Clinical trials: Prostheses
Intervertebral Disc Displacement
Comparison of Software-assisted Implantation of Elastic Spine Pad (TM) With Respect to Postoperative Change in Neck Disability Index (NDI) With the Conventional Disc Prosthesis Rotaio (TM) After Anterior Cervical Discectomy for Cervical Disc Prolapse
This is an investigator-initiated study. The primary goal is to evaluate the efficacy of two different cervical disc prosthetic devices with respect to postoperative change in neck disability index.
- Trial name
- NCT02936739
- Testing
- Anterior cervical discectomy with prosthetic disc replacement / ESP., Anterior cervical discectomy with prosthetic disc replacement / Rotaio.
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Technische Universität Dresden
Alzheimer's Dementia (AD)
AMPER Proof of Concept Study
The AMPER (Agent-based Memory Prosthesis to Encourage Reminiscing) system has been built to help people with Alzheimer's disease by improving their memory recall and quality of life.
- Trial name
- AMPER (NCT06894953)
- Testing
- Personalised Agent-based Memory Prosthesis to Encourage Reminiscing (AMPER), Non-Personalised Agent-based Memory Prosthesis to Encourage Reminiscing (AMPER)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Strathclyde
Prosthesis Failure, Dental
Clinical Success of Anterior and Posterior Crowns in a Group of Children Treated Under General Anesthesia
This incidence study aims to evaluate the clinical success of anterior and posterior full-coverage restorations among a group of Egyptian children treated under general anesthesia.
- Trial name
- NCT06201481
- Testing
- anterior and posterior full coverage crowns
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Total Ankle Prosthesis
HINTEGRA Total Ankle Prosthesis Follow-up
The Hintegra® Total Ankle Prosthesis is a non constrained, three-component prosthesis that consists of a flat tibial component, an anatomically-shaped talar component, and a high-density polyethylene inlay.
- Trial name
- NCT01284972
- Where
- 6 sites in Austria, Canada and 4 more
- Volunteers
- 225 people
- Sponsor
- Integra LifeSciences Services
Osteoarthritis, Post-traumatic Arthritis
Postoperative Function Following Partial and Total Knee Replacement
The purpose of this study is to determine if patients with a fixed-bearing or mobile-bearing partial knee replacement perform functional activities differently than patients that have had total knee replacement or healthy…
- Trial name
- NCT00492219
- Testing
- Vanguard M fixed-bearing or Oxford mobile-bearing prostheses, Total Knee Replacement
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- New Lexington Clinic
Aortic Valve Disease
Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)
The ASCEND post-market clinical follow-up study is undertaken to evaluate safety and clinical performance of the On-X Ascending Aortic Prosthesis (AAP) used in surgical aortic valve replacement.
- Trial name
- ASCEND (NCT05082454)
- Testing
- Open repair
- Where
- 11 sites in United States, Germany and 3 more
- Volunteers
- 108 people
- Sponsor
- JOTEC GmbH
Indications for a Total Hip Prosthesis
Primary Ceramic-on-Ceramic Total Hip Replacement Versus Metal-on-Metal Hip Resurfacing in Young Active Patients
Comparison of the functional result and speed of rehabilitation between two types of hip prostheses: primary ceramic-on-ceramic total hip replacement versus metal-on-metal hip resurfacing.
- Trial name
- NCT00285129
- Testing
- ceramic-on-ceramic total hip replacement versus metal-on-metal hip resurfacing
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- University Hospital, Ghent
Knee Arthritis, Knee Osteoarthritis
In-vivo Wear Behaviour of AS Coated Versus Uncoated Columbus® Total Knee Prosthesis
This clinical study is a Post-Market Clinical Follow-Up (PMCF) measure and is aiming to compare the in-vivo wear behaviour of the Columbus® total knee prosthesis between the standard Cobalt Chromium (CoCr) and the multilayer…
- Conditions
- Knee Arthritis, Knee Osteoarthritis, Primary Osteoarthritis of Knee Nos, Secondary Osteoarthritis of Knee Nos
- Trial name
- COLRAS (NCT05509972)
- Testing
- total knee prosthesis implantation
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Aesculap AG
Amputation, Diabetes Complications
Use of Subtle Vibration to Improve Walking Ability by Lower Limb Amputees
The purpose of this study is to determine if subthreshold vibration, when applied to the residual limb of a lower limb amputee through their prosthetic socket, can sufficiently enhance peripheral sensation to result in an…
- Trial name
- NCT00985881
- Testing
- Custom prosthetic socket with mechanical vibrators (stochastic resonance), Conventional prosthetic socket (current clinical practice)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Valvular Endocarditis
Surgical Management of Valvular Endocarditis
This study aims to achieve the following objectives objective 1 : To review the Investigators' experience of surgical management of infective endocarditis (IE) and analyze the outcomes and associated prognostic factors objective…
- Trial name
- NCT04572529
- Testing
- Cardiac Valve replacement
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chest Wall Tumors, Post-traumatic Syndrome
"Multicenter Registry for Chest Wall Reconstruction Using Custom Dynamic Prostheses (PRODIPET)"
PRODIPET Study Summary Title: Multicenter Registry for Chest Wall Reconstruction Using Custom 3D-Printed Titanium Prostheses Purpose The PRODIPET study evaluates the safety and effectiveness of personalized, dynamic titanium…
- Conditions
- Chest Wall Tumors, Post-traumatic Syndrome, Malignant Bone Tumor of Chest Wall
- Trial name
- PRODIPET (NCT07018960)
- Testing
- Chest wall reconstruction with 3D printed titan custom prothesis
- Where
- 5 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Infection
Antibiotic Prophylaxis in Total Knee Prosthesis
Knee prosthesis infection is a severe complication. The use of a tourniquet during surgery impairs the efficacy of the antibiotic prophylaxis.
- Trial name
- NCT00497341
- Testing
- cefuroxime
- Where
- Spain
- Volunteers
- 1,332 people
- Sponsor
- Hospital Clinic of Barcelona
Localized Prostate Adenocarcinoma
Feasibility of MR-Informed Adaptive Marker-less SBRT in Patients With Bilateral Hip Prostheses Undergoing SBRT for Localized Prostate Cancer
Hip replacements and prostate cancer are independently and both together increasing prevalent in the aging population. In the United States, the prevalence of hip prostheses among men was 1.1 million in 20101, with approximately…
- Trial name
- HIP-PRO (NCT07042256)
- Testing
- Low-field MR-informed adaptive marker-less SBRT for definitive treatment of localized prostate cancer in patients with bilateral hip prostheses
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- University of Zurich
Transtibial Amputee, Transtibial Amputation
Feasibility Study Evaluating the Safety and Effectiveness of Magnetic Bead Tracking System When Used With a Bionic External Prosthesis
The investigation is an early feasibility study in up to 5 subjects, in which the primary objective is to capture preliminary safety and effectiveness information on the Magnetic Bead Tracking system.
- Trial name
- NCT07195461
- Testing
- Magnetic Bead Tracking System
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- MuscleMetrix, LLC
Amputation of Lower Limb
Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss
The goal of clinical trial is to assess an integrated, patient-centered strategy combining user preference-based prosthetic foot prescription and subsequent targeted physical therapy to maximize satisfaction and mobility outcomes…
- Trial name
- OPORP (NCT06844305)
- Testing
- Prosthetic foot, Physical therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Knee Prosthesis
Study of the Prognostic Value of the Coagulolytic Balance Dependent on Circulating Microvesicles in the Occurrence of Thrombotic Events After Total Knee Replacement in Orthopedic Surgery.
This is a prospective multicenter cohort study to evaluate the prognostic value of new biological markers in predicting thrombotic events after orthopedic surgery.
- Trial name
- MOTiVE (NCT05387694)
- Testing
- Thrombotic risk assessment
- Where
- France
- Volunteers
- 387 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Implant Site Reaction, Implant Complication
Retention, Chewing Efficiency and Masticatory Performance of Partial Dentures Opposing Implant Retained Prosthesis.
This study aims to evaluate retention ,chewing efficiency and masticatory performance of flexible versus CAD/CAM partial dentures opposing to fixed implant retained restorations.
- Trial name
- NCT05999760
- Testing
- evaluation of retention of Versacryle and CAD/CAM partial dentures by force gauge, chewing efficiency by electromyograph(E.M.G), masticatory performance(questionnaire)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- National Research Centre, Egypt
Spinal Cord Injuries
Active Powered Prosthesis (APEX) for Spinal Cord Injury
The Active Powered Prosthesis (APEX) (AbiliTech Medical Inc., Minneapolis, MN) is a proof-of-concept shoulder-elbow-wrist device intended to provide non-invasive active powered robotic assistive movement to upper extremities.
- Trial name
- NCT03696927
- Testing
- Active Powered Prosthesis (APEX) for Spinal Cord Injury
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- AbiliTech Medical Inc.
Erectile Dysfunction, Impotence
PROPPER Prospective Registry of Outcomes With Penile Prosthesis
The purpose of this observational registry is to collect and better understand "real-world" outcomes for men undergoing penile implant surgery to treat erectile dysfunction.
- Trial name
- PROPPER (NCT01383018)
- Testing
- AMS Penile Prosthesis Devices
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,457 people
- Sponsor
- Boston Scientific Corporation
Erectile Dysfunction (ED)
IPP Placement & Intracavernosal Block
The inflatable penile prosthesis (IPP) is the gold standard for surgical management of erectile dysfunction (ED) and there is no consensus on the best postoperative pain management regimen.
- Trial name
- IPP (NCT07246642)
- Testing
- Exparel/bupivacaine mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences