Clinical trials: Propofol
Injection Site
Efficacy of TEAS On Prevention of Propofol Injection Pain in Children
The purpose of this study is to determine the efficacy of transcutaneous electrical acupoint stimulation for the prevention of propofol injection pain in children.
- Trial name
- NCT05296187
- Testing
- TEAS
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Sedation in ERCP
Propofol Versus Dexmedetomidine for Sedation of Cancer Patients Undergoing ERCP
The aim of this study is to compare the efficacy and safety of propofol and dexmedetomidine during ERCP regarding hemodynamic, respiratory, sedative and cognitive functions.
- Trial name
- NCT06409104
- Testing
- Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 202 people
- Sponsor
- National Cancer Institute, Egypt
Propofol Injection Pain in Children
Determining if the Buzzy® Personal Pain Relief Device Reduces Injection Pain of Propofol as Much as Intravenous Lidocaine in Children
Propofol is a drug commonly used for induction of general anesthesia in children as well as adults; however, propofol can cause pain on injection, possibly more frequently in children.
- Trial name
- NCT07770581
- Testing
- Buzzy device, Intravenous lidocaine
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
General Anaesthesia
Evaluation of Equivalent Minimum Alveolar Concentration (eMAC) During Propofol/Remifentanil Anesthesia
The aim of this study is to verify the accuracy of eMAC compared to Bispectral Index (BIS) for depth and nociceptive stimulation monitoring of anesthesia during general anesthesia.
- Trial name
- eMAC (NCT05789992)
- Testing
- Propofol, Low Remifentanil, Heigh Remifentanil
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Zhang Haopeng
Major Depression, Bipolar Affective Disorder
Treatment Response In ECT Patients
Clarification Regarding Study Type: Observational This study is a prospective, non-interventional observational study. The decision to administer Electroconvulsive Therapy (ECT) and the selection of the anesthetic agent (ketamine…
- Conditions
- Major Depression, Bipolar Affective Disorder, Bipolar Depression Depressed Phase
- Trial name
- NCT07463911
- Testing
- Electroconvulsive Therapy (ECT)
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Nurdan Sağbaş
Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia
The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Induction
It is a prospective, randomized, placebo-controlled study to investigate the effect of TEA with different block level on propofol concentration during general anesthesia induction.
- Conditions
- Target Controlled Infusion (TCI), Thoracic Epidural Anesthesia, Block Level, Gastrointestinal Surgery
- Trial name
- NCT02135016
- Testing
- 1% lidocaine, 2% lidocaine, 0.9% normal saline
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Hospital of China Medical University
Delayed Graft Function, Renal Outcome After Kidney Transplantation
Volatile Anesthetic Protection Of Renal Transplants 2
To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on the incidence of DGF in recipients of kidneys of donation after circulatory death (DCD) and donation after brain death (DBD) donors
- Conditions
- Delayed Graft Function, Renal Outcome After Kidney Transplantation, Acute Rejection (AR) of Transplanted Kidney, Graft Survival
- Trial name
- VAPOR-2 (NCT02727296)
- Testing
- sevoflurane, propofol
- Where
- 5 sites in Denmark, Netherlands and 2 more
- Volunteers
- 488 people
- Sponsor
- University Medical Center Groningen
Hemodynamic Instability
Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position
Most of the major spinal surgeries are performed in the supine position, which causes a decrease in stroke volume and cardiac index, which leads to the occurrence of hypotension during surgery.
- Trial name
- NCT05644483
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Asan Medical Center
Hypothyroidism, Anesthesia, General
Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient
Introduction: GABAergic synaptic transmigration in the anterior cingulate (ACC) cortex of hypothyroid rats has been demonstrated by electrophysiologic recordings.
- Conditions
- Hypothyroidism, Anesthesia, General, Propofol Dosage, Magnetic Resonance Imaging (MRI)
- Trial name
- BrainGABA (NCT06649318)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Laryngospasm
Laryngeal Reflex Study Under Propofol Anesthesia: Effect of Intravenous Lidocaine
To describe respiratory and laryngeal responses to laryngeal stimulation during propofol anesthesia in children. To determine whether the co-administration of lidocaine blunts these reflex responses.
- Trial name
- LR6 (NCT01222169)
- Testing
- NaCl 0,9%
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Thomas Erb
Obesity
Balanced Propofol Sedation During Upper Endoscopy in Morbidly Obese Patients
The purpose of this study is to evaluate the safety of propofol-based, gastroenterologist-administered sedation in severely obese patients (BMI≥35) undergoing upper endoscopy.
- Trial name
- NCT00782873
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Research Associates of New York, LLP
Invasive Cancer, Pediatric Cancer
Comparing TIVA Using Propofol or Dexmedetomidine Versus Sevoflurane During Anaesthesia of Children Undergoing Bone-Marrow Aspiration
No doubt that children facing surgical procedures are subjected to perioperative distressing, anxious and worrying periods. Several factors included; parental deprivation, anxiety, previously mismanaged experience and…
- Trial name
- NCT05636566
- Testing
- Sevoflurane, Propofol infusion for maintance, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Induction of General Anesthesia
Propofol Versus Sevoflurane for Induction of GA in Infants
This comparative study aims to investigate the haemodynamic safety profile for induction of general anesthesia in infants 3 months or less guided by electrical cardiometry parameters versus sevoflurane.
- Trial name
- NCT05105022
- Testing
- Propofol
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Procedural Sedation
Effects of Sedation Agents on Optic Nerve Sheath Diameter
This prospective observational study aims to evaluate the acute effects of ketamine and propofol sedation on optic nerve sheath diameter (ONSD) in adult patients undergoing procedural sedation in the emergency department.
- Trial name
- NCT07882524
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Alanya Alaaddin Keykubat University
Aged, Neoplasms
Impact of Anesthesia Maintenance Methods on 5-year Survival After Surgery
Surgery is one of the major treatment methods for patients with solid organ cancer. And, alone with the ageing process, more and more elderly patients undergo surgery for cancer.
- Conditions
- Aged, Neoplasms, Surgical Procedure, Operative, Anesthesia, Inhalation
- Trial name
- NCT05343260
- Testing
- Sevoflurane, Propofol
- Where
- 15 sites in China
- Volunteers
- 1,228 people
- Sponsor
- Peking University First Hospital
Shoulder Pain
Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
The standard hospital procedure calls for the patient to undergo Interscalene block under ultrasound with or without nerve stimulation guidance prior to going to operating room (OR).
- Trial name
- TIVA (NCT02469961)
- Testing
- Dexmedetomidine, Propofol, Interscalene block
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maimonides Medical Center
Hypercarbia
The Effect of Ketamine in the Prevention of Hypoventilation in Patients Undergoing Deep Sedation Using Propofol and Fentanyl
Procedures performed under sedation have the same severity in regards to morbidity and mortality as procedures performed under general anesthesia1.
- Trial name
- NCT01825083
- Testing
- Ketamine
- Where
- United States
- Sponsor
- Northwestern University
Orthopedic Disorder
Pupilometric Evaluation of Patients Under Procedural Sedation With Propofol
Procedural sedation involves the administration of sedative medications that allow patients to tolerate painful procedures. Procedural sedation has been formally recommended by experts from the French Society of Emergency…
- Trial name
- ALGISAP 2023 (NCT05750485)
- Testing
- Pupilometric evaluation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
General Anaesthesia, Propofol
Blood Propofol Measurement During Anaesthesia Using Propofol Target Controlled Infusion
Propofol is a commonly used agent for sedation and anaesthesia in the intensive care unit and the operating room. The pharmacokinetics of propofol are difficult to predict in patients not conforming to the norms in which the…
- Conditions
- General Anaesthesia, Propofol, Target Controlled Infusion, Pharmacokinetics
- Trial name
- NCT01549639
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Flexible Bronchoscopy
Target-Controlled Infusion of Propofol for Flexible Bronchoscopy Sedation
Flexible bronchoscopy (FB) sedation requires keeping sedative level in a narrow window to prevent over or under sedation. Sedative drug titration according to subjective adjustment by individual physician may cause unsteady drug…
- Trial name
- NCT01101477
- Testing
- TCI titration by different Cet.
- Where
- Taiwan
- Volunteers
- 144 people
- Sponsor
- Chang Gung Memorial Hospital