Clinical trials: Prostatic Diseases
Prostate Cancer
Active Surveillance Magnetic Resonance Imaging Study
This is a multi-centre, prospective, randomized phase III trial to determine if multi-parametric Magnetic Resonance Imaging (MRI) can improve selection of patients eligible for active surveillance through better detection of…
- Trial name
- ASIST (NCT01354171)
- Testing
- MRI assisted TRUS guided biopsy
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Canadian Urology Research Consortium
Androgenetic Alopecia
Effects of Finasteride on Serum Prostate-Specific Antigen (0906-111)
A clinical study to collect additional data in order to characterize the reduction in PSA with finasteride 1 mg, and its reversibility in men with androgenetic alopecia between the ages of 40 to 60 years.
- Trial name
- NCT00396175
- Testing
- MK0906, finasteride / Duration of Treatment : 48 Weeks
- Volunteers
- 355 people
- Sponsor
- Organon and Co
Prostatic Cancer
To Evaluate the Technique and Effects of Separating the Prostate and Rectum With Hyaluronic Acid During Radiotherapy
The dominating problem after local radiotherapy of prostate cancer is rectal toxicity. If the rectum could be completely moved out of the treated volume, a substantial decrease of rectal toxicity seems reasonable.
- Trial name
- NoHarm (NCT01787630)
- Testing
- Hyaluronic acid
- Where
- 3 sites in Sweden
- Volunteers
- 81 people
- Sponsor
- Anders Widmark
Prostate Cancer, CDK12 Gene Mutation
RC48 Monotherapy or Combination With Envafolimab for CDK12 Alterations mCRPC With Standard Treatment Failure
The aim of this study is to evaluate the efficacy and safety of vediximab monotherapy or in combination with enrolizumab for second-line treatment of CDK12 alterations mCRPC that has failed standard therapy.
- Trial name
- NCT06663007
- Testing
- RC48, Envafolimab
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Tianjin Medical University Second Hospital
Prostate Cancer
A Dose Finding Study With I.V. Panobinostat (LBH589), Docetaxel, and Prednisone in Patients With Hormone Refractory Prostate Cancer
This Phase Ib dose escalation study is designed to characterize the safety, tolerability and preliminary efficacy of i.v. panobinostat (LBH589) in combination with docetaxel and prednisone in the 1st line treatment of patients…
- Trial name
- NCT00663832
- Testing
- LBH589 (i.v. panobinostat)
- Where
- 9 sites in United States, Canada
- Volunteers
- 44 people
- Sponsor
- Novartis Pharmaceuticals
Prostate Cancer, Lower Urinary Tract Symptoms (LUTS)
Concomitant Trans-Perineal Prostate Biopsy and Ablation (Bioblation) for Prostate Cancer
This prospective study aims to validate the clinical outcomes of performing a concomitant trans-perineal prostate biopsy and laser ablation (termed "Bioblation") during a single session.
- Conditions
- Prostate Cancer, Lower Urinary Tract Symptoms (LUTS), Benign Prostatic Hyperplasia
- Trial name
- Bioblation (NCT07526675)
- Testing
- Bioblation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Benign Prostate Hypertrophy(BPH)
Transurethral Focal Laser Ablation Versus Transurethral Prostatectomy For Management Of Benign Prostatic Obstruction
Introduction and objectives: Laser prostatectomy has become an increasingly popular and effective alternative to transurethral resection of the prostate (TURP) for the treatment of benign prostatic hyperplasia (BPH).-.
- Trial name
- NCT07196475
- Testing
- FOCAL LASER ABLATION OF PROSTATE
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Benign Prostatic Hypertrophy
Saline With Alcohol in TransUrethral Resection aNd Photoselective Vaporisation of the Prostate
Transurethral therapy (TURiS / PVP) of benign prostatic hyperplasia (BPH) using an ethanol-containing saline irrigating fluid, prospective detected by breath alcohol measurement.
- Trial name
- SATURN-P (NCT02429219)
- Testing
- Saline Irrigation with Ethanol, transurethral resection of the prostate, photoselective vaporisation of the prostate
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Magdeburg
Breast Neoplasms, Prostatic Neoplasms
Investigating the Impact of Tailored Reports on Anxiety Amongst Cancer Patients and Their Confidants
Objective: To explore the hypothesis that different methods of selecting and printing information for cancer patients could improve emotional support by affecting interaction with others, and so lead to improved psychological…
- Conditions
- Breast Neoplasms, Prostatic Neoplasms, Laryngeal Neoplasms, Cervix Neoplasms
- Trial name
- NCT00127465
- Testing
- Issue of information booklet
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Plymouth
Lower Urinary Tract Symptoms, Hypertension
Effect of Amlodipine Monotherapy or Combined With Terazosin on Lower Urinary Tract Symptoms and Hypertension
The aim of this study was to investigate the efficacy and safety of low dose amlodipine alone, or combined with low dose terazosin in male patients with both lower urinary tract symptoms and hypertension.
- Trial name
- NCT00693199
- Testing
- amlodipine, terazosin, amlodipine plus terazosin
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Anhui Medical University
Prostate Cancer
Intraprostatic PRX302 Injection to Treat Localised Prostate Cancer
The purpose of this study is to determine a safe, effective, and tolerable dose of PRX302 for the treatment of low to intermediate risk prostate cancer.
- Trial name
- NCT03081481
- Testing
- PRX302
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 38 people
- Sponsor
- Sophiris Bio Corp
Prostate Cancer
Radical Radiotherapy by External Beam Radiation Versus Radical Radiotherapy With Temporary Iridium Implant Plus External Beam Radiation in Carcinoma of the Prostate
The specific objective of this study is to compare the relative efficacy of the combination of a temporary iridium implant plus external beam irradiation versus standard external beam irradiation alone in patients with Stage B2…
- Trial name
- NCT00548600
- Testing
- Iridium Implant, Standard external beam irradiation
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Prostate Cancer
Initiation of Androgen Deprivation Therapy for Prostate Cancer Using Degarelix Followed by Leuprolide
The purpose of this study is to determine if patients initiating androgen deprivation therapy (ADT) for prostate cancer can be transitioned from degarelix acetate to leuprolide acetate after an initial three-month period without…
- Trial name
- NCT01344564
- Testing
- Degarelix acetate, Leuprolide acetate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Urology of Virginia
Bladder Cancer
Comparison Capsule Sparing Cystectomy and Radical Cystoprostatectomy in Men With Bladder Cancer
Bladder cancer is a common malignant tumor of the urinary system, radical resection plus urinary diversion is the first choice of treatment for muscle invasive bladder cancer.
- Trial name
- NCT05067101
- Testing
- Capsule Sparing Cystectomy (CSC), Conventional Radical Cystoprostatectomy (CRC)
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Zhujiang Hospital
Prostatic Adenoma
Teverelix Evaluated in Advanced Prostate Cancer
The purpose of this study is to assess the safety and efficacy of teverelix TFA in the treatment of advanced prostate cancer
- Trial name
- TEACh (NCT04693507)
- Testing
- teverelix TFA 120 mg, teverelix TFA 180 mg
- Where
- 4 sites in Lithuania
- Volunteers
- 50 people
- Sponsor
- Antev Ltd.
Prostate Cancer
Optimizing Prostate Biopsy Schemes in Men With Multiple MRI Visible Lesions
The goal of this randomized controlled trial (RCT) is to evaluate the efficacy of different prostate biopsy schemes in prostate cancer diagnosis among men with multiple MRI visible lesions, including combination of targeted and…
- Trial name
- NCT06841211
- Testing
- Targeted and perilesional biopsy (TPLBx), Combined targeted and systematic biopsy (CTSBx)
- Where
- China
- Volunteers
- 572 people
- Sponsor
- Peking University First Hospital
Prostatic Neoplasm of Uncertain Behavior
Combining High-frequency Micro-ultrasound and Multiparametric MRI Target Biopsy for Detecting Prostate Cancer
Study Goal: The purpose of this clinical trial is to determine if combining high-frequency micro-ultrasound with multiparametric MRI biopsy and a systematic biopsy can better detect clinically significant prostate cancer compared…
- Trial name
- Biopsy29 (NCT06579911)
- Testing
- High-frequency micro-ultrasound target biopsy, conventional Multiparametric MRT target biopsy
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Benign Prostatic Hyperplasia (BPH)
French Aquablation Clinical Investigation Using Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue
Single arm, multi-center prospective clinical trial to determine the safety and effectiveness of the AQUABEAM System in the treatment of benign prostatic hyperplasia (BPH) in men 45 to 80 years of age.
- Trial name
- NCT03191734
- Testing
- AQUABEAM System
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- PROCEPT BioRobotics
Prostate Cancer
Selenomethionine in Treating Patients Undergoing Surgery or Internal Radiation Therapy for Stage I or Stage II Prostate Cancer
RATIONALE: Selenomethionine may slow the growth of prostate cancer. Giving selenomethionine before surgery or internal radiation therapy may be an effective treatment for prostate cancer.
- Trial name
- NCT00736164
- Testing
- selenomethionine
- Sponsor
- Roswell Park Cancer Institute
Prostate Cancer
Weekly Docetaxel and Bortezomib in the Treatment of Advanced Hormone-Refractory Prostate Cancer
Evaluation of the effectiveness of weekly docetaxel/bortezomib as first-line chemotherapy for patients with advanced hormone-refractory prostate cancer.
- Trial name
- NCT00193232
- Testing
- Docetaxel, Bortezomib
- Volunteers
- 50 people
- Sponsor
- SCRI Development Innovations, LLC