Clinical trials: Pruritus
End Stage Renal Disease, Pruritus
Evaluating the Effect of Senna in Uremic Pruritus
Uremic pruritus remains one of the most frustrating and potentially disabling symptoms in patients with end stage renal disease. It affect up to 90 percent of patients with end stage renal disease.
- Trial name
- NCT02008864
- Testing
- Senna
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Atopic Dermatitis
Mind and Skin - the Neurocutaneous Axis in Atopic Eczema
'Mind and Skin': A prospective cohort study evaluating the impact of inflammation, itch and sleep disturbance on the brain, mental health and cognition, in patients with severe atopy.
- Trial name
- NCT05790330
- Testing
- Methotrexate, Dupilumab
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- King's College London
Chronic Pruritus of Unknown Origin
Efficacy and Safety of ATTO-1310 in the Treatment of Participants With Chronic Pruritus of Unknown Origin
The goal of this clinical trial is to assess the efficacy and safety of ATTO-1310 in patients with chronic pruritus/itch of unknown origin.
- Trial name
- NCT07833306
- Testing
- ATTO-1310
- Volunteers
- 300 people
- Sponsor
- Attovia Therapeutics Inc
Itching
Effect of Slow Injection of Fentanyl on the Incidence of Spinal Anesthesia Induced Itching in Cesarean Section
Pruritus is a troublesome side-effect of neuraxial (epidural and intrathecal) opioids. Sometimes it may be more unpleasant than pain itself.
- Trial name
- NCT02951806
- Testing
- (R) Rapid spinal fentanyl injection, (S) Slow spinal fentanyl injection
- Volunteers
- 215 people
- Sponsor
- Dr. Soliman Fakeeh Hospital
Chronic Spontaneous Urticaria, Recurrent Angioedema
Dupilumab in Chronic Spontaneous Urticaria
The purpose of this study is to assess the efficacy in reducing disease activity and safety of Dupilumab in adult patients with chronic spontaneous urticaria (CSU) who are symptomatic despite H1-antihistamine treatment.
- Trial name
- DUPICSU (NCT03749135)
- Testing
- Dupilumab
- Where
- 6 sites in Germany
- Volunteers
- 72 people
- Sponsor
- Charite University, Berlin, Germany
Pruritus
A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetics of HSK21542 Injection in Liver Disease Subjects With Pruritus
This study is a multi-center, randomized, double-blind, placebo-controlled study. About 90 liver disease subjects with moderate or above pruritus are planned to be enrolled.
- Trial name
- NCT04999787
- Testing
- HSK21542
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Atopic Dermatitis, Pruritus
Efficacy and Tolerability Study of Device, RD047-26 for the Treatment of Mild to Moderate Atopic Dermatitis in Adults
The purpose of this study is to find out if investigational device, RD047-26, is safe and useful for the treatment of mild to moderate atopic dermatitis.
- Trial name
- NCT01232985
- Testing
- RD047-26
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Oculus Innovative Sciences, Inc.
Senile Pruritus
Effects of Acupuncture for Senile Pruritus
Senile pruritus (SP), characterized by idiopathic itching in individuals aged 60 years and older without primary skin lesions, significantly impacts sleep and quality of life. Effective alternative treatments are needed.
- Trial name
- NCT06506240
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Uremic Pruritis
Sertraline Effect in Uremic Pruritis
This study aims to assess the effect of sertraline on uremic pruritis in patients undergoing regular haemodialysis.
- Trial name
- NCT05341843
- Testing
- sertraline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Atopic Dermatitis, Pruritus
Treatment of Chronic Itch in Atopic Dermatitis With Topical Naltrexone
To study the etiology and the epigenetic pathways leading to and regulating chronic itch. Similarly, to examine the mechanisms underlying skin changes, including epigenetic alterations while also testing the efficacy of…
- Conditions
- Atopic Dermatitis, Pruritus, Dermatitis
- Trial name
- NCT04154033
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- University of Minnesota
Dry Nose, Nose Irritation
Pilot Study to Assess Performance and Safety of SULFEX 13081.22 Nasal Spray in Patients With Dry or Irritated Nose
As the medical device is CE marked, the objective of this study is to provide performance and safety data on SULFEX 13081.22 nasal spray as close as possible to the routine care.
- Trial name
- NCT05499078
- Testing
- SULFEX 13081.22
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Church & Dwight Company, Inc.
Prurigo Nodularis, Pruritis
Study to Assess the Efficacy, Safety, and Tolerability of Vixarelimab in Reducing Pruritus in Prurigo Nodularis
Study of the efficacy, safety, tolerability, pharmacokinetics (PK), and immunogenicity of Vixarelimab (KPL-716) in subjects with prurigo nodularis (PN).
- Trial name
- NCT03816891
- Testing
- Vixarelimab
- Where
- 86 sites in United States, Australia and 11 more
- Volunteers
- 240 people
- Sponsor
- Genentech, Inc.
Atopic Dermatitis
The Effect of Intervention and Mechanism of ICBT on Chronic Itching in Patients With Atopic Dermatitis
Objectives: The study subjects were 180 healthy people from the dermatology clinic of Xiangya Hospital of Central South University and the surroundingcommunity, including 120 AD patients (60 in the ICBT treatment group and 60 in…
- Trial name
- NCT05502848
- Testing
- Internet Cognitive Behavior Therapy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Psoriasis, Cutaneous T Cell Lymphoma
Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases
The molecular mechanisms of action of photo(chemo)therapy in skin diseases are investigated in this study. The phototherapeutic modalities employed include UVB (ultraviolet B), UVA (ultraviolet A), PUVA (psoralen+UVA) and/or…
- Conditions
- Psoriasis, Cutaneous T Cell Lymphoma, Lymphoproliferative Disorders, Eczema
- Trial name
- BioUV2017 (NCT03340155)
- Testing
- Photo(chemo)therapy
- Where
- Austria
- Volunteers
- 240 people
- Sponsor
- Medical University of Graz
Bullous Pemphigoid
A Study to Investigate the Use of Benralizumab in Patients With Bullous Pemphigoid.
The purpose of this study is to investigate the use of benralizumab is effective in the treatment of patients symptomatic Bullous Pemphigoid (BP).
- Trial name
- FJORD (NCT04612790)
- Testing
- Benralizumab
- Where
- 39 sites in United States, Australia and 9 more
- Volunteers
- 67 people
- Sponsor
- AstraZeneca
Bladder Cancer
The Impact of Intrathecal Morphine Versus Continuous Epidural Analgesia on Return of Bowel Function in Patients Undergoing Laparoscopic Ileal Conduit
This study aims to compare the effects of intrathecal morphine (ITM) and continuous epidural analgesia (CEA) on bowel function recovery after Bricker surgery.This study was a prospective, randomized controlled trial that included…
- Trial name
- NCT06688643
- Testing
- ITM group, EA group
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xiaguang Duan
Pregnancy Related, Atopic Dermatitis
An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis Exposed to Ruxolitinib Cream Versus Topical Corticosteroids During Pregnancy: A US Claims Database Analysis
This study is to assess infant outcomes of women with AD who were exposed to ruxolitinib cream during pregnancy compared with a control cohort of women with AD who were exposed to a topical corticosteroid (TCS) during pregnancy.
- Trial name
- NCT06627335
- Testing
- Ruxolitinib Cream, TCS
- Where
- United States
- Volunteers
- 5,621 people
- Sponsor
- Incyte Corporation
Primary Biliary Cirrhosis
Nalfurafine Hydrochloride for Pruritus in Patients With Primary Biliary Cholangitis
Nalfurafine hydrochloride is a selective kappa-opioid receptor agonist developed in Japan, and in May 2015 the use of nalfurafine hydrochloride was officially approved in Japan for pruritus in patients with chronic liver diseases…
- Trial name
- NCT02659696
- Where
- Japan
- Volunteers
- 44 people
- Sponsor
- Teikyo University
Pruritus
Comparison of Epidural Oxycodone and Epidural Morphine
The primary objectives of this study are to compare the efficacy of pain relief between epidural oxycodone and epidural morphine for postoperative analgesia after elective caesarean section and to compare the incidence and…
- Trial name
- NCT02277678
- Testing
- Opioid administration oxycodone, Opioid administration morphine
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- KK Women's and Children's Hospital
Dry Skin, Urticaria
A Clinical Study to Assess the Safety and Effectiveness of Utixira Lotion and Utixira Tablet in Healthy Adult Human Subjects With Dry or Sensitive Skin Prone to Mild to Moderate Pruritus and Urticaria
This exploratory, prospective, open-label, single-centre, safety, efficacy and in-use tolerability study of the Utixira Lotion + Utixira Lotion as regimen in healthy adult human subjects with dry or sensitive skin and prone to…
- Conditions
- Dry Skin, Urticaria, Pruritus, Sensitive
- Trial name
- NCT06924840
- Testing
- Utixira Lotion tablet as regimen
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- SAVA Healthcare Limited