Clinical trials: Prognostic Cancer Model
Leptomeningeal Metastasis in Breast Cancer
Development of a Novel Graded Prognostic Assessment (BC-LGPA) Model for Breast Cancer Leptomeningeal Metastasis
The investigators conducted a large, multicenter retrospective study of patients with breast cancer leptomeningeal metastasis (BCLM), constituting one of the largest and most comprehensively curated cohorts to date.
- Trial name
- NCT07386886
- Testing
- systematic therapy
- Volunteers
- 403 people
- Sponsor
- Jian Zhang,MD
Endometrial Cancer
Radiomics and Radiogenomics Models to Predict Molecular Integrated Risk Classes and Prognostic Factors in Endometrial Cancer.
The aim is to develop radiogenomics models to stratify patients into three main risk categories (Favorable, Intermediate, and Unfavorable) according to the ProMisE model (9) and use these models to predict the most prognostically…
- Trial name
- Romantic (NCT06279832)
- Testing
- trascriptomic profiling
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
HCC - Hepatocellular Carcinoma
Sarcopenia and Systemic Therapy in HCC
This is a multi-center, retrospective observational study in patients with liver cancer (HCC) to assess the impact of sarcopenia (muscle loss) on the prognosis, duration, and tolerance of systemic treatment.
- Trial name
- Sarco HCC (NCT06805552)
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Prognostic Cancer Model, Chemotherapy
Colorectal Cancer Dataset in Xijing Hospital From 2011
To compare the differences of clinical pathological, treatment and prognosis in the guided subgroups in colorectal cancer, the investigator enrolled all the colorectal cancer patients who underwent surgery and were hospitalized…
- Conditions
- Prognostic Cancer Model, Chemotherapy, Nutrition Related Cancer
- Trial name
- NCT06308354
- Where
- China
- Volunteers
- 40,000 people
- Sponsor
- Xijing Hospital
Predictive Cancer Model
Deep Learning Magnetic Resonance Imaging Radiomic Predict Platinum-sensitive in Patients With Epithelial Ovarian Cancer
Platinum-sensitive is an important basis for the treatment of recurrent epithelial ovarian cancer (EOC) without effective methods to predict.We aimed to develop and validate the EOC deep learning system to predict the…
- Trial name
- NCT04511481
- Testing
- Radiomic Algorithm
- Where
- China
- Volunteers
- 93 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer
This trial studies treatment effects on development of chemotherapy-induced peripheral neuropathy in patients with cancer. Treatments for cancer can cause a problem to the nervous system (called peripheral neuropathy) that can…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT03939481
- Testing
- Chemotherapy, Functional Assessment, Questionnaire Administration
- Where
- 169 sites in United States, Chile and 2 more
- Volunteers
- 1,336 people
- Sponsor
- SWOG Cancer Research Network
Hodgkin Lymphoma
Prognostic Model of Elderly Hodgkin Lymphoma in China
This multicenter observational cohort study is based on a patient registry designed to systematically collect uniform real-world clinical data from elderly patients with Hodgkin lymphoma (HL) in China.
- Trial name
- NCT07374068
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colorectal Cancer, Peritoneal Metastases
Development and Validation of a PSN-AI Prediction Model
Heterogeneity concerning survival in synchronous peritoneal metastasis from patients with colorectal cancer exists, thereby further classification is urgently required.
- Trial name
- PSN-AI (NCT06231524)
- Testing
- Analyse pathologic slides
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Hepatocellular Carcinoma (HCC)
HCC-MPDS Multimodal Deep Learning Prognostic Model for Resectable HCC
This is a completed multi-center retrospective observational study focusing on patients who received curative surgical resection for hepatocellular carcinoma (HCC).
- Trial name
- HCC-MPDS (NCT07700082)
- Where
- China
- Volunteers
- 555 people
- Sponsor
- Anhui Provincial Hospital
Nasopharyngeal Cancer
A Study of Nasopharyngeal Carcinoma From Guangdong
This prospective cohort study aims to establish prognostic models, to discover toxicity associated predictors and to validate randomized trials in clinical practice.
- Trial name
- NCT03003182
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-sen University
Metastasis, Predictive Cancer Model
Predicting Tumor Metastasis by Employing a Target Organ/Primary Lesion Fusion Radiomics Model
A pre-metastatic target organ/primary lesion fusion radiomics model was developed based on the "soil-seed" theory to predict comman tumor metastasis in retrospective settings.
- Trial name
- NCT06202404
- Where
- 2 sites in China
- Volunteers
- 166 people
- Sponsor
- Fudan University
Colorectal Cancer, Colorectal Adenoma
COLO-COHORT (Colorectal Cancer Cohort) Study
This is a cross-sectional study aimed at identifying factors which best predicts patients at high risk of colorectal cancer or colorectal adenomas and to develop a risk prediction model.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasm, Predictive Cancer Model
- Trial name
- NCT04185779
- Testing
- Colonoscopy
- Where
- 3 sites in United Kingdom
- Volunteers
- 15,000 people
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
Melanoma
Survival Study for Participants Treated With Ipilimumab-Nivolumab Combination Therapy
This study will review published trial literature and documents for Overall Survival (OS) to evaluate the association between the hazard of death and each baseline variable.
- Trial name
- NCT03438279
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Bristol-Myers Squibb
Ovarian Cancer, Neoadjuvant Chemotherapy
New Prognostic Index for Neoadjuvant Chemotherapy Outcome in Patients With Advanced High-grade Serous Ovarian Cancer
A validated prognostic index for the outcome of advanced high-grade serous ovarian cancer (HGSOC) patients undergoing neoadjuvant chemotherapy (NACT) is still lacking.
- Conditions
- Ovarian Cancer, Neoadjuvant Chemotherapy, Prognostic Cancer Model
- Trial name
- NCT06120309
- Testing
- CRS scoring, Routine blood laboratory testing before treatment
- Where
- China
- Volunteers
- 465 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Predictive Cancer Model, Lung Cancer
CT-based Radiomic Algorithm for Assisting Surgery Decision and Predicting Immunotherapy Response of NSCLC
The purpose of this study was to investigate whether the combined radiomic model based on radiomic features extracted from focus and perifocal area (5mm) can effectively improve prediction performance of distinguishing…
- Conditions
- Predictive Cancer Model, Lung Cancer, Preinvasive Adenocarcinoma
- Trial name
- TOP-RLC (NCT04452058)
- Testing
- Radiomic Algorithm
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hepatocellular Carcinoma
Comprehensive Prognostic Model: The Study Introduces a Novel Prognostic Model That Incorporates a Wide Range of Clinical and Laboratory Variables, Providing a More Holistic Approach to Predicting Overall Survival in HCC Patients
Background: Hepatocellular carcinoma (HCC) is a significant health problem in China, with high incidence and mortality rates. This study aimed to identify the prognostic factors of elderly HCC patients in southwest China and…
- Trial name
- NCT06550739
- Testing
- Randomization
- Where
- China
- Volunteers
- 1,053 people
- Sponsor
- Haike Lei
Predictive Cancer Model, Localized Prostate Carcinoma
Generation and Validation of Predictive Models for Localized Prostate Cancer Treated With External Radiotherapy.
The generation of predictive models in radiotherapy has seen a significant increase. In 2017, Raymond published the largest systematic review of predictive prognostic models for biochemical relapse (BR), metastasis-free survival…
- Trial name
- NCT06092918
- Testing
- EXTERNAL RADIOTHERAPY
- Volunteers
- 700 people
- Sponsor
- Consorci Sanitari de Terrassa
IBD (Inflammatory Bowel Disease), Colon Cancer
Microbiota: Its Role in Chronic Inflammation, IDB and Risk of Colorectal Cancer. Evaluation of a Predictive Prognostic Model With Therapeutic Implications
The gut microbiome is emerging as a crucial factor in several intestinal diseases, contributing to the etiopathogenesis of inflammatory disorders.
- Trial name
- NCT07106463
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Messina
Prostate Cancer
Expression of Tumor Markers in Circulating Tumor Cells of Metastatic Hormone-sensitive Prostate Cancer
As prostate cancer progresses, tumor cells dissociate and enter the bloodstream. Considered a "liquid biopsy," these circulating tumor cells (CTC) can show how a patient's cancer evolves and responds to treatments.
- Trial name
- NCT02723526
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Hepatocellular Carcinoma
Prognostic Models for HCC Based on Tumor Micronecrosis
The heterogeneity of hepatocellular carcinoma (HCC) leads to the unsatisfying predicting performance of current staging systems. HCC patients with pathological tumor micronecrosis have immunosuppressive microenvironment.
- Trial name
- NCT05837065
- Testing
- observing whether HCC patients having tumor micronecrosis
- Where
- China
- Volunteers
- 765 people
- Sponsor
- Zhejiang University