Clinical trials: Prophylaxis
Leukemia, Lymphoma
Bortezomib-based GVHD Prophylaxis After Allogeneic Transplant for Patients Without Matched Related Donors
A common problem after stem cell transplant is graft-versus-host-disease (GVHD). GVHD is a complication of transplantation where the donor graft attacks and damages some of your tissues.
- Conditions
- Leukemia, Lymphoma, Myelodysplastic Syndrome
- Trial name
- NCT01323920
- Testing
- Bortezomib, Tacrolimus, Methotrexate
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Dana-Farber Cancer Institute
Hip Fracture, Blood Loss
Prevention of Postoperative Bleeding in Subcapital Femoral Fractures
The main hypothesis of this clinical trial is that the use of intra-articular tranexamic acid and the fibrin glue plus usual hemostasis will reduce at least a 25% the postoperative blood loss with respect to usual hemostasis in…
- Trial name
- TRANEXFER (NCT02150720)
- Testing
- Tranexamic Acid, Fibrin glue, Electrocauterization
- Where
- 6 sites in Spain
- Volunteers
- 161 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Infectious Diseases
Rapamycin and Infection-related Illness
Conduct a 6-month observational pilot clinical trial to evaluate the safety, monitor the adverse reactions and observe the preliminary effectiveness of medical treatment with oral rapamycin [Rapamune (Sirolimus)] in a total of 15…
- Trial name
- NCT07054320
- Testing
- Observational procedures
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hoskinson Health and Wellness Clinic
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
Suicide, Attempted
Inpatient Post Admission Cognitive Therapy (PACT) for the Prevention of Suicide Attempts
The broad objective of this research is to effectively utilize a unique window of opportunity during the hospitalization period following a recent suicide attempt to deliver a brief and targeted intervention for suicidal…
- Trial name
- NCT01340859
- Testing
- Post Admission Cognitive Therapy (PACT)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Preeclampsia
Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort
This study intends to adopt the method of multi-center prospective randomized controlled study. The aim of this study is to obtain localized excision values through a preeclampsia screening model established in early pregnancy…
- Trial name
- NCT04631627
- Testing
- Aspirin
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Radiation Induced Oral Mucositis
Benzydamine vs Supersaturated Calcium Phosphate Oral Rinses for Radiation Induced Oral Mucositis in Head and Neck Cancer Patients.
The goal of this clinical trial is to compare and correlate salivary macrophage migratory inhibitory factor levels with onset and severity of radiation induced mucositis in head and neck cancer patients by using super saturated…
- Trial name
- NCT07748442
- Testing
- Benzydamine hydrochloride mouthrinse, Super saturated calcium phosphate oral rinses
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Antibiotics Causing Adverse Effects in Therapeutic Use
Clindamycin Versus Amoxicillin With Clavulanic Acid in Prevention of Early Dental Implants Failure
Among patients receiving dental implants, does the choice of antibiotics reduce the frequency of early implant failure ?
- Trial name
- NCT04980170
- Testing
- Clindamycin 300 mg, Amoxicillin with Clavulanic Acid 635mg
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- Jordan University Hospital
Nausea, Vomiting
Olanzapine Against Delayed Nausea and Vomiting in Women Receiving Carboplatin Plus Paclitaxel
This randomized, pilot study explores the activity of olanzapine with or without delayed dexamethasone for the prevention of delayed nausea and vomiting in women with gynecologic cancer receiving the combination of carboplatin…
- Trial name
- NCT02290470
- Testing
- Olanzapine, Palonosetron, Dexamethasone, Carboplatin, Paclitaxel, Olanzapine
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Postoperative Pain
The Prevention of Postoperative Epidural Catheter Migration: a Comparison of Three Types of Dressing
Three types of dressing will be compared to prevent postoperative epidural catheter migration. Patients will be randomised to have a Tegaderm dressing, an Epi-fix dressing or a Lockit-Plus dressing to secure the epidural catheter…
- Trial name
- NCT00764283
- Testing
- Tegaderm dressing, Epi-Fix dressing, Lockit-Plus
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Ghent
Hemorrhage Lung, Endobronchial Mass
Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy
Transbronchial cryobiopsies are common procedures used to obtain tissue samples from airways for diagnostic purposes. While these procedures are safe, there is a risk of bleeding from the biopsy site.
- Trial name
- CRYOTXA (NCT06266546)
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Youssef Yammine
Bladder Cancer, Cystostomy; Complications
Evaluation of Naloxegol in the Prevention of POI After Cystectomy
Postoperative ileus (POI) is defined as a transient reduction of bowel motility that prevents effective transit of bowel content and tolerance of oral intake following surgical interventions, especially after radical cystectomy.
- Trial name
- ANTAGOCYST (NCT04219046)
- Testing
- Naloxégol oxalate
- Sponsor
- Institut Paoli-Calmettes
Depression, Depressive Disorder
Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles @Schule" (i Am Everything @school)
The aim of this study is to investigate the naturalistic user experience and acceptance of the German website "ich bin alles @Schule".
- Conditions
- Depression, Depressive Disorder, Depression in Children, Depression in Adolescence
- Trial name
- NCT06668688
- Testing
- "ich bin alles @Schule" (i am everything @school; www.schule.ich-bin-alles.de)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Inguinal Hernia, Hydroceles
Prevention of Surgical Site Infection in Open Paediatric Groin Surgeries Using Intravenous Prophylactic Antibiotics and Antimicrobial-coated Sutures
The goal of this clinical trial is to learn if the use of prophylactic antibiotics and antimicrobial-coated sutures can prevent surgical site infection in children undergoing open groin surgeries.
- Conditions
- Inguinal Hernia, Hydroceles, Surgical Site Infection
- Trial name
- NCT07346742
- Testing
- Antimicrobial-coated sutures, Intravenous Cefuroxime
- Where
- Nigeria
- Volunteers
- 174 people
- Sponsor
- Olawumi Olajide
Liver Cirrhosis, Hepatitis B
Prevention of HCC Using Mobile Phone Applications
This prospective cohort study is initiated to evaluate the compliance improvement to the standardized follow-up and clinical management in the population of compensatory hepatitis B cirrhosis with a mobile health application…
- Trial name
- NCT05094869
- Testing
- Use of mobile health application, Online interaction, Self follow-up reminders
- Volunteers
- 8,000 people
- Sponsor
- Beijing Friendship Hospital
Diabetic Nephropathy, Diabetic Retinopathy
Proteomic Prediction and Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic nephRopathy In TYpe 2 Diabetic Patients With Normoalbuminuria
This is a prospective, multicenter, randomized, double blind, placebo-controlled and a prospective observational study. This study will be conducted at 15 study centers in various European countries.
- Trial name
- PRIORITY (NCT02040441)
- Testing
- Spironolactone, Standard care
- Where
- 15 sites in Belgium, Czechia and 8 more
- Volunteers
- 1,777 people
- Sponsor
- Peter Rossing
Burnout Syndrome
Effectiveness of an Intervention for Prevention and Treatment of Burnout in Primary Care
Background: Burnout syndrome is an important health problem that affects many professionals and must be addressed globally, with both organizational measures and personal interventions.
- Trial name
- EDESPROAP (NCT01870154)
- Testing
- Training
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Gerencia de Atención Primaria, Madrid
HIV Prevention
Post-Injectable Cabotegravir Antiretroviral Salvage Strategy Options Trial
This is a single-arm, open-label, effectiveness study designed to evaluate the use of Tenofovir, Lamivudine, and Dolutegravir in people with newly diagnosed HIV-1 infection initiating first-line Antiretroviral Therapy with…
- Trial name
- PICASSO (NCT06485154)
- Testing
- TLD - Tenofovir Disoproxil Fumarate / Lamivudine / Dolutegravir
- Where
- 3 sites in South Africa
- Volunteers
- 100 people
- Sponsor
- University of Witwatersrand, South Africa
Breast Cancer
Iron Supplement in the Prevention of Anemia in Female Breast Cancer Patients
Study to evaluate the efficacy of intravenous iron supplementation in the prevention of anemia in patients receiving (neo)adjuvant breast cancer regimens.
- Trial name
- NCT01168505
- Testing
- ferric hydroxide saccharate
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Athletic Performance, Plyometric Exercise
A Randomized Crossover Study on Diverse Training Methods to Enhance University Athletes' Performance and Health
The goal of this randomized crossover study is to investigate the effects of plyometric training, functional training, and whole-body electrical muscle stimulation (WB-EMS) on athletic performance and health in university…
- Conditions
- Athletic Performance, Plyometric Exercise, Healthy
- Trial name
- NCT06546605
- Testing
- Whole-Body Electrical Muscle Stimulation (WB-EMS) Training, Plyometric Training, Functional Training
- Where
- 2 sites in Macau
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Macau