Clinical trials: Prophylaxis
Covid19
Hydroxychloroquine as Chemoprevention for COVID-19 for High Risk Healthcare Workers
The study proposes to conduct an open-label Phase II trial to evaluate the feasibility, safety and early efficacy of hydroxychloroquine (HCQ) administration in reduction of transmission of severe acute respiratory syndrome…
- Trial name
- NCT04345653
- Testing
- Hydroxychloroquine Sulfate (HCQ)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting (PONV) in Surgical Patients
This study will compare two different drug regimens (oral dronabinol versus intravenous ondanseteron) for the prevention of post-operative nausea and vomiting (PONV).
- Trial name
- PONV (NCT00757822)
- Testing
- Dronabinol, Ondansetron
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Smoking Cessation
Effectiveness of WhatsApp Online Group Discussion for Smoking Relapse Prevention
This study aims to examine the effectiveness and cost-effectiveness of WhatsApp group discussion for smoking relapse prevention.
- Trial name
- NCT03760224
- Testing
- WhatsApp group, SMS group
- Where
- Hong Kong
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Post-ERCP Acute Pancreatitis
Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
Post-ERCP pancreatitis is a well-known and sometimes life-threatening complication of ERCP. Both LR and rectal indomethacin have shown benefit in preventing post-ERCP pancreatitis.
- Trial name
- IND+LRPEP (NCT02641561)
- Testing
- Indomethacin, Lactated Ringer's Solution, Normal Saline
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Cooper Norcross Health
Risk Assessment, Parenting
Randomized Controlled Trial of a Risk Reframing Tool to Change Mothers' Parenting Associated With Children's Risky Play
Children's risky play is associated with a variety of positive developmental, physical and mental health outcomes, including greater physical activity, self-confidence and risk management skills.
- Trial name
- NCT03374683
- Testing
- RR Digital Tool, RR In-Person Workshop, Position Statement on Active Outdoor Play
- Where
- Canada
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Volunteers
Immunogenicity of Recombinant Vesicular Stomatitis Vaccine for Ebola-Zaire (rVSV∆G-ZEBOV-GP Vaccine)
Background: The Ebola virus causes a severe disease that can be fatal. The usual incubation period to illness after being exposed is 2 to 21 days. There are only limited treatments currently available for Ebola infection.
- Trial name
- NCT02788227
- Testing
- rVSV∆G-ZEBOV-GP Vaccine (V920)
- Where
- 3 sites in United States, Canada
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alcohol Consumption, Alcohol Use Disorder
Step Away: Comparing a Chatbot-delivered Alcohol Intervention With a Smartphone App
A wide gap exists between the number of people needing alcohol treatment and those actually receiving it. This study builds on a previous one that indicated that smartphone-based intervention can help increase the number of…
- Trial name
- NCT04447794
- Testing
- Step Away Chatbot, Step Away App
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University of Alaska Anchorage
Leprosy
Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar
This is a cluster randomized trial on effectiveness of different modalities of Single Double Dose of Rifampicin Post-Exposure Prophylaxis (SDDR-PEP) for leprosy in the Comoros (Anjouan and Mohéli) and Madagascar.
- Trial name
- PEOPLE (NCT03662022)
- Testing
- Rifampicin
- Where
- 3 sites in Comoros, Madagascar
- Volunteers
- 144,000 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
HIV/AIDS
Packaging PrEP to Prevent HIV Among WWID
Evidence suggests women who inject drugs (WWID) are disproportionately vulnerable to HIV. If HIV incidence continues unchecked, 1 in 23 WWID in the United States will acquire HIV.
- Trial name
- NCT03304912
- Testing
- PrEP Education and option to accept a PrEP prescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Drexel University
Pediatric Obesity, Risk Reduction Behavior
FirstStep2Health Intervention
This project will determine the preliminary efficacy of an innovative intergenerational intervention among Head Start preschoolers, aged 3-5 years, and their caregivers.
- Conditions
- Pediatric Obesity, Risk Reduction Behavior, Early Intervention, Intergenerational Relations
- Trial name
- NCT04164277
- Testing
- Caregiver Component., Caregiver-Preschooler Learning., Center-based Preschooler Component.
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Alzheimer Disease, Alzheimer Disease (AD)
Phase I Clinical Study of AV-1959R: Abeta-targeting Anti-Alzheimer's Vaccine
This Phase 1 clinical trial evaluates the safety, tolerability, and immune response of the adjuvanted AV-1959R vaccine in healthy adults aged 40-60.
- Conditions
- Alzheimer Disease, Alzheimer Disease (AD), Alzheimers Disease Prevention
- Trial name
- NCT06831812
- Testing
- AV-1959R (Abeta vaccine)
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Nuravax, Inc.
Pertussis
Vanderbilt Pertussis Exposure Study: PEP in Vaccinated Healthcare Workers Following Pertussis Exposure
The purpose of this study is to compare the effectiveness of two strategies of post-exposure prophylaxis (PEP) in healthcare workers (HCWs) who have been vaccinated with acellular pertussis vaccine and have been exposed to…
- Trial name
- VPES (NCT00469274)
- Testing
- Antibiotic PEP
- Where
- United States
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Breast Cancer
Soy Isoflavones and Breast Cancer Risk Reduction
Soy consumption has been associated with reduced risk for developing breast cancer. Soy contains isoflavones which are weak estrogens. The roles of soy isoflavones in reducing breast cancer risk are currently unclear.
- Trial name
- NCT00204490
- Testing
- isoflavones, carbohydrate
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Bullying
BullyDown, a Text Messaging-based Bullying Prevention Program for Middle School-aged Youth
Given the limited impact of existing school-based interventions and the time associated with implementing them during school time, more efficient and effective intervention methods are needed.
- Trial name
- NCT06017050
- Testing
- BullyDown, Attention-matched control
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Center for Innovative Public Health Research
COVID-19
The PATCH Trial (Prevention And Treatment of COVID-19 With Hydroxychloroquine)
The PATCH trial (Prevention And Treatment of COVID-19 with Hydroxychloroquine) is funded investigator-initiated trial that includes 3 cohorts.
- Trial name
- PATCH (NCT04329923)
- Testing
- Hydroxychloroquine Sulfate 400 mg twice a day, Hydroxychloroquine Sulfate 600 mg twice a day, Hydroxychloroquine Sulfate 600 mg once a day
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ravi Amaravadi, MD
Nicotine Dependent Cigarette Smoker
The Get Quit - Stay Quit Study
Narrative: Tobacco smoking remains the single biggest cause of premature death in the United States and the leading cause of cancer and death from cancer.
- Trial name
- GQSQ (NCT01980485)
- Testing
- Lung Age feedback and exhaled carbon monoxide, No Lung Age Feedback
- Where
- 4 sites in United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Prevention of Rotavirus Gastroenteritis in Infants and Children Caused by Serotypes G1, G2, G3, G4, and G9
Immunogenicity and Safety of Concomitant and Non-Concomitant Administration of RotaTeq® (V260) and Inactivated Poliomyelitis Vaccine in Healthy Chinese Infants (V260-074)
This study will evaluate the immunogenicity and safety of concomitant administration of RotaTeq® (V260) and inactivated poliomyelitis vaccine (IPV) in Chinese infants.
- Trial name
- NCT04481191
- Testing
- RotaTeq (V260), IPV
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Central Obesity
Soy as an Innovative Dietary Component in Abdominal Obesity Management Amongst Peri- and Early Menopausal Women
This is a pilot study examining the effect of dietary supplements that contain soy products. The purpose of this study to find out if soy supplementation can help to reduce the storage of a certain kind of fat on the body…
- Trial name
- NCT02375113
- Testing
- soy supplementation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas at San Antonio
HIV Infections
FEM-PrEP (Truvada®): Study to Assess the Role of Truvada® in Preventing HIV Acquisition in Women
This Phase III, double-blind, randomized, placebo-controlled trial enrolled HIV-negative women from 4 sites in 3 countries (Kenya, Tanzania, South Africa).
- Trial name
- NCT00625404
- Testing
- Truvada
- Where
- 4 sites in Kenya, South Africa and 1 more
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- FHI 360
Smoking Cessation
Motivating Change in Aging Smokers
The purpose of this research is to evaluate messages that motivate older smokers to make quit attempts using evidence based smoking treatments (EBSTs).
- Trial name
- NCT05194917
- Testing
- Older Smoker Motivational Intervention, Control Motivational Message
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison