can effectively lower the level of preformed antibodies in patients awaiting heart transplantation.
- Trial name
- NCT04610320
- Testing
- Daratumumab-SC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Ronald Witteles
Kidney Transplant Failure and Rejection
Prospective Assessment of Rejection in Kidney Transplant (PARK)
The PARK study is a multi-center observational study to assess the performance of the QSant test with kidney biopsy. QSant is a test based on 6 urinary biomarkers that is used for the evaluation and management of acute rejection…
- Trial name
- PARK (NCT05715853)
- Testing
- QSant
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- NephroSant
Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology
Trial of the Youth Readiness Intervention
The research will first examine data obtained from YRI participants to investigate effects of the group sessions on psychosocial and functioning outcomes in youth.
- Conditions
- Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology, Social Problems/Psychology, Stress, Psychological
- Trial name
- YRI (NCT01684488)
- Testing
- YRI, EducAid educational programming
- Where
- Sierra Leone
- Volunteers
- 443 people
- Sponsor
- Boston College
Liver Transplant Rejection
Graft Rejection or Tolerance Affected by Serial Change of Anti-donor Lymphocyte Antibody After Liver Transplantation
Liver is an organ that is well-known for its immune tolerant capacity. However, there were still controversial issues about the impact of immunologic challenge after liver transplantation on the graft function.
- Trial name
- NCT01444079
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yonsei University
BK Viremia, Kidney Transplant Infection
A Trial to Treat Polyomavirus Infections (BKPyV) in Kidney and Simultaneous Kidney Pancreas Transplant Recipients
BEAT-BK will see the effect of immunosuppression reduction/modification with and without IVIG on BKPyV infection, allograft function, allograft loss, acute transplant rejection, immunosuppression load and death in kidney and…
- Conditions
- BK Viremia, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- BEAT-BK (NCT05325008)
- Testing
- Immunosuppression reduction/modification + intravenous immunoglobulin, Immunosuppression reduction/modification
- Where
- 13 sites in Australia
- Volunteers
- 280 people
- Sponsor
- The University of Queensland
Kidney Transplant Rejection
Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
This is a randomized, open-label, controlled clinical trial designed to compare clinical outcomes after kidney transplantation using extended-release tacrolimus (Envarsus XR) versus immediate tacrolimus among highly-sensitized…
- Trial name
- NCT04225988
- Testing
- Extended-release tacrolimus, Immediate-release tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Kidney Transplant Failure and Rejection
BIOtechnology Applied to Renal TRansplantation With IMmunobiogram
Immunobiogram (IMBG) is a novel in vitro diagnostic bioassay developed by Biohope Scientific Solutions for Human Health SL, that allows to measure the pharmacodynamic response to individual immunosuppressive drugs in patients…
- Trial name
- BIOTRAIM (NCT05816486)
- Testing
- Immunobiogram
- Where
- 15 sites in Brazil, France and 3 more
- Volunteers
- 443 people
- Sponsor
- Biohope Scientific Solutions for Human Health, S.L.
Lung Transplant, End Stage Lung Disease
GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation
Background: Lung transplants can save lives, but the procedure has risks. Some people develop donor-specific antibodies (DSA) after the procedure-that is, their bodies create proteins that treat the new lungs as foreign and mount…
- Conditions
- Lung Transplant, End Stage Lung Disease, Rejection
- Trial name
- NCT07516379
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Liver Disease
Role of Tissue C4d in Differentiation Between Acut e Rejection and HCV Recurrence After Liver Transplantation
Assessment of the role of tissue C4d complement fragments in liver biopsy as a new marker for differentiating between acute rejection and Hepatitis C (HCV) recurrence in recipients post living donor liver transplantation (LDLT)…
- Trial name
- NCT02209675
- Testing
- liver biopsy
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Ain Shams University
Kidney Transplant Failure and Rejection
Anti-Angiotensin II Type 1 Receptor Antibodies and Kidney Transplant Outcomes
Incompatibility between non-genetically identical donors and recipients has been increasingly recognized as the main contributing factor to solid allograft rejection and failure, through the triggering of donor-specific responses…
- Trial name
- NCT03466775
- Testing
- Anti-angiotensin II type 1 receptor antibody measurement, Measurement of ENDAT expression level allograft, Allograft survival
- Where
- 2 sites in France
- Volunteers
- 1,845 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation