Clinical trials: Prone Position
Skin-to-skin, Preterm Birth
Comparison of Two Different Skin-to-skin Contact Techniques: Sustained Diagonal Flexion vs. Traditional
This is a prospective, controlled randomized study designed to compare the effects of two methods of skin-to-skin positioning of preterm infants: the prone positioning method currently used (according to the World Health…
- Trial name
- NCT06154148
- Testing
- Sustained Diagonal Flexion positioning, Traditional prone position
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Healthy
A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers
Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure.
- Trial name
- NCT05512585
- Testing
- awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Venous Hemodynamics
Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score
The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting.
- Trial name
- VeNIVPro (NCT07273617)
- Testing
- application of PEEP: starting PEEP = 15 mbar, application of PEEP: starting PEEP = 0 mbar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Thoracic Surgical Procedures, One-lung Ventilation (OLV)
Study of Cardiac Power Index During Supine, Lateral, and Between Left and Right Positions During Two- and One-Lung Ventilation (OLV): Comparison of Hemodynamic Changes After Lung Recruitment Maneuver and Fluid Challenge Among Responders and Non-Responders (SVI, MAP, CPI Changes).
The aim of this trial is to study the changes of the Cardiac Power Index (CPI) during supine and lateral decubitus position in two and one lung ventilation respectively.
- Conditions
- Thoracic Surgical Procedures, One-lung Ventilation (OLV), Hemodynamic Changes
- Trial name
- NCT07037225
- Testing
- Fluid challenge during one-lung ventilation (OLV) in the lateral decubitus position, Hemodynamic monitoring
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maria Fountoulaki
Intensive Care Unit Syndrome
The Effect of Prone Position Use Ventilator-Associated Pneumonia in Intensive Care Patients
The aim of this experimental study was to investigate the effect of prone position use on ventilator values, blood gas and ventilator-associated pneumonia in intensive care unit patients.
- Trial name
- prone (NCT05760716)
- Testing
- practicing prone position
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Acne-prone Skin, Skin Disease
Observational Assessment of Skin Appearance Changes During PRX S Cosmetic Treatment in Participants With Acne-Prone Skin
This pilot cohort study evaluates changes in skin surface appearance in adult participants with acne-prone skin during and following a standardized five-session course of PRX S (WiQo SpA), a topical cosmetic product designed for…
- Trial name
- NCT07866131
- Testing
- PRX S topical cosmetic treatment, WiQo home care regimen (Nourishing Cream; Balancing Cream)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- WiQo S.p.A.
Pressure Ulcer
Pressures During Prone Positions in Healthy Volunteers
Prone positioning (PP) reduces mortality in the most severe cases of acute respiratory distress syndrome (ARDS). Despite the benefits of PP, this technique presents adverse effects such as an increased risk of bedsores, linked to…
- Trial name
- HEALTHY-PRONE (NCT06025370)
- Testing
- Prone Position
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Ketosis Prone Diabetes, Diabetic Ketoacidosis
Ketosis Prone Diabetes in African-Americans
Over 50% of obese African-Americans (AA) presenting with newly diagnosed, severe hyperglycemia and/or unprovoked diabetic ketoacidosis (DKA) display clinical, metabolic, and immunogenetic features of type 2 diabetes.
- Conditions
- Ketosis Prone Diabetes, Diabetic Ketoacidosis, Severe Hyperglycemia
- Trial name
- NCT00426413
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Emory University
Skin Microboime, Acne
Study of Skin Balancing Gel Cream Safety and Influence of Skin Microbiome on Acne Prone Skin
The purpose of this study is to assess the safety of the skin balancing gel cream and examine the effects it has on the skin microbiome of individuals with non-cystic acne prone skin.
- Trial name
- NCT05941065
- Testing
- Balancing gel cream
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Pneumonia, Covid19
Prone Position to Improve Oxygenation in COVID-19 Patients Outside Critical Care
Prone positioning is known to improve the PaO2/FiO2 ratio and reduce mortality in patients with ARDS managed in the critical care setting.
- Trial name
- PRONE-COVID (NCT04589936)
- Testing
- Prone positioning
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Infratentorial Neoplasms
Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery
The sitting or prone positions are used for posterior fossa surgery. Although the sitting position may cause hemodynamic instability, venous air embolism, it also provides optimum access to midline lesions, decreases intracranial…
- Trial name
- NCT02933749
- Testing
- SctO2, BIS
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Cosmetic Acne
Effect of a Facial Cream Containing Cannabidiol and Hemp Oil on Skin Hydration and Acne-prone Skin
This research seeks to evaluate the short (i.e., after single application) and long-term (i.e., after periodic application) hydrating effect of a topical preparation containing CBD and hemp oil on facial skin as well as the…
- Trial name
- Dahlia (NCT04045119)
- Testing
- Topical Moisturizer
- Where
- Colombia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Avicanna Inc
Breast Cancer, Radiation Dermatitis
Efficacy Study With StrataXRT for the Prophylaxis of Radiation Dermatitis in Adjuvant Breast Radiation Treatment in Large Breasted Women Using a Prone Technique
For breast cancer patients undergoing adjuvant radiotherapy, radiation dermatitis (RD) is a common occurrence that can negatively impact patients' quality of life (QOL).
- Trial name
- NCT06865131
- Testing
- StrataXRT
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Atopic Dermatitis / Eczema
To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin
The investigation will evaluate, under dermatological control, the cutaneous in-use tolerance of E45 Eczema Repair Emollient with two or three times daily application, over a period of two weeks on children and babies with…
- Trial name
- NCT02857062
- Testing
- E45 Eczema Repair Emollient
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Melanoma, Dysplastic Nevi
Family Study of Melanoma in Italy
During the course of a case-control study of melanoma conducted at the Bufalini Hospital, Cesena, Italy in the years 1994-1996, 20 families with 2 or 3 melanoma cases were identified and studied.
- Conditions
- Melanoma, Dysplastic Nevi, Melanocytic Nevi
- Trial name
- NCT00339222
- Where
- 7 sites in Italy, Spain
- Volunteers
- 1,708 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Anesthesia
Low Fresh Gas Flow in Prone Position
Low flow anesthesia in the prone position was safe in terms of systemic hemodynamics and did not reduce cerebral oxygenation compared to normal flow.
- Trial name
- NCT05462327
- Testing
- Low Fresh Gas Flow in Prone Position, Normal Fresh Gas Flow in Prone Position
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Airway Obstruction
Safety and Efficacy of the LMA Supreme When Inserted With Patients in the Prone Position
This study is a non-randomized, observational, non-comparative prospective study to evaluate the safety, efficacy and performance of the LMA Supreme laryngeal mask airway when used according to the device's Instructions for Use.
- Trial name
- LMA (NCT03633942)
- Testing
- LMA Supreme
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Laser Spine Institute
Atopic Dermatitis, Eczema-Prone Skin
Skin Efficacy and Tolerability of a Cosmetic Product Combination Over 3 Months in Subjects With Atopic Eczema
The aim of this exploratory study is to investigate the short- and long-term efficacy and tolerability of a cosmetic product combination consisting of a body lotion and an intensive care product in subjects with atopic eczema…
- Trial name
- AtoCare-OS (NCT05790083)
- Testing
- Body Lotion and Intensive Care
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bionorica SE
Hypertension, Disk Herniation
Effect of Hypertension on Hemodynamics in the Prone Position
Long-term use of antihypertensive drugs in patients diagnosed with hypertension may cause sharp fluctuations in the patient's hemodynamic values such as blood pressure during anesthesia.
- Trial name
- NCT06649487
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University