Clinical trials: Progression
Smoking, COPD
Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population.
- Trial name
- NCT02153684
- Where
- 3 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Progressive Multiple Sclerosis
Multiple Sclerosis Prediction and Monitoring of Progression Study
Multiple sclerosis (MS) is a auto-immune disease that is mostly characterized by acute clinical relapses and/or focal inflammation in the central nervous system (CNS) followed by recovery.
- Trial name
- PREMONITION (NCT05685784)
- Testing
- Bytelfies kit - sensor dot
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Study of Predictive Factors of Progression of Motor Neurone Disease
Amyotrophic lateral sclerosis (ALS) is a complex polymorph and devastating neurodegenerative disease. Although the pathophysiological mechanisms underlying the development of ALS remain to be fully elucidated, there have been…
- Trial name
- PULSE (NCT02360891)
- Testing
- biomarkers (composite analysis)
- Where
- 13 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Alzheimers Disease, Mild Cognitive Impairment
Non-expensive and Widely Available Tests as Diagnostic Tools in Dementia and Their Ability to Predict Disease Progression
Alzheimers disease (AD) is the most common course of cognitive decline and thereby the course of more than half of all cases of dementia.
- Trial name
- DEMPROG (NCT01642420)
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Parkinson Disease
Wearable Assessments in the Clinic and Home in PD
The purpose of this study is to evaluate disease progression in persons with early Parkinson disease, as assessed by digital and electronic sensor data collection to be correlated with typical clinical assessments.
- Trial name
- WATCH-PD (NCT03681015)
- Where
- 17 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Prehypertension, Hypertension
Equity in Prevention and Progression of Hypertension by Addressing Barriers to Nutrition and Physical activitY
The goal of this study is to test an intervention to prevent high blood pressure among rural, Black adults living in Alabama. Black adults in this region have one of the highest rates of high blood pressure in the US.
- Conditions
- Prehypertension, Hypertension, Blood Pressure
- Trial name
- EPIPHANY (NCT05367544)
- Testing
- Health Education, Individual-Level Peer Support, Community-Level Peer Support
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Alveolar Bone Resorption
Guided Bone Regeneration in Alveolar Socket
Following tooth extraction, volumetric changes in the soft and hard tissues of the extraction site are expected to occur with considerable resorption of the alveolar bone in both the vertical and the horizontal dimensions.
- Trial name
- GBR_socket (NCT05577663)
- Testing
- Routine treatment of the extraction socket, Socket seal technique by a free gingival graft, Socket seal technique using a synthetic resorbable membrane
- Where
- Greece
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Myopia
Evaluation of the Efficacy in Decreasing Myopia Progression of the Proposed Ophthalmic Lens Prototypes
Evaluation of the efficacy in decreasing myopia progression of the proposed ophthalmic lens prototypes.
- Trial name
- NCT05250206
- Testing
- Myopia control lens
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Indizen Optical Technologies, S.L.U.
Patient Deterioration, Patient Monitoring
Wireless Assessment of Respiratory and Circulatory Distress - Europe
Hospital patient monitoring in Europe is often intermittent, which can delay detection of clinical deterioration during hospitalization and after discharge.
- Conditions
- Patient Deterioration, Patient Monitoring, Clinical Deterioration
- Trial name
- WARD-EU (NCT07451249)
- Testing
- WARD-CSS (Wireless Assessment of Respiratory and Circulatory Distress - Clinical Support System)
- Where
- 5 sites in Denmark, Netherlands and 2 more
- Volunteers
- 1,240 people, healthy volunteers welcome
- Sponsor
- Eske Kvanner Aasvang
Tooth Wear
Can Surface Roughness Predict Progression of Tooth Wear?
The clinical study was a single-blind, randomised intervention study to measure surface changes of polished and unpolished enamel in situ following an orange juice acid challenge.
- Trial name
- NCT03178968
- Testing
- Orange juice
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College London
Myopia
The Incidence and Progression of Myopia: Cohort Study
A cohort study on incidence and progression of myopia in a group of medical students
- Trial name
- NCT03244670
- Testing
- Observation study only, no specific intervention
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Lens Opacity
Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government.
- Trial name
- NCT01142960
- Testing
- Starch, Lycium Barbarum
- Where
- Hong Kong
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Peri-Implantitis, Bleeding of Subgingival Space
Incidence of Bleeding on Probing as an Indicator of Peri-Implant Disease Progression
The primary goal of the present prospective cohort study is to evaluate the effect of varying incidences of BOP at implant sites across 15 months of maintenance visits on the probability of peri-implant disease progression.
- Trial name
- BOP (NCT06033859)
- Testing
- Clinical measurements, Radiographic measurement, Dental prophylaxis or maintenance
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Elderly, Sedentary
Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly
The aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and…
- Trial name
- FIT (NCT01899586)
- Testing
- Regional Specific Training Stimulus (RSTS), Aerobic Exercise Regimen (AE)
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Duke University
Colorectal Cancer
The Roles of Exosomal Circ-LRBA and 451/CRTC2 Signaling Axis in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Most of the patients with colorectal cancer were diagnosed in poor stage.
- Trial name
- NCT05579353
- Testing
- nothing
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jingbo Chen
HIV Infections, Immune Activation
The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
Background Commencement of lifelong highly active antiretroviral therapy (HAART) immediately after HIV diagnosis (option B+), for treatment of human immunodeficiency virus (HIV), has greatly improved maternal-infant health in sub…
- Conditions
- HIV Infections, Immune Activation, Comorbidities
- Trial name
- UZ-CHS-BC (NCT04087239)
- Testing
- HIV
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Myopia, Myopia, Progressive
Kubota Glass Parameter Refinement Study
Length of the eye will be measured in subjects exposed to various stimulus characteristics using an electronic spectacle which presents illuminated targets to the eye.
- Conditions
- Myopia, Myopia, Progressive, Vision Disorders
- Trial name
- NCT06085430
- Testing
- Kubota Glass
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kubota Vision Inc.
Caries
Effect of CPP-ACP With/Without Fl on White Spot Lesion,Salivary pH and fl Release in High Caries Risk Patients
Effect of CPP-ACP pastes with/without Fluoride on White spot lesion progression, salivary pH and fluoride release in high caries risk Patients, over 3 month period using VistaCam, Digital pH meter and Selective ion electrode.
- Trial name
- NCT03656432
- Testing
- CPP-ACP paste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Myopia, Myopia Progression, Lag of Accommodation, Hyperopic Retinal Blur, Reduction in Contrast
Lag of Accommodation With DOT Spectacle Lenses
The objective of the study is to measure the difference in the lag of accommodation between DOT spectacle lenses and control spectacles.
- Trial name
- ASH (NCT04700111)
- Testing
- DOT Pattern, Control Spectacles
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Multiple Myeloma, Multiple Myeloma Progression
CHAAMP (CHArlotte Advocate MGUS Project) Internal Pilot Study
The purpose of this study is to identify multiple myeloma in the precancerous MGUS stage in order to reduce the risk of delayed diagnosis of multiple myeloma, decrease morbidity related to multiple myeloma at progression, and…
- Conditions
- Multiple Myeloma, Multiple Myeloma Progression, Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM)
- Trial name
- NCT06644625
- Testing
- Blood draw for the laboratory assessment
- Where
- United States
- Volunteers
- 1,665 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences