Clinical trials: Prophylaxis of Bleeding
Portal Hypertension Related to Cirrhosis
Carvedilol vs Band Ligation vs Combination Therapy for Primary Prophylaxis of Variceal Bleeding
Subjects will be those individuals greater than 18 years of age with a diagnosis of cirrhosis undergoing screening for esophageal varices.
- Trial name
- NCT02066649
- Testing
- Carvedilol, Variceal band ligation
- Where
- United States
- Sponsor
- Rutgers, The State University of New Jersey
Postpartum Hemorrhage
Oxytocin Via Intramuscular Injection and Intravenous Bolus or Infusion for Prevention of Postpartum Hemorrhage
The study will evaluate whether prophylactic oxytocin administered in the third stage of labor via intravenous (IV) infusion or IV bolus reduces the rate of postpartum hemorrhage compared to intramuscular (IM) injection.
- Trial name
- NCT01914419
- Testing
- Oxytocin
- Where
- 2 sites in Egypt
- Volunteers
- 4,983 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Ulcer Bleeding, Upper Gastrointestinal Tract Bleeding
The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers
Non-variceal acute gastrointestinal bleeding is a common and potentially life-threatening problem. The conventional treatment of this condition is for esophagogastroduodenoscopy (OGD) for haemostasis.
- Trial name
- NCT03160911
- Testing
- Over-the-scope clip (OTSC), Conventional Endoscopic Haemostasis
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Placenta Previa
Vaginal Progesterone Versus 17-Alpha-Hydroxyprogesterone Caproate in Placenta Previa
Purpose to evaluate the effects of Vaginal Progesterone versus 17-Alpha-Hydroxyprogesterone Caproate for prevention of Emergent Cesarean Delivery in Asymptomatic Pregnant Women with Placenta Previa
- Trial name
- NCT03779451
- Testing
- 17-OHPC, vaginal progesterone
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Aswan University Hospital
Cirrhosis
Carvedilol + VSL#3 Versus Endoscopic Variceal Ligation for Primary Prophylaxis of Esophageal Variceal Bleeding in Cirrhotic Patients Non Responder to Carvedilol.
Patients of cirrhosis will be enrolled who have large esophageal varices, which have never bled. After successful screening baseline hepatic venous pressure gradient (HVPG) will be measured.
- Trial name
- NCT01196481
- Testing
- Carvedilol+VSL#3, Endoscopic variceal ligation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Peptic Ulcer Hemorrhage
Ilaprazole for the Treatment and Prevention of Peptic Ulcer Bleeding in Chinese Patients
The purpose of this phase study is to confirm the efficacy and safety by compare ilaprazole and omeprazole in the treatment and prevention of peptic ulcer bleeding.
- Trial name
- NCT03362281
- Testing
- Ilaprazole, Omeprazole, Ilaprazole tablet
- Volunteers
- 540 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Cirrhosis, Liver Hypertension, Portal Variceal Hemorrhage
Prophylactic Antibiotics in the Endoscopic Secondary Prevention of Cirrhotic Patients With Varices: a Retrospective Study
Whether prophylactic antibiotics should be administered in the endoscopic secondary prevention of GVB or not is unclear. In this retrospective study, we are aimed to evaluate whether prophylactic antibiotics confer advantages in…
- Trial name
- NCT07616466
- Testing
- No use of prophylactic antibiotics, Prophylactic Antibiotics
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation, Intracranial Hemorrhages
A Pilot Study on the Prevention of the Vascular RISK Related to Atrial Fibrillation After Intracranial Hemorrhage by Closing the Left Auricle
Atrial fibrillation (AF) is a frequent heart rhythm disorder, responsible for the formation of cardiac thrombi, which can embolize in the systemic circulation, responsible for strokes (Cerebrovascular accidents).
- Trial name
- RIVAFAG (NCT03111654)
- Testing
- Compare the risk of a vascular event
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hip Fracture, Blood Loss
Prevention of Postoperative Bleeding in Subcapital Femoral Fractures
The main hypothesis of this clinical trial is that the use of intra-articular tranexamic acid and the fibrin glue plus usual hemostasis will reduce at least a 25% the postoperative blood loss with respect to usual hemostasis in…
- Trial name
- TRANEXFER (NCT02150720)
- Testing
- Tranexamic Acid, Fibrin glue, Electrocauterization
- Where
- 6 sites in Spain
- Volunteers
- 161 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
We prepare this study to compare the efficacy of intermittent intravenous PPI infusion (relatively low dose PPI therapy) than continous PPI infusion method.
- Conditions
- Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage, Peptic Ulcer, Proton Pump Inhibitor Overdose
- Trial name
- NCT03814421
- Testing
- intermittent (40mg as a bolus injection daily for 72hours)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Changwon Hospital
Pain, Ecchymosis
Effect of Hypericum Perforatum Oil on Ecchymosis and Pain
Low molecular weight heparin is a drug with anticoagulant and antithrombotic effects. This drug is frequently administered subcutaneously to patients by nurses.
- Trial name
- NCT06367036
- Testing
- Topical hypericum perforatum oil intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Uskudar University
Aneurysm, Vasospasm
Balloon Prophylaxis of Aneurysmal Vasospasm
The purpose of this study is to determine if early transluminal ballooning of the major cerebral arteries prevents severe vasospasm and improves neurological outcome in patients with Fisher Grade III aneurysmal subarachnoid…
- Trial name
- NCT00282893
- Testing
- transluminal ballooning, currently existing therapies for the treatment of vasospasm
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 170 people
- Sponsor
- University of California, Davis
Bleeding Gastric Varices
To Compare the Efficacy of Endoscopic Ultrasound Assisted Endoscopic Glue Injection and Conventional Endoscopic Injection Therapy for Prevention of Gastric Variceal Rebleed
Consecutive patients who meet the eligibility criteria will be enrolled into the study. All patients with gastric varices with no history of gastric variceal bleed (Group C) will undergo Endoscopic ultrasound and Upper…
- Trial name
- NCT01631890
- Testing
- Endoscopic Ultrasound assisted endoscopic glue injection, Standard Endotherapy
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hemophilia A
Safety and Efficacy of BAY94-9027 in Previously Treated Male Children With Haemophilia A
Hemophilia A is an inherited blood disorder in which one protein, Factor VIII, needed to form blood clots is missing or not present in sufficient levels.
- Trial name
- NCT01775618
- Testing
- BAY94-9027
- Where
- 37 sites in United States, Argentina and 15 more
- Volunteers
- 73 people
- Sponsor
- Bayer
Hypothermia
Plastic Hat Trial to Prevent Hypothermia in Preterm Newborns in the Delivery Room
The purpose of this research project is to ascertain the effectiveness of plastic head covering in prevention of hypothermia. Hypothermia is defined by body temperature <36.5º Celsius by the World Health Organization.
- Trial name
- NCT00904228
- Testing
- placement of plastic cap during delivery room stabilization, placement of routine cap during delivery room stabilization
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postpartum Haemorrhage
Treatment of Postpartum Haemorrhage (PPH) Using Misoprostol in Home Births
A double-blind individual randomized controlled study of misoprostol vs. placebo for treatment in homebirths in the Chitral district, in the Khyber Pakhtunkhwa province in Pakistan.
- Trial name
- NCT01485562
- Testing
- Misoprostol
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Hemorrhage
Reversal Dabigatran Anticoagulant Effect With Idarucizumab
The trial objective is to demonstrate the safety of idarucizumab, as assessed by the occurence of patients with drug related adverse events (including immune reactions) and all-cause mortality in paediatric venous thromboembolism…
- Trial name
- NCT02815670
- Testing
- Idarucizumab
- Where
- 2 sites in Russia
- Volunteers
- 1 people
- Sponsor
- Boehringer Ingelheim
Stress Ulcer Prophylaxis
Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients
The efficacy of esomeprazole will be compared versus cimetidine (a drug that previously demonstrated prevention of bleeding events) during treatment period in proportion of patients for the prevention of upper GI bleeding.
- Trial name
- SUP (NCT02157376)
- Testing
- Esomeprazole, Cimetidine
- Where
- 15 sites in China
- Volunteers
- 343 people
- Sponsor
- AstraZeneca
Brain Ischemia, Intracranial Hemorrhages
PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage
Through this study, the investigators are to prove that Cilostazol effectively prevent cardiovascular events in ischemic stroke patients with high risk of cerebral hemorrhage, along with no significant increase in the risk of…
- Trial name
- PICASSO (NCT01013532)
- Testing
- Cilostazol, Probucol, Aspirin
- Where
- 71 sites in China, Philippines and 1 more
- Volunteers
- 1,600 people
- Sponsor
- Asan Medical Center