Clinical trials: Prosthetic Infection
Prosthetic Joint Infection
Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection
The PROOF Study is an open prospective interventional non-randomized study which aim is to determine the outcome / effect and safety of fosfomycin in patients with hip, knee or shoulder PJI.
- Trial name
- NCT05211011
- Testing
- Fosfomycin
- Where
- 16 sites in Germany
- Volunteers
- 226 people
- Sponsor
- Charite University, Berlin, Germany
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- NCT04787250
- Testing
- Phage Therapy, Two-Stage Exchange Arthroplasty
- Where
- United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Prosthetic-joint Infection
Surgiphor vs Saline Joints
This study will be an open-label superiority, multicenter, single-blind, controlled randomized clinical trial investing the role of a PVP-I irrigation solution (Surgiphor) in reducing the risk of acute PJI in the 90 days…
- Trial name
- NCT05434260
- Testing
- Surgiphor Irrigation Solution, Sterile saline
- Where
- 4 sites in United States
- Volunteers
- 868 people
- Sponsor
- Center for Innovation and Research Organization
Infections Joint Prosthetic
Egyptian Arthroplasty Surgeons' Antibiotics Usage Awareness
Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are procedures successfully applied to manage various end-stage chronic hip and knee diseases, such as osteoarthritis, rheumatoid arthritis, and femoral head…
- Trial name
- NCT06451224
- Testing
- Questionnaire
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- South Valley University
Prostheses Infection
Efficacy and Tolerance of 4 Weeks of Tedizolid in Prosthetic Joint Infections Treated With Implant Removal
To evaluate the efficacy of 4 weeks of 200 mg/24h of tedizolid for prosthetic join infections caused by tedizolid susceptible microorganisms treated with implant removal in one or two stages at 6 months of followup after stopping…
- Trial name
- PROTEDI (NCT03746327)
- Testing
- Sivextro 200 milligrams Oral Tablet
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Osteoarticular Infections
Molecular Microbiology in Osteo-arthritis Infection
Osteoarticular infections are painful and disabling diseases that require antimicrobial treatment adapted to the microorganisms implicated.
- Trial name
- MOLOS (NCT01193803)
- Testing
- Microbiological cultures and Molecular biology
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hernia, Ventral
Complex Ventral Hernia Repair Using Biologic or Synthetic Mesh
Hernias are often treated using a prosthetic mesh to add support to the healing wound. Prosthetic meshes have been used for decades to repair ventral hernias, level 1 data regarding which type of mesh to use is limited.
- Trial name
- CVHR (NCT02041494)
- Testing
- Ventralight, Strattice
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Hobart Harris
Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection
Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.
This prospective observational diagnostic study aims to improve the accuracy and timeliness of diagnosing chronic periprosthetic joint infection (PJI).
- Conditions
- Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection, Prosthetic Joint Failure of Unclear Etiology
- Trial name
- PJI MAP/DEF (NCT07494630)
- Testing
- Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- University Hospital, Ghent
Prosthetic Joint Infection
68Ga-citrate PET/CT for the Diagnosis of Chronic Prosthetic Hip or Knee Infection
Diagnosis of chronic prosthetic joint infection (PJI) can be difficult. 68Ga-citrate Positron Emission Tomography/Computed Tomography (PET/CT) has been recently developed and has many advantages such as high resolution and low…
- Trial name
- Gal-I-TEP (NCT04938193)
- Testing
- 68Ga-citrate PET/CT
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Bordeaux
Prosthetic Joint Infection
Measuring Distress in Prosthetic Joint Infection Using a Standardized Metric: CRUTCH Pathway Pilot.
The purpose of this study is to determine whether patients being treated for prosthetic joint infections (PJI) experience distress during the course of their treatment and how distress influences various aspects of their lives.
- Trial name
- NCT04762706
- Testing
- CRUTCH Pathway
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- West Virginia University