Clinical trials: Psychiatric Disorders
Nicotine Dependence
Nicotine's Potential Abuse With Menthol
To examine if switching from menthol to non-menthol cigarettes will change the dose-effect curves for positive subjective effects and alleviation of smoking urges as a function of nicotine delivery rate in smokers.
- Trial name
- NCT04535362
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Traumatic Brain Injury, Post-Traumatic Stress Disorder
Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Interventional, controlled clinical trial with two arms, 110 Veterans with TBI and PTSD
- Trial name
- COMPASS (NCT01816061)
- Testing
- Experimental - COMPASS, Control - COMPASS
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
HIV, Buprenorphine, and the Criminal Justice System
The aims of STRIDE were changed as of July, 2014. The revised project, called STRIDE2, has a longitudinal, non-randomized, observational study design.
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- STRIDE (NCT01550341)
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Housing Problems, Drug Use
ED-Home Pilot Study
This is a single-arm pilot study to test the feasibility of homelessness prevention and substance use interventions to be delivered to at-risk patients in the Bellevue Hospital emergency department (ED).
- Conditions
- Housing Problems, Drug Use, Alcohol; Use, Problem
- Trial name
- NCT03864341
- Testing
- Referral to homelessness prevention services, Substance use services, Follow-up
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Conduct Disorder
Trial of Aripiprazole in the Treatment of CD in Adolescents
The proposed study will be a 6-week open label study evaluating aripiprazole in the treatment of 12 male post-pubertal adolescents (13-17 years, Tanner Stage 4) diagnosed with conduct disorder.
- Trial name
- NCT00250705
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Major Depressive Disorder, Nicotine Dependence
Treatment of Nicotine Dependence and Acute Depression
The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression.
- Trial name
- NCT00186446
- Testing
- bupropion and smoking cessation behavioral intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Schizophrenia, Psychosis
Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia
Cognitive impairments in schizophrenia are the most debilitating aspect of the illness and poorly treated by current medications.
- Trial name
- NCT02975973
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Chronic Pain, Post Traumatic Stress Disorder (PTSD)
Transcranial Direct Current Stimulation Treatment for Warriors Experiencing Chronic Pain
The Veteran population has been known to deal with co-morbid chronic pain and PTSD. As a result, they use healthcare services at a higher rate than those Veterans with pain or PTSD alone which leads to an amplified burden on…
- Conditions
- Chronic Pain, Post Traumatic Stress Disorder (PTSD), Depression
- Trial name
- Warriors (NCT05254379)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Attention-Deficit/Hyperactivity Disorder
Pharmacokinetic Study of Methylphenidate HCl Extended-Release Capsules in Children 4 to Under 6 Years of Age With ADHD
To assess the pharmacokinetics of a single dose of Aptensio XR® (methylphenidate hydrochloride extended-release) capsules under fed conditions in male or female children 4 to under 6 years of age with ADHD.
- Trial name
- PK003 (NCT02470234)
- Testing
- Methylphenidate HCl ER Capsules, 10 mg, Methylphenidate HCl ER Capsules, 15 mg, Methylphenidate HCl ER Capsules, 20 mg
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Rhodes Pharmaceuticals, L.P.
Anorexia Nervosa
Feasibility Study Comparing Standard FBT and Guided Self-Help FBT for Adolescent Anorexia Nervosa
This study examines a parent only Guided Self-Help for Family Based Treatment (GSH-FBT) for adolescents between the ages of 12 and 18 diagnosed with Anorexia Nervosa.
- Trial name
- NCT04957498
- Testing
- Guided Self-Help for Family Based Treatment, Family Based Treatment
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Stanford University
Drug Toxicity
MW151-101: First-in-human Study of MW151
MW01-2-151SRM (=MW151), a small molecule, is being developed for the treatment of cognitive disorders. The development program is based on nonclinical evidence that MW151 improves neurocognitive outcomes in animal models of…
- Trial name
- NCT04120233
- Testing
- MW151, 10mg, MW151, 20mg, MW151, 40mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Linda Van Eldik
Alzheimer's Disease
A Study of Semorinemab in Patients With Moderate Alzheimer's Disease
This Phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate the clinical efficacy, safety, pharmacokinetics, and pharmacodynamics of semorinemab in patients with moderate AD.
- Trial name
- NCT03828747
- Testing
- Semorinemab, [18F]GTP1
- Where
- 49 sites in United States, France and 2 more
- Volunteers
- 272 people
- Sponsor
- Genentech, Inc.
Post Traumatic Stress Disorder
Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD
The purpose of this study is to quantify the therapeutic efficacy and role of trained service dogs on socio-emotional functioning among military veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT03245814
- Testing
- Service Dog
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Dementia, Alzheimer Type, Weight Loss
Partners at Meals - Respite Care and Home (PAM)
The goal of this study was to test the efficacy of a mealtime intervention in respite care centers for people with dementia and their caregivers.
- Trial name
- PAM (NCT03622814)
- Testing
- Partners at Meals, Enhanced Usual Condition
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Postpartum Depression, Parenting
Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms
The purpose of this study is to determine whether a social media-based parenting program can improve responsive parenting among mothers with Postpartum depression (PPD) symptoms.
- Conditions
- Postpartum Depression, Parenting, Parent-Child Relations
- Trial name
- NCT04045132
- Testing
- Social Media-Based Parenting Program, MoodGym
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Children's Hospital of Philadelphia
Posttraumatic Stress Disorder, Depression
A Trial of Group Psychotherapy for Veterans and Military Personnel With Post Traumatic Stress Disorder (PTSD)
The purpose of this study is to test the effectiveness of group psychotherapy designed specifically for male veterans and active-duty personnel with Post-traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD) and with…
- Conditions
- Posttraumatic Stress Disorder, Depression, Insomnia Disorder
- Trial name
- NCT00984698
- Testing
- Cognitive Behavioral Social Rhythm Group Therapy, Present Centered Group Therapy
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- University of Arizona
Insomnia
A Pilot Study of Suvorexant for Insomnia in Parkinson Disease
The purpose of this study is to see if the study drug, suvorexant, is safe and effective in treating symptoms of insomnia in people with Parkinson's Disease.
- Trial name
- NCT02729714
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Burdick, Daniel, M.D.
Major Depressive Disorder
A Phase 3 Study of Lu AA21004 in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the efficacy of two fixed doses of vortioxetine (Lu AA21004; 10 or 20 mg/day) after 8 weeks of treatment in patients with major depressive disorder (MDD) in Japan.
- Trial name
- NCT02389816
- Testing
- Vortioxetine
- Where
- 47 sites in Japan
- Volunteers
- 493 people
- Sponsor
- Takeda
Parkinson's Disease, Mild Cognitive Impairment
Cognitive Rehab for Parkinson's
This study will examine the feasibility of an at-home cognitive training program that incorporates both memory training and online computerized cognitive training (CCT) software.
- Trial name
- NCT03836963
- Testing
- cognitive training, active control cognitive training, memory strategy training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Psychotic Disorders, Psychosis
Pilot Study of Motivational Interviewing for Loved Ones
The study population for this research will include parents and concerned significant others (PCSO) of individuals experiencing recent (past five years) onset of a psychotic disorder (hereafter referred to as individuals with…
- Conditions
- Psychotic Disorders, Psychosis, Psychotic Episode
- Trial name
- MILO-Pilot (NCT04010747)
- Testing
- Motivational Interviewing for Loved Ones (MILO), Mental Health Services Consultation and Waitlist
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Boston Medical Center
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