Clinical trials: Psychological Distress
Alcohol Use Disorder, Drug Use
A Hybrid Effectiveness Implementation Study of Latino/a Alcohol and Drug Users
Alcohol use is a significant problem among Latinxs and immigration-related stress increases risk for substance use. A theoretically-based cultural adaptation of motivational interviewing (CAMI) that specifically integrated…
- Conditions
- Alcohol Use Disorder, Drug Use, Psychological Distress
- Trial name
- CAMI-HI (NCT04771650)
- Testing
- CAMI
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Youth Mental Health, Psychological Distress in Adolescents and Young Adults
VIPeerAgent for Adolescent Mental Health
This three-arm parallel randomized controlled trial aims to evaluate the effectiveness of VIPeerAgent, a virtual peer support agent, in improving mental health outcomes among adolescents and young adults aged 14-25 years…
- Conditions
- Youth Mental Health, Psychological Distress in Adolescents and Young Adults, Early Intervention
- Trial name
- NCT07778758
- Testing
- Virtual Peer Agent Intervention, Human peer mentor
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-sen University
Psychological Distress, Insomnia
Clinical Trial for Acupuncture in Adolescents With Psychological Distress and Insomnia
This is an assessor-blinded, randomized, MAS-controlled trial. A total of 148 adolescents aged 15-22 years experiencing mild to moderate anxiety or depressive symptoms will be recruited.
- Trial name
- NCT06638450
- Testing
- Dense Cranial Electroacupuncture Stimulation plus Body Acupuncture (DCEAS+BA), Minimal Acupuncture Stimulation (MAS)
- Where
- Hong Kong
- Volunteers
- 148 people
- Sponsor
- The University of Hong Kong
Pancreas Cancer, Biliary Tract Cancer
Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers
The primary objective of this study is to evaluate the ability to recruit and retain participants, and to successfully conduct a psilocybin-based protocol, for a study of the treatment of distress related to stage IV or…
- Conditions
- Pancreas Cancer, Biliary Tract Cancer, Psychological Distress, Gastrointestinal Cancer
- Trial name
- NCT05220046
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Nebraska
Well-Being, Psychological, Dissociation
An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers
The proposed study will collect novel data evaluating the feasibility of the NFB training program delivered in an outpatient mental health setting and its influence on mothers' overall sense of well-being, and further investigate…
- Conditions
- Well-Being, Psychological, Dissociation, Maternal Care Patterns, Maternal Behavior
- Trial name
- NCT06054412
- Testing
- Neuroptimal (Zengar, Inc.) Neurofeedback
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wayne State University
Post Traumatic Stress Symptoms, Psychological Distress
Effectiveness of Cognitive Behavioral Intervention for Trauma in Schools (CBITS): A Study With Pakistani Adolescents
This study will evaluate whether a school-based counseling program, Cognitive Behavioral Intervention for Trauma in Schools (CBITS), helps reduce trauma-related symptoms and improve psychological functioning in adolescents in…
- Conditions
- Post Traumatic Stress Symptoms, Psychological Distress, Trauma Exposure
- Trial name
- NCT07768540
- Testing
- cognitive behavioral intervention for trauma in schools
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University of Modern Languages
Mental Health, HIV
"Gwan Enjoy Life:" A Peer-Supported Mental Health Mentoring Intervention to Improve Engagement in Care Among Sexual Minority Men Living With HIV in Jamaica
Sexual minority men (SMM) in Jamaica face many challenges that affect their health and well-being. Although they make up a relatively small part of the population, they are much more likely to be living with HIV than the general…
- Conditions
- Mental Health, HIV, Pyschological Distress, Suicidal Ideation
- Trial name
- GwanEnjoyLife (NCT07762612)
- Testing
- Gwan Enjoy Life Interveniton
- Where
- Jamaica
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Domestic Violence, Child Development
Musical Group Intervention for Children in Shelters
The aim of the study is to augment knowledge on interventions for children who live, or have lived, in shelters after exposure to domestic violence.
- Conditions
- Domestic Violence, Child Development, Psychological Distress, Music Therapy
- Trial name
- NCT05755178
- Testing
- Music, feelings and relationships - music group for children at shelters
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Kronoberg County Council
Gut Microbiota, Psychological Distress
Effects of Grape Powder on Psychological Distress and Gut Microbiota in College Students
The goal of this trial is to investigate the effect of freeze-dried table grape powder (FTGP) on psychological distress and gut microbiota in college students.
- Trial name
- NCT07214428
- Testing
- freeze-dried table grape powder
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Psychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders
Exposure Therapy for Reactivity to Symptoms
It is unclear to what degree systematic exposure exercises contribute to the overall effects of exposure therapy (exposure and response prevention).
- Conditions
- Psychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders, Bodily Distress Disorder
- Trial name
- SOMEX2 (NCT07757854)
- Testing
- Planned, systematic, exposure exercises, Response prevention
- Where
- Sweden
- Volunteers
- 360 people
- Sponsor
- Region Stockholm
Psychological Distress, Emotional Regulation
Impact of Mindful Self-Compassion Therapy on Self Harm Behaviors, Emotional Regulation and Quality of Life Among Patients With Borderline Personality Disorder
The primary purpose of the study is to investigate whether Mindful Self-Compassion (MSC) therapy can significantly reduce self-harm behaviors, improve emotional regulation, and enhance the quality of life in individuals diagnosed…
- Conditions
- Psychological Distress, Emotional Regulation, Self Harm, Quality of Life (QOL)
- Trial name
- NCT06699732
- Testing
- Mindful Self Compassion Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 70 people
- Sponsor
- Fatima Jinnah Women University
Cancer Survivorship, Psychological Distress
Bridging the Gap in Psychosocial Care for Cancer Survivors
The study aims to assess the feasibility and acceptability of the implementation of a routine digital psychosocial screening combined with a psycho-oncological Navigation Call for cancer survivors after completion of primary…
- Conditions
- Cancer Survivorship, Psychological Distress, Psycho-Oncology, Supportive Care
- Trial name
- BRIDGE (NCT07672314)
- Testing
- Navigation Call
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Cancer, Psychological Distress
Support and Healing Intervention for Adolescents With a Parent Diagnosed With Cancer (SHINE)
e purpose of this study is to develop and evaluate SHINE (Support and Healing Intervention for Navigating Parental Cancer Experiences), a family-centered program designed to support adolescents whose parent has been diagnosed…
- Conditions
- Cancer, Psychological Distress, Adaptation, Psychological
- Trial name
- SHINE (NCT07751185)
- Testing
- SHINE Psychosocial Intervention, Usual Supportive Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas Southwestern Medical Center
Pelvic Floor Disorder, Loneliness
Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial
The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth.
- Conditions
- Pelvic Floor Disorder, Loneliness, Postpartum, Mental Health
- Trial name
- PEARL (NCT07223736)
- Testing
- Generative artificial intelligence (genAI) postpartum chatbot, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Serious Illness, Distress, Emotional
AI-DBT For Serious Illness
Lay / General Audience Summary Many older adults living with serious illnesses experience high levels of emotional distress, including anxiety, sadness, fear, and feeling overwhelmed.
- Conditions
- Serious Illness, Distress, Emotional, Distress
- Trial name
- NCT07748312
- Testing
- AI DBT
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Depressive Symptoms, Depression, Anxiety
Transcranial Magnetic Stimulation for Psychological Distress in Patients With Advanced Illness
Psychological and existential distress are a common cause of suffering among patients nearing the end of life, and a major reason for requesting medical aid in dying.
- Conditions
- Depressive Symptoms, Depression, Anxiety, Psychological Distress, Terminal Illness
- Trial name
- NCT04257227
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Ottawa Hospital Research Institute
Suicide Crisis Syndrome, Psychological Distress
Psychopharmacological Treatment of Emotional Distress
This is an inpatient four-arm randomized control trial comparing single drug clonazepam (S arm), a two-drug combination clonazepam/olanzapine (D arm), and a three-drug combination clonazepam/olanzapine/buprenorphine (T arm) with…
- Trial name
- NCT06133114
- Testing
- Clonazepam, Olanzapine, Buprenorphine
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Quality of Life, Psychological Distress
Impact of a Climate-Adapted Self-Management Intervention for Hypertension: A Randomized Controlled Trial Examining Psychosocial and Environmental Determinants
This study aims to evaluate the effectiveness of a Climate-Adapted Self-Management Intervention in improving the quality of life among adults with hypertension.
- Conditions
- Quality of Life, Psychological Distress, Climate Change Anxiety, Health Behaviors
- Trial name
- NCT07720752
- Testing
- Climate-Adapted Self-Management Intervention
- Where
- 3 sites in Pakistan
- Volunteers
- 44 people
- Sponsor
- Fatima Jinnah Women University
Posttraumatic Stress Disorder (PTSD), Trauma and Stressor Related Disorders
EMDR Group Therapy for Posttraumatic Stress Symptoms in Migrants
The goal of this randomized controlled trial is to evaluate the effectiveness and feasibility of the Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol for Ongoing Traumatic Stress (EMDR-IGTP-OTS)…
- Conditions
- Posttraumatic Stress Disorder (PTSD), Trauma and Stressor Related Disorders, Psychological Distress
- Trial name
- NCT07731906
- Testing
- Integrative Group Treatment Protocol for Ongoing Traumatic Stress (EMDR-IGTP-OTS)
- Where
- Italy
- Volunteers
- 185 people
- Sponsor
- Azienda Sanitaria Locale Salerno
Neoplasm, Cancer
Digital Psychoeducational Intervention for Young Adults With Fertility Related Distress Following Cancer Diagnosis
The goal of this randomized controlled trial is to evaluate the effectiveness of a digital psychoeducational intervention for young adults experiencing fertility-related distress following a cancer diagnosis.
- Conditions
- Neoplasm, Cancer, Psychoeducational Intervention, Young Adults
- Trial name
- NCT07729696
- Testing
- Digital psychoeducational intervention
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Gadjah Mada University