Clinical trials: Propofol Injection Pain
Pain
Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation
This is a double blind, randomized, controlled study. The sedationist performing the sedation procedure will inject the appropriate amount of either a 1% Lidocaine solution or a placebo before the administration of Propofol.
- Trial name
- NCT02512783
- Testing
- Lidocaine, Normal Saline, Propofol
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Injections, Intravenous
Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain
Intravenous lidocaine is commonly given through an intravenous (IV) line prior to injection of propofol to reduce the amount of pain during propofol injection.
- Trial name
- NCT03057704
- Testing
- Lidocaine injection flushed, Lidocaine injection tourniquet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Anesthesia
Use of a Modified Propofol Emulsion in Adults
The purpose of the study is to determine whether a modified propofol preparation shows any effect on the incidence of injection pain in adults undergoing elective surgery under general anesthesia.
- Trial name
- NCT00690495
- Testing
- Propofol, Propofol 1%
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- B. Braun Melsungen AG
Neuroblastoma
Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients
The purpose of this study is to identify whether or not the addition of a numbing medicine that is injected directly into the site of the bone marrow procedure can reduce pain and the use of opioid pain medication after bone…
- Trial name
- NCT02924324
- Testing
- propofol, ropivacaine, Wong-Baker FACES® Pain Rating Scale
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pain on IV Injection of Propofol.
Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection
The main objective is to evaluate if combining placing the Synera patch and using Propofol /Lidocaine mixture will further decrease the pain associated with the IV injection of Propofol.
- Trial name
- NCT02240628
- Testing
- Lidocaine/tetracaine transdermal patch, Saline, Lidocaine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Complication of Injection, Pain
Preventing Propofol Injection Pain: Prospective Randomized Trial Comparing Propofol Versus Fospropofol
The purpose of this study is to compare the incidence and intensity of possible pain on injection as well as patient satisfaction caused by propofol (a lipid based medication); Lusedra (a water based medication); and the drug…
- Trial name
- NCT01401049
- Testing
- Fospropofol, Propofol/Lidocaine
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- NYU Langone Health
General Anesthesia, Intravenous Anesthesia
Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol
Since the introduction of propofol into routine anesthesia practice, the phenomena of pain on injection has plagued anesthesia providers. Propofol, an unstable phenol, triggers the release of bradykinin on injection.
- Trial name
- NCT01342510
- Testing
- Magnesium Sulfate, Lidocaine, Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Injection Site Irritation
Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial
This study is a randomized, single-site clinical trial that will take place at Children's Healthcare of Atlanta at Egleston. The investigators want to see if in pediatric patients, giving Zofran prior to propofol, reduces the…
- Trial name
- NCT05378113
- Testing
- Ondansetron, Lidocaine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Emory University
Pain
Preventing Propofol-associated Injection Pain
Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients.
- Trial name
- NCT00864682
- Testing
- Saline, Lidocaine / propofol admixture, lidocaine pretreatment
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Benaroya Research Institute
Injection Site Irritation, Pain
Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain
The primary hypothesis is that esmolol and lidocaine, when given without the use of a tourniquet, provide relief of propofol injection pain that is superior to placebo when assessed using the propofol pain scoring tool
- Trial name
- NCT04356352
- Testing
- Lidocaine, Esmolol
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences