Clinical trials: Psychological
Anterior Ischemic Optic Neuropathy
PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
The primary objective of this study is to determine whether the use of PDE5 inhibitors (vardenafil, sildenafil, or tadalafil) increases the risk for the development of NAION.
- Trial name
- NCT00867815
- Testing
- Diagnostic procedures
- Where
- 13 sites in United States, Australia and 1 more
- Volunteers
- 10 people
- Sponsor
- Bayer
Stress, Psychological
OUR Stress/ Emotion Management for Black/African American Women With Hypertension
Covid-19 is an additional stressor Black women have to deal with that may interfere with hypertension self-care management. Social connectedness is a source of resilience for Black women to promote mental and physical health.
- Trial name
- OUR-Project (NCT04526145)
- Testing
- Stress and emotion management
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ohio State University
End Stage Kidney Disease (ESRD), Hemodialysis
Hand Reflexology for Fatigue and Anxiety in Hemodialysis Patients
This randomized controlled trial evaluates the efficacy of hand reflexology massage (HRM) in reducing fatigue and anxiety among adult patients receiving maintenance hemodialysis.
- Conditions
- End Stage Kidney Disease (ESRD), Hemodialysis, Anxiety, Fatigue
- Trial name
- NCT07253831
- Testing
- Hand Reflexology Massage, Standard
- Where
- Iraq
- Volunteers
- 70 people
- Sponsor
- Kufa University
Depressive Symptoms, Stress, Psychological
Mobile Web-based Behavioral Intervention for Improving Caregiver Well-being
Caregivers suffer great amounts of distress that significantly impacts their mental and physical well-being, yet caregivers' access to quality, evidence-based care is currently very limited.
- Trial name
- NCT03506945
- Testing
- mPEP, Bibliotherapy
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Mental Health
Computerized Assessment and Referral System Screener for Mental Health Evaluations in the Emergency Setting
This is a hybrid effectiveness-implementation randomized controlled trial which will be conducted at the emergency department (ED) at the University of Arkansas for Medical Sciences (UAMS) in Little Rock, Arkansas.
- Trial name
- CARS-SA (NCT03323853)
- Testing
- Computerized Assessment and Referral System (CARS) Self-Assessment Screener, CARS-SA Summary Results
- Where
- United States
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Major Depressive Disorder
VA Augmentation and Switching Treatments for Improving Depression Outcomes
The overall purpose is to determine research based 'next-steps' for outpatients with major depressive disorder who have not had satisfactory outcomes to standard 'first-step' treatments.
- Trial name
- VAST-D (NCT01421342)
- Testing
- Switching: Bupropion-SR, Augmenting: Antidepressant + Bupropion-SR, Augmenting: Antidepressant + Aripiprazole
- Where
- 35 sites in United States
- Volunteers
- 1,522 people
- Sponsor
- VA Office of Research and Development
Alzheimer Disease, Dementia
Efficacy of Gamification in Enhancing User Engagement
As part of Phase II of the NIH SBIR grant, the study will conduct a randomized controlled clinical trial in which the MapHabit system's gamification is investigated to determine whether the assistive technology facilitates user…
- Conditions
- Alzheimer Disease, Dementia, Gamification, Assistive Technology
- Trial name
- NCT05422339
- Testing
- The MapHabit system (MHS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- MapHabit, Inc.
Sexual Dysfunctions, Psychological
Pharmacokinetics of Flibanserin in Postmenopausal Women With Hypoactive Sexual Desire Disorder (HSDD)
This trial examines the way flibanserin is metabolized in postmenopausal women with Hypoactive Sexual Desire Disorder.
- Trial name
- NCT01188603
- Testing
- flibanserin 100 mg dose every evening
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- Sprout Pharmaceuticals, Inc
Resilience, Psychological, Advance Care Planning
Facilitating Advance Care Planning Discussions for People With Advanced Cancer
The aims of this study are to (1) identify the advance care planning deliberation process among 20 dyads of patients with advanced cancer and family caregivers and (2) conduct usability testing among 9 dyads to refine the content…
- Trial name
- NCT06061965
- Testing
- Web-based resilience-building intervention
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Illinois Chicago
Dementia
Safety and Efficacy of Electroconvulsive Therapy (ECT) for Behavioural and Psychological Symptoms of Dementia (BPSD)
This is a prospective, open-label, observational study of the efficacy and safety of ECT for BPSD. There is no control or comparison group.
- Trial name
- ECTBPSD (NCT02969499)
- Where
- 3 sites in Canada
- Volunteers
- 33 people
- Sponsor
- University of British Columbia
Acute Coronary Syndrome, TIA
Early Psychological Intervention to Prevent Cardiovascular Event-Induced PTSD (REACH Sub-study)
The overall purpose of this project is to determine the feasibility of conducting a randomized clinical trial that compares written exposure therapy with usual care among patients at risk for cardiovascular event-induced PTSD.
- Conditions
- Acute Coronary Syndrome, TIA, Stroke, Cardiac Arrest
- Trial name
- NCT03605693
- Testing
- Written Exposure Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Erectile Dysfunction
Low Intensity Shockwaves Therapy for the Treatment of Erectile Dysfunction. 12- Month Follow-Up
The purpose of this study is to evaluate the safety and effectiveness of the shockwave therapy to treat Erectile Dysfunction.
- Trial name
- NCT03670628
- Testing
- Shockwave therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Miami
Endometriosis
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain
The primary objective of this extension study is to assess the maintenance of efficacy of linzagolix administered orally once daily for up to an additional 6 months (for up to 12 months of treatment in total) in women who have…
- Trial name
- EDELWEISS 5 (NCT04372121)
- Testing
- 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg)
- Where
- 25 sites in United States, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Mental Health
Patient Centered Enhancements in School Behavioral Health
This study will evaluate whether the evidence-based Wellness framework paired with an evidence-based Partnership compared to Wellness alone will improve middle school students\' social, emotional/behavioral, and academic…
- Trial name
- PSW (NCT03901274)
- Testing
- Wellness, Partnership
- Where
- 3 sites in United States
- Volunteers
- 2,558 people
- Sponsor
- University of South Carolina
Mental Health, Neurology
Implementing Evidence in the Detection and Treatment of Post Stroke Depression
Post Stroke Depression (PSD)is a high volume condition with negative impact on patient recovery after stroke. The primary aim of this study is to evaluate the effectiveness of a system intervention to improve the proportion of…
- Conditions
- Mental Health, Neurology, Health Services
- Trial name
- NCT00296140
- Testing
- self management of PSD symptoms, screening and treatment of PSD
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Burnout, Student, Alcohol; Harmful Use
Summative Assessment of the BurntOut 3D Simulation With Medical Students
Burnout is a common problem for medical students and is associated with stress-related health problems and also potentially affects the quality of care delivered to their patients.
- Conditions
- Burnout, Student, Alcohol; Harmful Use, Quality of Life, Depression
- Trial name
- NCT04494633
- Testing
- Clinical Encounters Medical School 3D Simulation
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Clinical Tools, Inc.
Caloric Restriction, Exercise
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
The objective of this study is to determine whether maintaining a eugonadal state, during severe, sustained energy deficit, attenuates physiological decrements, particularly the loss of lean body mass.
- Trial name
- OPS (NCT02734238)
- Testing
- Sesame Oil, testosterone enanthate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Diabetes Mellitus, Type 2, Housing Problems
Diabetes Homeless Medication Support
This randomized pilot trial of the Diabetes Homeless Medication Support intervention vs. brief diabetes education will test the perception and feasibility of anticipated study procedures and refine randomization and blinding.
- Conditions
- Diabetes Mellitus, Type 2, Housing Problems, Psychological Distress
- Trial name
- D-HOMES (NCT05258630)
- Testing
- Diabetes Homeless Medication Support (D-Homes), Enhanced usual care
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Hennepin Healthcare Research Institute
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Exercise, Renal Dialysis
Exercise Effect on Psychological Distress of Patients Undergoing Hemodialysis at Al-Suwaiq Dialysis Center
The aim to investigate the level of psychological distress on patients undergoing hemodialysis at Al-Suwaiq Renal dialysis center as well as to explore the effectiveness of home-based exercise method in reducing such…
- Conditions
- Exercise, Renal Dialysis, Anxiety, Depression
- Trial name
- NCT07083843
- Testing
- Exercise, Standard medical treatment
- Where
- Oman
- Volunteers
- 54 people
- Sponsor
- Oman Ministry of Health