Clinical trials: Prolapse, Vaginal
Prolapse; Female
Barbed-suture Efficiency Study for Sacrocolpopexy
Minimally invasive sacrocolpopexy (SCP) performed laparoscopically or with robotic assistance is associated with improved patient-centered outcomes such as faster recovery times, less pain, less bleeding, and shorter hospital…
- Trial name
- BEST (NCT05760794)
- Testing
- Non-barbed delayed absorbable suture, Barbed delayed absorbable suture
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Wake Forest University Health Sciences
Prolapse, Vaginal
Vaginal Native Tissues Repair for Pelvic Organ Prolapse
The aim of the study is to assess at one year the effectiveness of the vaginal patch plastron in comparison of the anterior colporraphy through a combined definition of success: anatomic and functional.
- Trial name
- TAPP (NCT03875989)
- Testing
- Anterior colporraphy, vaginal patch plastron
- Where
- 9 sites in France
- Volunteers
- 214 people
- Sponsor
- University Hospital, Limoges
Anterior Vaginal Wall Prolapse With/Without Apical/Uterine Descent
Multicenter, Prospective, Non-randomized, Single-arm, Interventional Study for the Evaluation of the Safety and Preformance of the SRS Device for the Treatment of Pelvic Organ Prolapse
A prospective, single arm, multi-center clinical study to evaluate the safety and performance of the SRS (Lyra Medical) vaginal mesh in POP patients
- Trial name
- NCT03195361
- Testing
- SRS - Self Retaining Support system
- Where
- 3 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Lyra Medical Ltd.
Vaginal Prolapse
Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse
Pelvic organ prolapse is characterized by a lack of pelvic floor support causing the pelvic organs and vaginal walls to protrude.
- Trial name
- NCT00566917
- Testing
- Anterior colporrhaphy, Anterior PROLIFT
- Where
- 53 sites in Denmark, Finland and 2 more
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Pelvic Organ Prolapse
Feasibility Study of the Reia Vaginal Pessary
The purpose of this study is to obtain preliminary data on the effectiveness, safety, function, comfort, and patient satisfaction with a novel vaginal pessary design for the use in women who suffer from symptoms of pelvic organ…
- Trial name
- NCT04508335
- Testing
- Reia Vaginal Pessary
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Reia, LLC
Same Day Discharge, Pelvic Organ Prolapse
Same Day Discharge Following Pelvic Reconstructive Surgery
This is a prospective cross-sectional study in which patients undergoing major pelvic reconstructive surgery with total vaginal hysterectomy will be recruited and enrolled.
- Conditions
- Same Day Discharge, Pelvic Organ Prolapse, Total Vaginal Hysterectomy
- Trial name
- NCT04804826
- Testing
- Pelvic Reconstructive Surgery
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- TriHealth Inc.
Pelvic Organ Prolapse, Inflammatory Response
Vaginal Probiotics and Pessaries and Their Impact on the Vaginal Microenvironment
In this study, the investigators are evaluating the effect of vaginal probiotics on the bothersome side effects of pessary use and the impact on the vaginal microenvironment (lactobacilli, anaerobic bacteria, mobiluncus bacteria…
- Conditions
- Pelvic Organ Prolapse, Inflammatory Response, Dysbiosis
- Trial name
- NCT04118049
- Testing
- BiopHreshTM vaginal probiotic supplement (Good Clean Love, Inc. Eugene, OR) and RestoreTM gel., Standard Care
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Hartford Hospital
Vaginal Vault Prolapse, Enterocele
Sacrocolpopexy Versus Vaginal Mesh Procedure for Pelvic Prolapse
Pelvic prolapse is one of the most frequent pathology in Gynecology. Recurrency of the prolapse after primary surgery is relatively high, 15-30%.
- Conditions
- Vaginal Vault Prolapse, Enterocele, Uterine Prolapse, Cystocele
- Trial name
- NCT01097200
- Testing
- Elevate mesh, Sacrocolpopexy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Francisco Carmona
Pelvic Organ Prolapse
Evaluation of the Avaulta Procedure for the Correction of Pelvic Organ Prolapse - Results at 1 Year
This study is a 1 year review of all patients who had surgery to correct pelvic organ prolapse (i.e. cystocele, rectocele, enterocele) using the Avaulta synthetic mesh kit.
- Trial name
- NCT00774215
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Atlantic Health System
Colon Cleansing
Will Cleaning the Bowel With an Enema Before Vaginal Prolapse Surgery Prevent Complications?
Traditionally, many gynecologic surgeons have asked patients to perform a cleansing enema the night before a vaginal surgery done to repair pelvic organ prolapse (dropped bladder, dropped uterus).
- Trial name
- NCT00981539
- Testing
- enema
- Where
- 2 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Illinois Urogynecology, Ltd.
Pelvic Organ Prolapse, Prolapse
PDS Versus Prolene as Suture Material for Vaginal Sacrospinous Hysteropexy
Introduction: Pelvic organ prolapse is a common gynecological disease, which about 50% of women develop in the course of their lives. There are many different options for surgical care, e.g.
- Trial name
- NCT05964881
- Testing
- sacrospinous hysteropexy
- Where
- Austria
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
Urinary Continence After Vaginal Surgery for Genital Prolapse in the Spanish Population.
Surgical correction of pelvic organ prolapse (POP) may be associated with the development of postoperative stress urinary incontinence (SUI).
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Urinary Incontinence (UI)
- Trial name
- NCT07628036
- Testing
- Vaginal surgery for pelvic organ prolapse
- Where
- 4 sites in Spain
- Volunteers
- 1,042 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Uterine Prolapse, Vault Prolapse, Vaginal
Pectopexy Autologous Vs Mesh
prospective comparative study describing using autologous graft for uterine- vault - cervical suspension vs mesh in treatment of apical prolapse
- Trial name
- NCT06524700
- Testing
- pectopexy mesh, pectopexy autologous
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- Ain Shams Maternity Hospital
Uterovaginal Prolapse
Study of Uterine Prolapse Procedures - Randomized Trial
The primary purpose of this randomized clinical trial is to compare the effectiveness and safety of two transvaginal apical suspension strategies for uterovaginal prolapse: a mesh augmented hysteropexy versus vaginal hysterectomy…
- Trial name
- SUPeR (NCT01802281)
- Testing
- Uterosacral ligament suspension, Uphold® LITE
- Where
- 8 sites in United States
- Volunteers
- 183 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Pelvic Organ Prolapse
Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques
This study aims to compare the surgical outcomes, safety profiles, and patient satisfaction between two minimally invasive techniques for pelvic organ prolapse repair: Vaginal Natural Orifice Transluminal Endoscopic Surgery…
- Trial name
- vnotes (NCT07082023)
- Testing
- V-NOTES Mesh-Free Sacrocolpopexy, Laparoscopic Mesh-Free Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Havva Betül Bacak
Pelvic Organ Prolapse (POP)
Vaginal Estrogen for Improvement of Outcomes Following Pelvic Organ Prolapse Surgery
This open-label randomized control trial will study the use of vaginal estrogen in the first six weeks after pelvic organ prolapse (POP) repair surgery.
- Trial name
- VEPO (NCT07030426)
- Testing
- Vaginal Estrogen - Twice Weekly, Vaginal Estrogen - Daily
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- Sarah Wozney
Pelvic Organ Prolapse
Anterior Prolapse Repair With and Without Graft Augmentation
This is a randomized control trial comparing anterior colporrhaphy with augmentation with dermal allograft (ARCUS) to anterior colporrhaphy with a suture-based repair (native tissue).
- Trial name
- ARCUS (NCT04085952)
- Testing
- dermal graft (ARCUS repliform) for anterior colporrhaphy, suture based anterior colporrhaphy
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Urogenital Prolapse
LAparoscopic Preventive PRErectal Mesh
Urogenital prolapse is a frequent and invalidating pathology in women, involving the anterior vaginal wall and the uterus in most cases. Posterior vaginal wall prolapse is present in only 50% of cases.
- Trial name
- LAPREM (NCT03766048)
- Testing
- Single-Anterior-Mesh, SAM, Double-Mesh, DM
- Where
- 9 sites in France
- Volunteers
- 834 people
- Sponsor
- University Hospital, Lille
Anterior Vaginal Wall Prolapse, Pelvic Organ Prolapse
Transobturator Lateral Suspension in Anterior Colporrhaphy
Anterior colporrhaphy (AC) is commonly used for anterior vaginal wall prolapse, but suffers high recurrence rates. This randomized trial assessed whether adding transobturator lateral suspension (TOLS) to AC decreases objective…
- Trial name
- TLSAC (NCT07144397)
- Testing
- TOLS
- Where
- Slovenia
- Volunteers
- 44 people
- Sponsor
- University Medical Centre Maribor