Clinical trials: Progression, Clinical
Interstitial Pneumonia
The Clinical Course of Interstitial Pneumonia With Autoimmune Features
Interstitial pneumonia with autoimmune features (IPAF) is a chronic interstitial lung disease (ILD) with some laboratoristic and/or clinical features of autoimmune disease, but without meeting criteria of connective tissue…
- Trial name
- NCT03950583
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Myopia
Essilor® Stellest® Lenses Multicentre European Study (SLOMES)
The goal of this post-market clinical follow up Study is to demonstrate the efficacy, safety, acceptability, and quality of life implications of Essilor® Stellest® spectacle lenses in slowing myopia progression in European…
- Trial name
- SLOMES (NCT06263946)
- Testing
- Essilor® Stellest® spectacle lenses
- Where
- 3 sites in France, Ireland and 1 more
- Volunteers
- 150 people
- Sponsor
- Essilor International
Multiple Sclerosis
THE EFFECTS OF AEROBİC EXERCİSE ON NEUROVASCULAR UNİT AND CLİNİCAL PROGRESSİON MARKERS İN INDİVİDUALS WİTH MULTİPLE SCLEROSİS
This study is a randomised controlled trial designed to thoroughly investigate the effects of aerobic exercise on NVU biomarkers in individuals with MS.
- Trial name
- NCT07325019
- Testing
- aerobic exercise intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Lokman Hekim University
Educational Problems
PBP Versus Halsted's Model: the PROVESA Trial
This randomized controlled trial aims to compare the effectiveness of Halsted's apprenticeship approach to training with the PBP approach for teaching the robotic suturing of a VUA on a chicken model.
- Trial name
- PROVESA (NCT04786834)
- Testing
- Vesico urethral anastomosis on chicken model
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Stefano Puliatti
Upper Respiratory Infections
Evaluation of Accuracy and Ease of Use of the FilmArray™ Respiratory Panel (RP EZ) in a CLIA-Waived Clinical Setting
The purpose of this study is to assess the accuracy and ease-of-use of a simplified FilmArray Respiratory Panel test (FilmArray RP EZ) when performed according to the manufacturer's instructions by personnel in laboratories…
- Trial name
- NCT02232711
- Where
- 4 sites in United States
- Volunteers
- 1,082 people
- Sponsor
- BioFire Diagnostics, LLC
Benign Prostatic Hyperplasia
Clinical Progression and Costs in Benign Prostatic Hyperplasia Patients Treated With Early Versus Delayed Combination Therapy
In patients with benign prostatic hyperplasia (BPH), combination therapy with an alpha-blocker (AB) and a 5 alpha-reductase inhibitor (5ARI) has been shown to reduce the progression of acute urinary retention (AUR) and the…
- Trial name
- NCT01435954
- Testing
- Early combination therapy, Delayed combination therapy
- Volunteers
- 13,551 people
- Sponsor
- GlaxoSmithKline
Myopia, Myopia Progression
The Effectiveness and Safety of Two Low-concentration Atropine Sulfate Eye Drops (0.01%/0.02%) for Delaying the Pediatric Myopia Progression
The clinical trial aims to test the effectiveness and safety of two low-dose atropine sulfate eye drops for delaying myopia progression in children and adolescents.
- Trial name
- NCT06708156
- Testing
- Atropine sulfate eye drops 0.01%, Atropine sulfate eye drops 0.02%
- Where
- 25 sites in China
- Volunteers
- 606 people
- Sponsor
- Oupushifang Pharmaceutical Technology Co., Ltd.
Clinical Deterioration
Continuous Wireless Monitoring of Vital Signs and Automated Alerts of Patient Deterioration in Patients Admitted With COVID-19 Infection
For patients admitted with COVID-19 infection, it is often difficult to predict if or when their clinical condition will deteriorate.
- Trial name
- WARD COVID-19 (NCT04724681)
- Testing
- WARD CSS
- Where
- Denmark
- Volunteers
- 97 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Dupuytren's Disease
Repurposing Anti-TNF for Treating Dupuytren's Disease
Dupuytren's disease is a very common condition, affecting 4% of the general UK and US population. It causes the fingers to curl irreversibly into the palm and can be extremely disabling.
- Trial name
- RIDD (NCT03180957)
- Testing
- Adalimumab, Saline
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Oxford
Crohn Disease
Effectiveness of Vedolizumab in CD Patients Naïve to Anti-TNF
Anti-cytokine antibodies, such as Infliximab (an anti TNF alfa chimeric antibody) and Adalimumab (an anti TNF alfa humanize antibody), have been developed and used in clinical practice for the treatment of patients with Crohn…
- Trial name
- NCT02820493
- Testing
- vedolizumab
- Sponsor
- Universita degli Studi di Genova
Overactive Bladder
Overactive Bladder Telemedicine Non-inferiority Trial
In this study, the investigators aim to validate the telemedicine paradigm as a feasible alternative to traditional in-person clinic visits for the management of overactive bladder (OAB).
- Trial name
- OAB Telemed (NCT05117918)
- Testing
- SUFU Clinical Care Pathway for Overactive Bladder, Telemedicine
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prostatic Neoplasms
A Phase I Feasibility Study of an Intraprostatic PSA-Based Vaccine in Men With Prostate Cancer With Local Failure Following Radiotherapy or Cryotherapy or Clinical Progression on Androgen Deprivation Therapy in the Absence of Local Definitive Therapy
Background: Pox viral vectors can induce a PSA-specific T-cell responses and clinical responses in patients with advanced prostate cancer.
- Trial name
- NCT00096551
- Testing
- Recombinant Vaccinia-PSA(L155)/TRICOM (PROSTVAC-V/TRICOM), Recombinant Fowlpox-PSA(L155)/TRICOM (PROSTVAC-F/TRICOM), Recombinant Fowlpox-GM-CSF
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Fingertip Amputation, Finger Injuries
Semi-occlusive Dressing for Pediatric Fingertip Amputations
The aim of this prospective cohort study is to assess the outcome and pain progression of fingertip (partial) amputations treated with a semi-occlusive wound dressing (regular care) in childhood and adolescence.The main questions…
- Trial name
- NCT07552753
- Testing
- semi-occlusive dressings
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Breast Cancer, Lung Metastasis
Concept-verification Clinical Trial on the Inhibition of Breast Cancer Lung Metastasis Progression by Hyperbaric Oxygen
This is a proof-of-concept clinical trial focused on exploring whether hyperbaric oxygen therapy (HBOT) can inhibit the progression of lung metastasis in breast cancer patients.
- Conditions
- Breast Cancer, Lung Metastasis, Hyperbaric Oxygen Therapy
- Trial name
- HBOIBCLM (NCT07514728)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinan Central Hospital
Breast Cancer
A Phase II Study of Trastuzumab Deruxtecan (T-DXd) Plus Pyrotinib in HER2-Positive Advanced Breast Cancer After Progression on T-DXd
This is a single-arm, exploratory, phase II study evaluating the efficacy and safety of trastuzumab deruxtecan (T-DXd) in combination with pyrotinib in patients with HER2-positive advanced breast cancer whose disease has…
- Trial name
- NCT07836257
- Testing
- Trastuzumab Deruxtecan (T-DXd), Pyrotinib
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Fujian Medical University
Slowing the Progression of Myopia in Children
The Safety and Efficacy of HR19034 in Children With Myopia
The study is being conducted to evaluate the efficacy, and safety of HR19034 Eye Drops. To explore the reasonable dosage of HR19034 for slowing the progression of myopia in children
- Trial name
- NCT07844356
- Testing
- HR19034
- Where
- China
- Volunteers
- 509 people
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
SCLC, Limited Stage
A Multicenter, Open-label, Randomized, Prospective Clinical Study of Adebrelimab Consolidation Therapy for Limited-Stage Small-Cell Lung Cancer (LS-SCLC) Without Progression After Concurrent Chemoradiotherapy
This study aims to evaluate the efficacy and safety of adebrelimab consolidation therapy after progression-free response of concurrent chemoradiotherapy in patients with limited-stage small cell lung cancer.
- Trial name
- ARL-LS-SCLC (NCT07559786)
- Testing
- CCRT(Employed residual field irradiation(RFI)), CCRT(Involved-Field Radiotherapy (IFRT))
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Henan Cancer Hospital
End-Stage Renal Disease, Kidney Transplantation
A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney transplants.
- Trial name
- NCT00005113
- Testing
- Cyclosporine, Sirolimus, Tacrolimus
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Boston Children's Hospital
Sarcoma, Biomarkers
The Exploration of OX40 (CD134) Expression Levels in Sarcoma Specimens and Its Clinical Application in Prognosis Determination
This study aims to investigate the expression of OX40 (CD134) in sarcomas and its impact on prognosis, with the goal of identifying novel biomarkers for early resistance detection and optimizing treatment strategies for sarcoma…
- Conditions
- Sarcoma, Biomarkers, Progression
- Trial name
- NCT06751251
- Testing
- IHC: Immunohistochemistry, RNA-seq
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Inflammatory Bowel Disease (IBD), Hepatitis B Virus
Impact of Hepatitis B Virus on Inflammatory Bowel Disease
The goal of this observational retrospective study is to assess the impact of hepatitis B virus (HBV) infection on the clinical course and outcomes of inflammatory bowel disease (IBD) in Egyptian patients.
- Trial name
- NCT06881238
- Testing
- History of IBD course and outcome in HBV patients
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Tanta University