Clinical trials: Prostatic Hyperplasia
Benign Prostatic Hyperplasia
Transperineal Irreversible Electroporation for Benign Prostatic Hyperplasia
This clinical trial focuses on men with benign prostatic hyperplasia (BPH), a condition in which an enlarged prostate causes urinary problems.
- Trial name
- NCT06867315
- Testing
- Composite steep-pulse therapeutic device (CNP-III)
- Where
- 10 sites in China
- Volunteers
- 99 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Benign Prostatic Hyperplasia
Ultrasound-Guided vs. Conventional Prostate Suspension in BPH: An Exploratory Study
This is an exploratory, prospective, single-center, open-label, 1:1 randomized controlled study. The study compares two surgical methods for benign prostatic hyperplasia (BPH): ultrasound-guided prostate suspension and…
- Trial name
- NCT07873125
- Testing
- Ultrasound-Guided Prostatic Urethral Lift, Conventional Prostatic Urethral Lift
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai East Hospital
Benign Prostatic Hyperplasia (BPH)
REZŪM vs. Dual Drug Therapy for Symptomatic Benign Prostatic Hyperplasia in Sexually Active Men
The study objective is to compare water vapor thermotherapy with the REZŪM™ System to dual drug therapy for the treatment of symptomatic benign prostatic hyperplasia refractory to alpha-blocker monotherapy in sexually active men.
- Trial name
- VAPEUR (NCT04838769)
- Testing
- REZŪM, alpha blocker and 5-alpha reductase inhibitor
- Where
- 21 sites in Australia, France
- Volunteers
- 155 people
- Sponsor
- Boston Scientific Corporation
Overactive Bladder, Urinary Urgency Incontinence
Sacral Neuromodulation for Male Overactive Bladder (MOAB)
To assess the post-market clinical outcomes of the Axonics SNM System for treatment of overactive bladder in male patients.
- Conditions
- Overactive Bladder, Urinary Urgency Incontinence, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT06511141
- Testing
- Axonics SNM System
- Where
- 23 sites in United States
- Volunteers
- 150 people
- Sponsor
- Axonics, Inc.
Benign Prostate Hypertrophy(BPH), Renal Calculi
Stone and Laser Therapies Post-Market Study (SALT)
The objective of the SALT Study is to obtain post-market safety and device performance data for Boston Scientific's Stone and BPH study devices used during a diagnostic and/or therapeutic urinary tract procedure (e.g.…
- Conditions
- Benign Prostate Hypertrophy(BPH), Renal Calculi, Ureteral Stones, Kidney Stones, Calculi, Urinary
- Trial name
- SALT (NCT06982235)
- Testing
- Ureteroscope system, Laser system
- Where
- 5 sites in United States
- Volunteers
- 238 people
- Sponsor
- Boston Scientific Corporation
Benign Prostatic Hyperplasia (BPH)
Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is a common condition affecting aging men, often leading to lower urinary tract symptoms (LUTS).
- Trial name
- ECHOLASER (NCT07016620)
- Testing
- Transperineal Laser Ablation (TPLA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Benign Prostatic Hyperplasia
Efficacy and Safety of Combination Therapy Compared With Monotherapy in Patients With Benign Prostatic Hyperplasia
Efficacy and Safety of Combination Therapy Compared With Monotherapy in Patients With Benign Prostatic Hyperplasia
- Trial name
- NCT07870759
- Testing
- Finasteride 5 mg Tablet, single dose, Tamsulosin 0.4Mg Capsule
- Volunteers
- 660 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Benign Prostatic Hyperplasia, Stress Urinary Incontinence (SUI)
Optimization of Surgical Treatment Pathways for BPH Based on Real-World Data
Benign prostatic hyperplasia is a noncancerous enlargement of the prostate that can cause difficulty urinating. Holmium laser enucleation of the prostate (HoLEP) uses a laser to remove prostate tissue blocking urine flow.
- Trial name
- NCT07872085
- Testing
- Conventional HoLEP Without Apical Pre-disconnection, HoLEP With Fixed 12 O'clock Apical Pre-disconnection, HoLEP With MRI-Guided Individualized Apical Pre-disconnection
- Where
- China
- Volunteers
- 153 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Benign Prostatic Hyperplasia, Transurethral Resection of the Prostate
Tranexamic Acid for Bleeding Reduction During TURP Surgery
Transurethral resection of the prostate (TURP) is commonly performed in elderly patients and may be associated with perioperative bleeding leading to postoperative anemia and delayed recovery.
- Conditions
- Benign Prostatic Hyperplasia, Transurethral Resection of the Prostate, Perioperative Bleeding, Anemia, Postoperative
- Trial name
- TXA-TURP (NCT07460518)
- Testing
- Tranexamic Acid
- Where
- Morocco
- Volunteers
- 80 people
- Sponsor
- Hamza Najout
BPH (Benign Prostatic Hyperplasia)
HoLEP-ThuLEP - Comparing Lasers for BPH Surgery
Benign prostatic hyperplasia (BPH) is a very common condition in older men. As the prostate enlarges, it can press on the urethra and make urination difficult.
- Trial name
- HOT (NCT07565961)
- Testing
- Thulium Laser Enucleation of the Prostate (ThuLEP), Holmium Laser Enucleation of the Prostate (HoLEP)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Calculi, Renal, Calculi, Urinary
Modified SOLTIVE Study
This is a study to collect procedural data during the use of the SOLTIVE™ Premium SuperPulsed Laser System in the treatment of bladder, ureteral, and kidney stones and BPH to inform the development of software algorithms.
- Conditions
- Calculi, Renal, Calculi, Urinary, Benign Prostatic Hyperplasia
- Trial name
- NCT07838077
- Testing
- SOLTIVE Premium SuperPulsed Laser System
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Olympus Corporation of the Americas
Transurethral Resection of Prostate Syndrome, Prostate Hyperplasia
Transurethral Prostate Resection (TURP) vs. Prostate Artery Embolization (PAE)
This study focuses on the treatment of benign prostatic hyperplasia which causes lower urinary tract symptoms. The purpose of the research project is to evaluate PAE in terms of both medical and health economic outcomes.
- Conditions
- Transurethral Resection of Prostate Syndrome, Prostate Hyperplasia, Embolization, Therapeutic
- Trial name
- NCT05531240
- Testing
- Prostate Artery Embolization, Transurethral Prostate Resection (TURP)
- Where
- 4 sites in Sweden
- Volunteers
- 104 people
- Sponsor
- Uppsala University
Benign Prostatic Hyperplasia
Evaluation of the Functional Outcomes After Bilateral, 3D Ultrasound-guided Focal Thermal Ablation of the Prostate Transition Zone, in Patients With Benign Prostatic Hyperplasia-related Obstruction
The aim of the current study is to evaluate the efficacy of transperineal focal microwave ablation (TMA) of the prostate transition zone as a new treatment for lower urinary tract symptoms (LUTS) due to benign prostatic…
- Trial name
- BETTANY (NCT06212453)
- Testing
- Targeted Microwave Ablation
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Benign Prostatic Hyperplasia With Outflow Obstruction, Urinary Retention
Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate
The purpose of this study is to allow us to assess the effectiveness (or success) of starting pelvic floor physical therapy (i.e.
- Conditions
- Benign Prostatic Hyperplasia With Outflow Obstruction, Urinary Retention, Lower Urinary Tract Symptoms
- Trial name
- NCT06179654
- Testing
- Preoperative pelvic floor physical therapy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The Cleveland Clinic
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Ultrasound IPP to Predict Response to Medical Therapy in LUTS/BPH
This prospective cohort study evaluated whether transabdominal ultrasound measurement of intravesical prostatic protrusion predicts symptom severity and response to medical therapy in men aged 50 years or older with lower urinary…
- Conditions
- Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms, Bladder Outlet Obstruction
- Trial name
- NCT07306767
- Testing
- Transabdominal ultrasound measurement of intravesical prostatic protrusion, Alpha-adrenergic blocker, 5-alpha reductase inhibitor
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University
Prostate Cancer, Lower Urinary Tract Symptoms (LUTS)
Concomitant Trans-Perineal Prostate Biopsy and Ablation (Bioblation) for Prostate Cancer
This prospective study aims to validate the clinical outcomes of performing a concomitant trans-perineal prostate biopsy and laser ablation (termed "Bioblation") during a single session.
- Conditions
- Prostate Cancer, Lower Urinary Tract Symptoms (LUTS), Benign Prostatic Hyperplasia
- Trial name
- Bioblation (NCT07526675)
- Testing
- Bioblation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Benign Prostatic Hyperplasia (BPH)
Post-Market Study to Assess iTind Safety in Comparison to UroLift
The study objective is to evaluate the efficacy and safety of the iTind device compared to UroLift.
- Trial name
- MT-08 (NCT04757116)
- Testing
- iTind, UroLift
- Where
- 19 sites in United States, United Kingdom
- Volunteers
- 256 people
- Sponsor
- Olympus Corporation of the Americas
Benign Prostatic Hyperplasia
Urolift Pre-SBRT for Reduced Urinary Toxicity in Patients With BPH and Prostate Cancer.
Many patients may face long-term urinary side effects following stereotactic body radiation therapy (SBRT), including increased urinary frequency, dysuria, and nocturia.
- Trial name
- NCT05148156
- Testing
- Urolift
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Benign Prostatic Hyperplasia
Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial)
After surgery for benign prostatic hyperplasia (BPH) that physically removes the prostatic transition zone (such as TURP or laser enucleation), many men are routinely sent home with a 2- to 4-week prescription of an alpha-blocker…
- Trial name
- CLEAR (NCT07846579)
- Testing
- Tamsulosin hydrochloride 0.2 mg
- Volunteers
- 400 people
- Sponsor
- Shanghai East Hospital
Urology, Urinary Bladder, Overactive
Ambulatory Long Length URodynamics Evaluation
A prospective, open-label, single arm interventional trial evaluating the safety and performance of the in-clinic and extended monitoring of the lower urinary tract using the Glean Urodynamics System.
- Conditions
- Urology, Urinary Bladder, Overactive, Benign Prostatic Hyperplasia, Urodynamics
- Trial name
- ALLURE (NCT07425015)
- Testing
- Glean Urodynamics System
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Bright Uro